TY - JOUR
T1 - Water soluble heterometallic potassium-dioxidovanadium(V) complexes as potential antiproliferative agents
AU - Sutradhar, Manas
AU - Fernandes, Maria Alexandra Núncio de Carvalho Ramos
AU - Silva, Joana
AU - Mahmudov, Kamran T.
AU - Guedes da Silva, M. Fatima C.
AU - Pombeiro, Armando J. L.
N1 - Foundation for Science and Technology (FCT) - PTDC/EQU-EQU/122025/2010 ; UID/QUI/00100/2013 ; SFRH/BPD/86067/2012
project Silence is golden (siAu) - PTDC/BBB-NAN/1812/2012;
UID/Multi/04378/2013
PY - 2016/2
Y1 - 2016/2
N2 - Two water soluble heterometallic potassium-dioxidovanadium polymers, [KVO2(L-1)](n) (1) and [KVO2(L-2)(H2O)](n) (2) [H2L1 = (2,3-dihydroxybenzylidene)-2-hydroxybenzohydrazide and H2L2 = (2,3-dihydroxybenzylidene)benzohydrazide], have been synthesized and characterized by IR, NMR, elemental analysis and single crystal X-ray diffraction. The antiproliferative potentials of 1 and 2 were examined towards human colorectal carcinoma (HCT116), and lung (A549) and breast (MCF7) adenocarcinoma cell lines. 1 exhibits a high cytotoxic activity against colorectal carcinoma cells (HCT116), with IC50 lower than those for cisplatin. (C) 2015 Elsevier Inc All rights reserved.
AB - Two water soluble heterometallic potassium-dioxidovanadium polymers, [KVO2(L-1)](n) (1) and [KVO2(L-2)(H2O)](n) (2) [H2L1 = (2,3-dihydroxybenzylidene)-2-hydroxybenzohydrazide and H2L2 = (2,3-dihydroxybenzylidene)benzohydrazide], have been synthesized and characterized by IR, NMR, elemental analysis and single crystal X-ray diffraction. The antiproliferative potentials of 1 and 2 were examined towards human colorectal carcinoma (HCT116), and lung (A549) and breast (MCF7) adenocarcinoma cell lines. 1 exhibits a high cytotoxic activity against colorectal carcinoma cells (HCT116), with IC50 lower than those for cisplatin. (C) 2015 Elsevier Inc All rights reserved.
KW - Dioxidovanadium(V)
KW - Heterometallic complex
KW - X-ray structure
KW - Antiproliferative agent
KW - MONONUCLEAR OXIDOVANADIUM(V) COMPLEX
KW - X-RAY-STRUCTURE
KW - CRYSTAL-STRUCTURE
KW - IN-VITRO
KW - OXOVANADIUM(IV) COMPLEXES
KW - COORDINATION CHEMISTRY
KW - COPPER(II) COMPLEXES
KW - VANADIUM COMPOUNDS
KW - COBALT COMPLEXES
KW - METAL-COMPLEXES
U2 - 10.1016/j.jinorgbio.2015.11.010
DO - 10.1016/j.jinorgbio.2015.11.010
M3 - Article
SN - 0162-0134
VL - 155
SP - 17
EP - 25
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
ER -