Use of organomolybdenum compounds for promoted hydrolysis of phosphoester bonds in aqueous media

Ana C. Gomes, Carla A. Gamelas, José A. Fernandes, Filipe A. Almeida Paz, Patrique Nunes, Martyn Pillinger, Isabel S. Gonçalves, Carlos Jose Romao, Marta Abrantes

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3 Citations (Scopus)

Abstract

The dissolution of the indenyl (Ind) complex [{(η5-Ind) Mo(CO)2(μ-Cl)}2] (1) in N,N'-dimethylformamide (DMF) gives the ring-slipped complex [(η3-Ind)Mo(CO) 2Cl(DMF)2] (2). The aerial oxidation of 2 leads to the formation of the dinuclear oxomolybdenum(V) chloride [Mo2O 2(DMF)4(μ-O)2Cl2] (3). The structures of 2 and 3·DMF have been determined by single-crystal X-ray diffraction. Compounds 1 and 3 were examined as promoters of phosphoester bond hydrolysis in para-nitrophenylphosphate (pNPP), which was used as a model substrate. The reactions were performed in aqueous solution at 55 °C and followed by 1H NMR spectroscopy. For assays performed with 30-100 mol-% of 1 or 3 relative to pNPP, both compounds promote the production of para-nitrophenol (pNPh) from pNPP. Compound 3 is especially active in promoting the hydrolytic cleavage of the phosphoester bond (t1/2 <80 min).

Original languageEnglish
Pages (from-to)3681-3689
Number of pages9
JournalEuropean Journal of Inorganic Chemistry
Issue number23
DOIs
Publication statusPublished - 2014

Keywords

  • Coordination modes
  • Hydrolysis
  • Indenyl ligands
  • Molybdenum
  • Oxido ligands
  • Phosphoesters

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    Gomes, A. C., Gamelas, C. A., Fernandes, J. A., Almeida Paz, F. A., Nunes, P., Pillinger, M., ... Abrantes, M. (2014). Use of organomolybdenum compounds for promoted hydrolysis of phosphoester bonds in aqueous media. European Journal of Inorganic Chemistry, (23), 3681-3689. https://doi.org/10.1002/ejic.201402071