Hipersensibilidade à varfarina: que abordagem?

Translated title of the contribution: Warfarin hipersensitivity: how to deal with it?

Ana Furtado Lima, José Reis, Fátima Serrano, Augusta Borges

Research output: Contribution to journalArticlepeer-review

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The authors report a clinical case of warfarin hypersensitivity noticed when a patient, with thromboembolic risk, was submitted to warfarin. She was found to be heterozigotic to -1639G>A (gene VKORC1) and homozygotic to 1075A>C (genotype CYP2C9*3/*3). In this article the warfarin pharmacodinamics and its role over Vitamin K is revisited. It includes some suggested indications for investigating genetic polymorphisms, in order to avoid complications associated with warfarin.
Translated title of the contributionWarfarin hipersensitivity: how to deal with it?
Original languagePortuguese
Pages (from-to)727-30
Number of pages4
JournalActa medica portuguesa
Issue number4
Publication statusPublished - Jul 2010


  • VKORC1


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