Yeast AP-1 like transcription factors (Yap) and stress response: A current overview

Claudina Rodrigues-Pousada, Frédéric Devaux, Soraia M. Caetano, Catarina Pimentel, Sofia da Silva, Ana Carolina Cordeiro, Catarina Amaral

Research output: Contribution to journalReview articlepeer-review

57 Citations (Scopus)
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Yeast adaptation to stress has been extensively studied. It involves large reprogramming of genome expression operated by many, more or less specific, transcription factors. Here, we review our current knowledge on the function of the eight Yap transcription factors (Yap1 to Yap8) in Saccharomyces cerevisiae, which were shown to be involved in various stress responses. More precisely, Yap1 is activated under oxidative stress, Yap2/Cad1 under cadmium, Yap4/Cin5 and Yap6 under osmotic shock, Yap5 under iron overload and Yap8/Arr1 by arsenic compounds. Yap3 and Yap7 seem to be involved in hydroquinone and nitrosative stresses, respectively. The data presented in this article illustrate how much knowledge on the function of these Yap transcription factors is advanced. The evolution of the Yap family and its roles in various pathogenic and non-pathogenic fungal species is discussed in the last section.

Original languageEnglish
Pages (from-to)267-285
Number of pages19
JournalMicrobial Cell
Issue number6
Publication statusPublished - 1 Jun 2019


  • BZIP
  • Cis-elements
  • Stress
  • Yap factors
  • Yeast


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