TY - JOUR
T1 - Understanding, assessing and treating immune, endothelial and haemostasis dysfunctions in bacterial sepsis
AU - Girardis, Massimo
AU - David, Sascha
AU - Ferrer, Ricard
AU - Helms, Julie
AU - Juffermans, Nicole P.
AU - Martin-Loeches, Ignacio
AU - Povoa, Pedro
AU - Russell, Lene
AU - Shankar-Hari, Manu
AU - Iba, Toshiaki
AU - Coloretti, Irene
AU - Parchim, Nicholas
AU - Nielsen, Nathan D.
N1 - Funding Information:
SD was supported by the German Research Foundation (DA 1209/7-1), the German Centre for Lung Research (DZL) and the Swiss National Science Foundation (SNSF); MSH was supported by the National Institute for Health Research Clinician Scientist Award (CS-2016-16-011; 2017-2023). MSH reported receiving grants from the Chief Scientist Office Scotland, the National Institute for Health and Care Research (Efficacy and Mechanism Evaluation and Health Technology Assessment programs), The UK Medical Research Council, Canadian Institute for Health Research, and the Huo Foundation. MSH highlights industry support for TRAITS research programme (a Chief Scientists Office, Scotland funded time critical precision medicine in adult critically ill patients (TRAITS Programme) https://traits-trial.ed.ac.uk .
Publisher Copyright:
© Springer-Verlag GmbH Germany, part of Springer Nature 2024.
PY - 2024/10
Y1 - 2024/10
N2 - The interplay between the immune system, coagulation, and endothelium is critical in regulating the host response to infection. However, in sepsis and other critical illnesses, a dysregulated immune response can lead to excessive alterations in these mechanisms, resulting in coagulopathy, endothelial dysfunction, and multi-organ dysfunction. This review aims to provide a comprehensive analysis of the pathophysiological mechanisms that govern the complex interplay between immune dysfunction, endothelial dysfunction, and coagulation in sepsis. It emphasises clinical significance, evaluation methods, and potential therapeutic interventions. Understanding these mechanisms is essential for developing effective treatments that can modulate the immune response, mitigate thrombosis, restore endothelial function, and ultimately improve patient survival.
AB - The interplay between the immune system, coagulation, and endothelium is critical in regulating the host response to infection. However, in sepsis and other critical illnesses, a dysregulated immune response can lead to excessive alterations in these mechanisms, resulting in coagulopathy, endothelial dysfunction, and multi-organ dysfunction. This review aims to provide a comprehensive analysis of the pathophysiological mechanisms that govern the complex interplay between immune dysfunction, endothelial dysfunction, and coagulation in sepsis. It emphasises clinical significance, evaluation methods, and potential therapeutic interventions. Understanding these mechanisms is essential for developing effective treatments that can modulate the immune response, mitigate thrombosis, restore endothelial function, and ultimately improve patient survival.
KW - Coagulation
KW - Endothelium
KW - Immune system
KW - Sepsis
UR - http://www.scopus.com/inward/record.url?scp=85202949817&partnerID=8YFLogxK
U2 - 10.1007/s00134-024-07586-2
DO - 10.1007/s00134-024-07586-2
M3 - Review article
C2 - 39222142
AN - SCOPUS:85202949817
SN - 0342-4642
VL - 50
SP - 1580
EP - 1592
JO - Intensive Care Medicine
JF - Intensive Care Medicine
IS - 10
ER -