Abstract
A new series of water-soluble Ir complexes with N-heterocyclic carbene ligands that bear ester and amide groups has been obtained and fully characterized. The new complexes are highly reactive and selective for the alkylation of amines with alcohols with a 1:1 ratio of reactants in water and in the absence of base or other additives. The catalytic system has a broad substrate scope, which allows the synthesis of a variety of primary and secondary amines in excellent yields. A tolerance to a large range of functional groups was obtained.
| Original language | English |
|---|---|
| Pages (from-to) | 3912-3917 |
| Number of pages | 6 |
| Journal | ChemCatChem |
| Volume | 9 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - 23 Oct 2017 |
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Keywords
- alcohols
- amines
- carbenes
- homogeneous catalysis
- iridium
Cite this
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Water-Soluble Iridium N-Heterocyclic Carbene Complexes for the Alkylation of Amines with Alcohols. / Fernandes, Ana; Royo, Beatriz.
In: ChemCatChem, Vol. 9, No. 20, 23.10.2017, p. 3912-3917.Research output: Contribution to journal › Article
TY - JOUR
T1 - Water-Soluble Iridium N-Heterocyclic Carbene Complexes for the Alkylation of Amines with Alcohols
AU - Fernandes, Ana
AU - Royo, Beatriz
PY - 2017/10/23
Y1 - 2017/10/23
N2 - A new series of water-soluble Ir complexes with N-heterocyclic carbene ligands that bear ester and amide groups has been obtained and fully characterized. The new complexes are highly reactive and selective for the alkylation of amines with alcohols with a 1:1 ratio of reactants in water and in the absence of base or other additives. The catalytic system has a broad substrate scope, which allows the synthesis of a variety of primary and secondary amines in excellent yields. A tolerance to a large range of functional groups was obtained.
AB - A new series of water-soluble Ir complexes with N-heterocyclic carbene ligands that bear ester and amide groups has been obtained and fully characterized. The new complexes are highly reactive and selective for the alkylation of amines with alcohols with a 1:1 ratio of reactants in water and in the absence of base or other additives. The catalytic system has a broad substrate scope, which allows the synthesis of a variety of primary and secondary amines in excellent yields. A tolerance to a large range of functional groups was obtained.
KW - alcohols
KW - amines
KW - carbenes
KW - homogeneous catalysis
KW - iridium
UR - http://www.scopus.com/inward/record.url?scp=85029743353&partnerID=8YFLogxK
U2 - 10.1002/cctc.201700678
DO - 10.1002/cctc.201700678
M3 - Article
VL - 9
SP - 3912
EP - 3917
JO - ChemCatChem
JF - ChemCatChem
SN - 1867-3880
IS - 20
ER -