Vaginal shedding of hepatitis C virus

R. Gameiro, T. Venneno, E. Prieto, R. Castro, V. Carnall, W. Canas-Ferreira, F. Exposto

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6 Citations (Scopus)

Abstract

A group of 14 women infected with hepatitis C virus (HCV) was evaluated for vaginal shedding of the virus. The HCV-RNA detection was performed in plasma, peripheral blood mononuclear cells (PBMC) and in supernatant and pellet of vaginal washings. HCV-RNA positive results were obtained in all plasma samples, in 57% of the PBMC samples, in 36% pellets obtained following centrifugation of vaginal washings and in 36% of the supernatants. In 21% of the women a positive result was found, at the same time, in every analysed product. The HCV genotypes identified in the plasma samples (1a: 38%; 1b: 36%; 3a: 13% and 1b+3a: 14%) matched with those in PBMC and vaginal washings in every sample, with the exception of cases where mixed infection (1b+3a) was detected. In these, genotype 1b was only detected in plasma. HCV viral load was not associated with the presence of HCV-RNA in PBMC or in vaginal washings (either cells or supernatant).

Original languageEnglish
Pages (from-to)717-721
Number of pages5
JournalInternational Journal of STD and AIDS
Volume12
Issue number11
DOIs
Publication statusPublished - 17 Nov 2001

Keywords

  • Hepatitis C virus
  • PBMC
  • Transmission
  • Vaginal samples
  • Viral load

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    Gameiro, R., Venneno, T., Prieto, E., Castro, R., Carnall, V., Canas-Ferreira, W., & Exposto, F. (2001). Vaginal shedding of hepatitis C virus. International Journal of STD and AIDS, 12(11), 717-721. https://doi.org/10.1258/0956462011924209