Yeast and other lower eukaryotic organisms for studies of Vps13 proteins in health and disease

Weronika Rzepnikowska, Krzysztof Flis, Sandra Muñoz-Braceras, Regina Menezes, Ricardo Escalante, Teresa Zoladek

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Human Vps13 proteins are associated with several diseases, including the neurodegenerative disorder Chorea-acanthocytosis (ChAc), yet the biology of these proteins is still poorly understood. Studies in Saccharomyces cerevisiae, Dictyostelium discoideum, Tetrahymena thermophila and Drosophila melanogaster point to the involvement of Vps13 in cytoskeleton organization, vesicular trafficking, autophagy, phagocytosis, endocytosis, proteostasis, sporulation and mitochondrial functioning. Recent findings show that yeast Vps13 binds to phosphatidylinositol lipids via 4 different regions and functions at membrane contact sites, enlarging the list of Vps13 functions. This review describes the great potential of simple eukaryotes to decipher disease mechanisms in higher organisms and highlights novel insights into the pathological role of Vps13 towards ChAc.

Original languageEnglish
Pages (from-to)711-719
Number of pages9
JournalTraffic
Volume18
Issue number11
DOIs
Publication statusPublished - 1 Nov 2017

Keywords

  • budding yeast
  • Chorea-acanthocytosis (ChAc)
  • chorein
  • Cohen syndrome
  • Dictyostelium discoideum
  • model organisms
  • Saccharomyces cerevisiae
  • tipC
  • VPS13 (YLL040C)
  • Vps13 proteins

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    Rzepnikowska, W., Flis, K., Muñoz-Braceras, S., Menezes, R., Escalante, R., & Zoladek, T. (2017). Yeast and other lower eukaryotic organisms for studies of Vps13 proteins in health and disease. Traffic, 18(11), 711-719. https://doi.org/10.1111/tra.12523