Work participation in spondyloarthritis across countries

analysis from the ASAS-COMOSPA study

Santiago Rodrigues Manica, Alexandre Sepriano, Sofia Ramiro, Fernando Pimentel Santos, Polina Putrik, Elena Nikiphorou, Sam Norton, Anna Molto, Maxime Dougados, Désirée van der Heijde, Robert B M Landewé, Filip E van den Bosch, Annelies Boonen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

OBJECTIVES: To explore the role of individual and country level socioeconomic (SE) factors on employment, absenteeism and presenteeism in patients with spondyloarthritis (SpA) across 22 countries worldwide.

METHODS: Patients with a clinical diagnosis of SpA fulfilling the ASAS classification criteria and in working age (≤65 years) from COMOSPA were included. Outcomes of interest were employment status, absenteeism and presenteeism, assessed by the Work Productivity and Activity Impairment Specific General Health questionnaire. Three multivariable models were built (one per outcome) using mixed-effects binomial (for work status) or ordinal regressions (for absenteeism and presenteeism), with country as random effect. The contribution of SE factors at the individual-level (eg, gender, education, marital status) and country-level (healthcare expenditure (HCE) per capita, Human Development Index (HDI) and gross domestic product per capita) SE factors, independent of clinical factors, was assessed.

RESULTS: In total, 3114 patients with SpA were included of which 1943 (62%) were employed. Physical function and comorbidities were related to all work outcomes in expected directions and disease activity also with absenteeism and presenteeism. Higher education (OR 4.2 (95% CI 3.1 to 5.6)) or living in a country with higher HCE (OR 2.3 (1.5 to 3.6)) or HDI (OR 1.9 (1.2 to 3.3)) was positively associated with being employed. Higher disease activity was associated with higher odds for absenteeism (OR 1.5 (1.3 to 1.7)) and presenteeism (OR 2.1 (1.8 to 2.4)). No significant association between individual-level and country-level SE factors and absenteeism or presenteeism was found.

CONCLUSIONS: Higher education level and higher country SE welfare are associated with a higher likelihood of keeping patients with SpA employed. Absenteeism and presenteeism are only associated with clinical but not with individual-level or country-level SE factors.

Original languageEnglish
Pages (from-to)1303-1310
Number of pages8
JournalAnnals of the rheumatic diseases
Volume77
Issue number9
Early online date2 Jun 2018
DOIs
Publication statusPublished - 1 Sep 2018

Fingerprint

Absenteeism
Education
Human Development
Health Expenditures
Productivity
Health
Gross Domestic Product
Delivery of Health Care
Marital Status
Presenteeism
Comorbidity
Efficiency

Keywords

  • economic evaluations
  • epidemiology
  • outcomes research
  • spondyloarthritis

Cite this

Rodrigues Manica, Santiago ; Sepriano, Alexandre ; Ramiro, Sofia ; Pimentel Santos, Fernando ; Putrik, Polina ; Nikiphorou, Elena ; Norton, Sam ; Molto, Anna ; Dougados, Maxime ; van der Heijde, Désirée ; Landewé, Robert B M ; van den Bosch, Filip E ; Boonen, Annelies. / Work participation in spondyloarthritis across countries : analysis from the ASAS-COMOSPA study. In: Annals of the rheumatic diseases. 2018 ; Vol. 77, No. 9. pp. 1303-1310.
@article{dc179d952fcf423da50a24f16ec265d3,
title = "Work participation in spondyloarthritis across countries: analysis from the ASAS-COMOSPA study",
abstract = "OBJECTIVES: To explore the role of individual and country level socioeconomic (SE) factors on employment, absenteeism and presenteeism in patients with spondyloarthritis (SpA) across 22 countries worldwide.METHODS: Patients with a clinical diagnosis of SpA fulfilling the ASAS classification criteria and in working age (≤65 years) from COMOSPA were included. Outcomes of interest were employment status, absenteeism and presenteeism, assessed by the Work Productivity and Activity Impairment Specific General Health questionnaire. Three multivariable models were built (one per outcome) using mixed-effects binomial (for work status) or ordinal regressions (for absenteeism and presenteeism), with country as random effect. The contribution of SE factors at the individual-level (eg, gender, education, marital status) and country-level (healthcare expenditure (HCE) per capita, Human Development Index (HDI) and gross domestic product per capita) SE factors, independent of clinical factors, was assessed.RESULTS: In total, 3114 patients with SpA were included of which 1943 (62{\%}) were employed. Physical function and comorbidities were related to all work outcomes in expected directions and disease activity also with absenteeism and presenteeism. Higher education (OR 4.2 (95{\%} CI 3.1 to 5.6)) or living in a country with higher HCE (OR 2.3 (1.5 to 3.6)) or HDI (OR 1.9 (1.2 to 3.3)) was positively associated with being employed. Higher disease activity was associated with higher odds for absenteeism (OR 1.5 (1.3 to 1.7)) and presenteeism (OR 2.1 (1.8 to 2.4)). No significant association between individual-level and country-level SE factors and absenteeism or presenteeism was found.CONCLUSIONS: Higher education level and higher country SE welfare are associated with a higher likelihood of keeping patients with SpA employed. Absenteeism and presenteeism are only associated with clinical but not with individual-level or country-level SE factors.",
keywords = "economic evaluations, epidemiology, outcomes research, spondyloarthritis",
author = "{Rodrigues Manica}, Santiago and Alexandre Sepriano and Sofia Ramiro and {Pimentel Santos}, Fernando and Polina Putrik and Elena Nikiphorou and Sam Norton and Anna Molto and Maxime Dougados and {van der Heijde}, D{\'e}sir{\'e}e and Landew{\'e}, {Robert B M} and {van den Bosch}, {Filip E} and Annelies Boonen",
note = "{\circledC} Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.",
year = "2018",
month = "9",
day = "1",
doi = "10.1136/annrheumdis-2018-213464",
language = "English",
volume = "77",
pages = "1303--1310",
journal = "Annals of the rheumatic diseases",
issn = "0003-4967",
publisher = "BMJ Publishing Group: BMJ",
number = "9",

}

Rodrigues Manica, S, Sepriano, A, Ramiro, S, Pimentel Santos, F, Putrik, P, Nikiphorou, E, Norton, S, Molto, A, Dougados, M, van der Heijde, D, Landewé, RBM, van den Bosch, FE & Boonen, A 2018, 'Work participation in spondyloarthritis across countries: analysis from the ASAS-COMOSPA study', Annals of the rheumatic diseases, vol. 77, no. 9, pp. 1303-1310. https://doi.org/10.1136/annrheumdis-2018-213464

Work participation in spondyloarthritis across countries : analysis from the ASAS-COMOSPA study. / Rodrigues Manica, Santiago; Sepriano, Alexandre; Ramiro, Sofia; Pimentel Santos, Fernando; Putrik, Polina; Nikiphorou, Elena; Norton, Sam; Molto, Anna; Dougados, Maxime; van der Heijde, Désirée; Landewé, Robert B M; van den Bosch, Filip E; Boonen, Annelies.

In: Annals of the rheumatic diseases, Vol. 77, No. 9, 01.09.2018, p. 1303-1310.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Work participation in spondyloarthritis across countries

T2 - analysis from the ASAS-COMOSPA study

AU - Rodrigues Manica, Santiago

AU - Sepriano, Alexandre

AU - Ramiro, Sofia

AU - Pimentel Santos, Fernando

AU - Putrik, Polina

AU - Nikiphorou, Elena

AU - Norton, Sam

AU - Molto, Anna

AU - Dougados, Maxime

AU - van der Heijde, Désirée

AU - Landewé, Robert B M

AU - van den Bosch, Filip E

AU - Boonen, Annelies

N1 - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - OBJECTIVES: To explore the role of individual and country level socioeconomic (SE) factors on employment, absenteeism and presenteeism in patients with spondyloarthritis (SpA) across 22 countries worldwide.METHODS: Patients with a clinical diagnosis of SpA fulfilling the ASAS classification criteria and in working age (≤65 years) from COMOSPA were included. Outcomes of interest were employment status, absenteeism and presenteeism, assessed by the Work Productivity and Activity Impairment Specific General Health questionnaire. Three multivariable models were built (one per outcome) using mixed-effects binomial (for work status) or ordinal regressions (for absenteeism and presenteeism), with country as random effect. The contribution of SE factors at the individual-level (eg, gender, education, marital status) and country-level (healthcare expenditure (HCE) per capita, Human Development Index (HDI) and gross domestic product per capita) SE factors, independent of clinical factors, was assessed.RESULTS: In total, 3114 patients with SpA were included of which 1943 (62%) were employed. Physical function and comorbidities were related to all work outcomes in expected directions and disease activity also with absenteeism and presenteeism. Higher education (OR 4.2 (95% CI 3.1 to 5.6)) or living in a country with higher HCE (OR 2.3 (1.5 to 3.6)) or HDI (OR 1.9 (1.2 to 3.3)) was positively associated with being employed. Higher disease activity was associated with higher odds for absenteeism (OR 1.5 (1.3 to 1.7)) and presenteeism (OR 2.1 (1.8 to 2.4)). No significant association between individual-level and country-level SE factors and absenteeism or presenteeism was found.CONCLUSIONS: Higher education level and higher country SE welfare are associated with a higher likelihood of keeping patients with SpA employed. Absenteeism and presenteeism are only associated with clinical but not with individual-level or country-level SE factors.

AB - OBJECTIVES: To explore the role of individual and country level socioeconomic (SE) factors on employment, absenteeism and presenteeism in patients with spondyloarthritis (SpA) across 22 countries worldwide.METHODS: Patients with a clinical diagnosis of SpA fulfilling the ASAS classification criteria and in working age (≤65 years) from COMOSPA were included. Outcomes of interest were employment status, absenteeism and presenteeism, assessed by the Work Productivity and Activity Impairment Specific General Health questionnaire. Three multivariable models were built (one per outcome) using mixed-effects binomial (for work status) or ordinal regressions (for absenteeism and presenteeism), with country as random effect. The contribution of SE factors at the individual-level (eg, gender, education, marital status) and country-level (healthcare expenditure (HCE) per capita, Human Development Index (HDI) and gross domestic product per capita) SE factors, independent of clinical factors, was assessed.RESULTS: In total, 3114 patients with SpA were included of which 1943 (62%) were employed. Physical function and comorbidities were related to all work outcomes in expected directions and disease activity also with absenteeism and presenteeism. Higher education (OR 4.2 (95% CI 3.1 to 5.6)) or living in a country with higher HCE (OR 2.3 (1.5 to 3.6)) or HDI (OR 1.9 (1.2 to 3.3)) was positively associated with being employed. Higher disease activity was associated with higher odds for absenteeism (OR 1.5 (1.3 to 1.7)) and presenteeism (OR 2.1 (1.8 to 2.4)). No significant association between individual-level and country-level SE factors and absenteeism or presenteeism was found.CONCLUSIONS: Higher education level and higher country SE welfare are associated with a higher likelihood of keeping patients with SpA employed. Absenteeism and presenteeism are only associated with clinical but not with individual-level or country-level SE factors.

KW - economic evaluations

KW - epidemiology

KW - outcomes research

KW - spondyloarthritis

U2 - 10.1136/annrheumdis-2018-213464

DO - 10.1136/annrheumdis-2018-213464

M3 - Article

VL - 77

SP - 1303

EP - 1310

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

SN - 0003-4967

IS - 9

ER -