Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine

Guida Bento; Aygul K Shafigullina; Albert A Rizvanov; Vilma A Sardão; Maria Paula Macedo; Paulo J Oliveira

doi:10.3390/cells9030573

Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine

Guida Bento, Aygul K Shafigullina, Albert A Rizvanov, Vilma A Sardão, Maria Paula Macedo, Paulo J Oliveira

Research output: Contribution to journal › Review article › peer-review

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Abstract

Despite being a biological waste, human urine contains a small population of cells with self-renewal capacity and differentiation potential into several cell types. Being derived from the convoluted tubules of nephron, renal pelvis, ureters, bladder and urethra, urine-derived stem cells (UDSC) have a similar phenotype to mesenchymal stroma cells (MSC) and can be reprogrammed into iPSC (induced pluripotent stem cells). Having simple, safer, low-cost and noninvasive collection procedures, the interest in UDSC has been growing in the last decade. With great potential in regenerative medicine applications, UDSC can also be used as biological models for pharmacology and toxicology tests. This review describes UDSC biological characteristics and differentiation potential and their possible use, including the potential of UDSC-derived iPSC to be used in drug discovery and toxicology, as well as in regenerative medicine. Being a new cellular platform amenable to noninvasive collection for disease stratification and personalized therapy could be a future application for UDSC.

Original language	English
Journal	Cells
Volume	9
Issue number	3
DOIs	https://doi.org/10.3390/cells9030573
Publication status	Published - 28 Feb 2020

Keywords

urine-derived stem cells
personalized medicine
regenerative medicine
induced-pluripotent stem cells
HUMAN UROTHELIAL CELLS
LONG-TERM CULTURE
EPITHELIAL-CELLS
IN-VITRO
DIFFERENTIATION
GENERATION
GROWTH
BLADDER
EXOSOMES

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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cells-09-00573-v2Final published version, 1.22 MB

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@article{55895081187f45a5aeee20860ebc1090,

title = "Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine",

abstract = "Despite being a biological waste, human urine contains a small population of cells with self-renewal capacity and differentiation potential into several cell types. Being derived from the convoluted tubules of nephron, renal pelvis, ureters, bladder and urethra, urine-derived stem cells (UDSC) have a similar phenotype to mesenchymal stroma cells (MSC) and can be reprogrammed into iPSC (induced pluripotent stem cells). Having simple, safer, low-cost and noninvasive collection procedures, the interest in UDSC has been growing in the last decade. With great potential in regenerative medicine applications, UDSC can also be used as biological models for pharmacology and toxicology tests. This review describes UDSC biological characteristics and differentiation potential and their possible use, including the potential of UDSC-derived iPSC to be used in drug discovery and toxicology, as well as in regenerative medicine. Being a new cellular platform amenable to noninvasive collection for disease stratification and personalized therapy could be a future application for UDSC.",

keywords = "urine-derived stem cells, personalized medicine, regenerative medicine, induced-pluripotent stem cells, HUMAN UROTHELIAL CELLS, LONG-TERM CULTURE, EPITHELIAL-CELLS, IN-VITRO, DIFFERENTIATION, GENERATION, GROWTH, BLADDER, EXOSOMES",

author = "Guida Bento and Shafigullina, {Aygul K} and Rizvanov, {Albert A} and Sard{\~a}o, {Vilma A} and Macedo, {Maria Paula} and Oliveira, {Paulo J}",

note = "Work in the laboratories of the authors is funded by FEDER funds through the Operational Programme Competitiveness Factors—COMPETE and national funds by FCT—Foundation for Science and Technology (PTDC/BTM-SAL/29297/2017, POCI-01-0145-FEDER-029297, PTDC/MED-FAR/29391/2017, POCI-01-0145-FEDER-029391, IF/01182/2015 and UIDB/04539/2020). iNOVA4Health-UID/Multi/04462/2013, a program financially supported by Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia/Minist{\'e}rio da Educa{\c c}{\~a}o e Ci{\^e}ncia, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement, is acknowledged. Guida Bento is the recipient of a Ph.D. fellowship from the Foundation for Science and Technology (PD/BD/114119/2015). AKS and AAR were funded by the subsidy allocated to Kazan Federal University for the state assignment in the sphere of scientific activities. Kazan Federal University was supported by the Russian Government Program of Competitive Growth. ",

year = "2020",

month = feb,

day = "28",

doi = "10.3390/cells9030573",

language = "English",

volume = "9",

journal = "Cells",

issn = "2073-4409",

publisher = "MDPI - Multidisciplinary Digital Publishing Institute",

number = "3",

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TY - JOUR

T1 - Urine-Derived Stem Cells

T2 - Applications in Regenerative and Predictive Medicine

AU - Bento, Guida

AU - Shafigullina, Aygul K

AU - Rizvanov, Albert A

AU - Sardão, Vilma A

AU - Macedo, Maria Paula

AU - Oliveira, Paulo J

N1 - Work in the laboratories of the authors is funded by FEDER funds through the Operational Programme Competitiveness Factors—COMPETE and national funds by FCT—Foundation for Science and Technology (PTDC/BTM-SAL/29297/2017, POCI-01-0145-FEDER-029297, PTDC/MED-FAR/29391/2017, POCI-01-0145-FEDER-029391, IF/01182/2015 and UIDB/04539/2020). iNOVA4Health-UID/Multi/04462/2013, a program financially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement, is acknowledged. Guida Bento is the recipient of a Ph.D. fellowship from the Foundation for Science and Technology (PD/BD/114119/2015). AKS and AAR were funded by the subsidy allocated to Kazan Federal University for the state assignment in the sphere of scientific activities. Kazan Federal University was supported by the Russian Government Program of Competitive Growth.

PY - 2020/2/28

Y1 - 2020/2/28

N2 - Despite being a biological waste, human urine contains a small population of cells with self-renewal capacity and differentiation potential into several cell types. Being derived from the convoluted tubules of nephron, renal pelvis, ureters, bladder and urethra, urine-derived stem cells (UDSC) have a similar phenotype to mesenchymal stroma cells (MSC) and can be reprogrammed into iPSC (induced pluripotent stem cells). Having simple, safer, low-cost and noninvasive collection procedures, the interest in UDSC has been growing in the last decade. With great potential in regenerative medicine applications, UDSC can also be used as biological models for pharmacology and toxicology tests. This review describes UDSC biological characteristics and differentiation potential and their possible use, including the potential of UDSC-derived iPSC to be used in drug discovery and toxicology, as well as in regenerative medicine. Being a new cellular platform amenable to noninvasive collection for disease stratification and personalized therapy could be a future application for UDSC.

AB - Despite being a biological waste, human urine contains a small population of cells with self-renewal capacity and differentiation potential into several cell types. Being derived from the convoluted tubules of nephron, renal pelvis, ureters, bladder and urethra, urine-derived stem cells (UDSC) have a similar phenotype to mesenchymal stroma cells (MSC) and can be reprogrammed into iPSC (induced pluripotent stem cells). Having simple, safer, low-cost and noninvasive collection procedures, the interest in UDSC has been growing in the last decade. With great potential in regenerative medicine applications, UDSC can also be used as biological models for pharmacology and toxicology tests. This review describes UDSC biological characteristics and differentiation potential and their possible use, including the potential of UDSC-derived iPSC to be used in drug discovery and toxicology, as well as in regenerative medicine. Being a new cellular platform amenable to noninvasive collection for disease stratification and personalized therapy could be a future application for UDSC.

KW - urine-derived stem cells

KW - personalized medicine

KW - regenerative medicine

KW - induced-pluripotent stem cells

KW - HUMAN UROTHELIAL CELLS

KW - LONG-TERM CULTURE

KW - EPITHELIAL-CELLS

KW - IN-VITRO

KW - DIFFERENTIATION

KW - GENERATION

KW - GROWTH

KW - BLADDER

KW - EXOSOMES

U2 - 10.3390/cells9030573

DO - 10.3390/cells9030573

M3 - Review article

C2 - 32121221

SN - 2073-4409

VL - 9

JO - Cells

JF - Cells

IS - 3

ER -

Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine

Abstract

Keywords

UN SDGs

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