Vascular endothelial growth factor and amyotrophic lateral sclerosis

The interplay with exercise and noninvasive ventilation

Rita Carilho, Mamede De Carvalho, Michael Swash, Susana Pinto, Anabela Pinto, Júlia Costa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Introduction: We evaluated plasma vascular endothelial growth factor (VEGF) levels in patients with amyotrophic lateral sclerosis (ALS) with reference to the effects of respiratory failure, noninvasive ventilation (NIV), and exercise. Methods: We studied plasma VEGF levels in 83 ALS patients, 20 healthy controls, and 10 patients with other disorders. There were 4 groups of ALS patients: G1, 27 patients without respiratory problems; G2, 14 patients stabilized on nocturnal NIV; G3, 30 patients presenting with respiratory failure; G4, 12 patients on an aerobic exercise protocol. Results: VEGF plasma levels did not differ significantly between ALS patients and controls, or between ALS groups. In G3, the mean VEGF levels increased 75% during NIV. In G4, the mean VEGF level increased by 300% during the exercise program. VEGF levels did not change during the course of the disease. Conclusions: VEGF levels in ALS depend on changes in ventilation and exercise but are probably not affected by the disease process itself.

Original languageEnglish
Pages (from-to)545-550
Number of pages6
JournalMuscle & Nerve
Volume49
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Noninvasive Ventilation
Amyotrophic Lateral Sclerosis
Vascular Endothelial Growth Factor A
Exercise
Respiratory Insufficiency
Ventilation

Keywords

  • Amyotrophic lateral sclerosis
  • Biomarker
  • Exercise
  • Noninvasive ventilation
  • Plasma VEGF levels

Cite this

Carilho, Rita ; De Carvalho, Mamede ; Swash, Michael ; Pinto, Susana ; Pinto, Anabela ; Costa, Júlia. / Vascular endothelial growth factor and amyotrophic lateral sclerosis : The interplay with exercise and noninvasive ventilation. In: Muscle & Nerve. 2014 ; Vol. 49, No. 4. pp. 545-550.
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abstract = "Introduction: We evaluated plasma vascular endothelial growth factor (VEGF) levels in patients with amyotrophic lateral sclerosis (ALS) with reference to the effects of respiratory failure, noninvasive ventilation (NIV), and exercise. Methods: We studied plasma VEGF levels in 83 ALS patients, 20 healthy controls, and 10 patients with other disorders. There were 4 groups of ALS patients: G1, 27 patients without respiratory problems; G2, 14 patients stabilized on nocturnal NIV; G3, 30 patients presenting with respiratory failure; G4, 12 patients on an aerobic exercise protocol. Results: VEGF plasma levels did not differ significantly between ALS patients and controls, or between ALS groups. In G3, the mean VEGF levels increased 75{\%} during NIV. In G4, the mean VEGF level increased by 300{\%} during the exercise program. VEGF levels did not change during the course of the disease. Conclusions: VEGF levels in ALS depend on changes in ventilation and exercise but are probably not affected by the disease process itself.",
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Vascular endothelial growth factor and amyotrophic lateral sclerosis : The interplay with exercise and noninvasive ventilation. / Carilho, Rita; De Carvalho, Mamede; Swash, Michael; Pinto, Susana; Pinto, Anabela; Costa, Júlia.

In: Muscle & Nerve, Vol. 49, No. 4, 2014, p. 545-550.

Research output: Contribution to journalArticle

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AU - Carilho, Rita

AU - De Carvalho, Mamede

AU - Swash, Michael

AU - Pinto, Susana

AU - Pinto, Anabela

AU - Costa, Júlia

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