Use of biomarkers in pediatric sepsis: Literature review

Vanessa Soares Lanziotti; Pedro Póvoa; Márcio Soares; José Roberto Lapa E Silva; Arnaldo Prata Barbosa; Jorge Ibrain Figueira Salluh

doi:10.5935/0103-507X.20160080

Use of biomarkers in pediatric sepsis: Literature review

Vanessa Soares Lanziotti, Pedro Póvoa, Márcio Soares, José Roberto Lapa E Silva, Arnaldo Prata Barbosa, Jorge Ibrain Figueira Salluh

NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Research output: Contribution to journal › Review article › peer-review

44 Citations (Scopus)

Abstract

Despite advances in recent years, sepsis is still a leading cause of hospitalization and mortality in infants and children. The presence of biomarkers during the response to an infectious insult makes it possible to use such biomarkers in screening, diagnosis, prognosis (risk stratification), monitoring of therapeutic response, and rational use of antibiotics (for example, the determination of adequate treatment length). Studies of biomarkers in sepsis in children are still relatively scarce. This review addresses the use of biomarkers in sepsis in pediatric patients with emphasis on C-reactive protein, procalcitonin, interleukins 6, 8, and 18, human neutrophil gelatinase, and proadrenomedullin. Assessment of these biomarkers may be useful in the management of pediatric sepsis.

Original language	English
Pages (from-to)	472-482
Number of pages	11
Journal	Revista Brasileira de Terapia Intensiva
Volume	28
Issue number	4
DOIs	https://doi.org/10.5935/0103-507X.20160080
Publication status	Published - 1 Oct 2016

Keywords

Biomakers
Child
Intensive care units
Pediatric
Sepsis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5935/0103-507X.20160080

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AU - Lanziotti, Vanessa Soares

AU - Póvoa, Pedro

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AU - Barbosa, Arnaldo Prata

AU - Salluh, Jorge Ibrain Figueira

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AB - Despite advances in recent years, sepsis is still a leading cause of hospitalization and mortality in infants and children. The presence of biomarkers during the response to an infectious insult makes it possible to use such biomarkers in screening, diagnosis, prognosis (risk stratification), monitoring of therapeutic response, and rational use of antibiotics (for example, the determination of adequate treatment length). Studies of biomarkers in sepsis in children are still relatively scarce. This review addresses the use of biomarkers in sepsis in pediatric patients with emphasis on C-reactive protein, procalcitonin, interleukins 6, 8, and 18, human neutrophil gelatinase, and proadrenomedullin. Assessment of these biomarkers may be useful in the management of pediatric sepsis.

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Use of biomarkers in pediatric sepsis: Literature review

Abstract

Keywords

UN SDGs

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