Water soluble heterometallic potassium-dioxidovanadium(V) complexes as potential antiproliferative agents

Manas Sutradhar, Maria Alexandra Núncio de Carvalho Ramos Fernandes, Joana Silva, Kamran T. Mahmudov, M. Fatima C. Guedes da Silva, Armando J. L. Pombeiro

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Abstract

Two water soluble heterometallic potassium-dioxidovanadium polymers, [KVO2(L-1)](n) (1) and [KVO2(L-2)(H2O)](n) (2) [H2L1 = (2,3-dihydroxybenzylidene)-2-hydroxybenzohydrazide and H2L2 = (2,3-dihydroxybenzylidene)benzohydrazide], have been synthesized and characterized by IR, NMR, elemental analysis and single crystal X-ray diffraction. The antiproliferative potentials of 1 and 2 were examined towards human colorectal carcinoma (HCT116), and lung (A549) and breast (MCF7) adenocarcinoma cell lines. 1 exhibits a high cytotoxic activity against colorectal carcinoma cells (HCT116), with IC50 lower than those for cisplatin. (C) 2015 Elsevier Inc All rights reserved.

Original languageEnglish
Pages (from-to)17-25
Number of pages9
JournalJournal of Inorganic Biochemistry
Volume155
DOIs
Publication statusPublished - Feb 2016

Keywords

  • Dioxidovanadium(V)
  • Heterometallic complex
  • X-ray structure
  • Antiproliferative agent
  • MONONUCLEAR OXIDOVANADIUM(V) COMPLEX
  • X-RAY-STRUCTURE
  • CRYSTAL-STRUCTURE
  • IN-VITRO
  • OXOVANADIUM(IV) COMPLEXES
  • COORDINATION CHEMISTRY
  • COPPER(II) COMPLEXES
  • VANADIUM COMPOUNDS
  • COBALT COMPLEXES
  • METAL-COMPLEXES

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