Ultrastructural alterations of Mycobacterium leprae in skin biopsies of untreated and treated lepromatous patients

M. T. Silva, P. M. Macedo, M. H.L. Costa, H. Gonçalves, J. Torgal, H. L. David

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Mycobacterium leprae cells under a process of progressive disaggregation are present in the skin of both treated and untreated patients. The ultrastructural alterations observed during the degenerative process seem to be qualitatively similar in treated and untreated patients. The proportion of altered M. leprae cells increases during the treatment, mainly with rifampicin and rifampicin + clofazimine + diaminodiphenyl sulfone. The cell wall of M. leprae is the last bacterial structure to disappear during the degenerative process.

Original languageEnglish
Pages (from-to)75-92
Number of pages18
JournalAnnales de Microbiologie
Volume133 B
Issue number1
Publication statusPublished - 1982

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