Water-Soluble Iridium N-Heterocyclic Carbene Complexes for the Alkylation of Amines with Alcohols

Ana Fernandes, Beatriz Royo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A new series of water-soluble Ir complexes with N-heterocyclic carbene ligands that bear ester and amide groups has been obtained and fully characterized. The new complexes are highly reactive and selective for the alkylation of amines with alcohols with a 1:1 ratio of reactants in water and in the absence of base or other additives. The catalytic system has a broad substrate scope, which allows the synthesis of a variety of primary and secondary amines in excellent yields. A tolerance to a large range of functional groups was obtained.

Original languageEnglish
Pages (from-to)3912-3917
Number of pages6
JournalChemCatChem
Volume9
Issue number20
DOIs
Publication statusPublished - 23 Oct 2017

Fingerprint

Iridium
alkylation
Alkylation
carbenes
iridium
Amines
amines
alcohols
Alcohols
Water
bears
Amides
Functional groups
water
amides
esters
Esters
Ligands
ligands
Substrates

Keywords

  • alcohols
  • amines
  • carbenes
  • homogeneous catalysis
  • iridium

Cite this

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abstract = "A new series of water-soluble Ir complexes with N-heterocyclic carbene ligands that bear ester and amide groups has been obtained and fully characterized. The new complexes are highly reactive and selective for the alkylation of amines with alcohols with a 1:1 ratio of reactants in water and in the absence of base or other additives. The catalytic system has a broad substrate scope, which allows the synthesis of a variety of primary and secondary amines in excellent yields. A tolerance to a large range of functional groups was obtained.",
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Water-Soluble Iridium N-Heterocyclic Carbene Complexes for the Alkylation of Amines with Alcohols. / Fernandes, Ana; Royo, Beatriz.

In: ChemCatChem, Vol. 9, No. 20, 23.10.2017, p. 3912-3917.

Research output: Contribution to journalArticle

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AU - Royo, Beatriz

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AB - A new series of water-soluble Ir complexes with N-heterocyclic carbene ligands that bear ester and amide groups has been obtained and fully characterized. The new complexes are highly reactive and selective for the alkylation of amines with alcohols with a 1:1 ratio of reactants in water and in the absence of base or other additives. The catalytic system has a broad substrate scope, which allows the synthesis of a variety of primary and secondary amines in excellent yields. A tolerance to a large range of functional groups was obtained.

KW - alcohols

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KW - carbenes

KW - homogeneous catalysis

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