TY - JOUR
T1 - Ultrasensitive Colorimetric and Ratiometric Detection of Cu2+
T2 - Acid-Base Properties, Complexation, and Binding Studies
AU - Fanna, Daniel J.
AU - Lima, Luís M.P.
AU - Craze, Alexander R.
AU - Trinchi, Adrian
AU - Wuhrer, Richard
AU - Lindoy, Leonard F.
AU - Wei, Gang
AU - Reynolds, Jason K.
AU - Li, Feng
PY - 2018/9/4
Y1 - 2018/9/4
N2 - Herein, we report the synthesis and characterization of a chemosensor, 5-(diethylamino)-2-(2,3-dihydro-1H-perimidin-2-yl)phenol (HL), synthesized from a condensation between 4-(diethylamino)salicylaldehyde and 1,8-diaminonaphthalene. Upon investigation of the sensing properties of HL, it was found that this sensor may be employed for simple yet efficient detection of Cu2+ in aqueous methanol solutions. The selective and ratiometric response to Cu2+ yielded an outstandingly low limit of detection of 3.7 nM by spectrophotometry and is also useful as a naked-eye sensor from 2.5 μM. The system was studied by spectrophotometric pH titrations to determine Cu2+ binding constants and complex speciation. Binding of Cu2+ to HL occurs in 1:1 stoichiometry, in good agreement with high-resolution electrospray ionization mass spectrometry (ESI-HRMS) results, Cu2+ titrations, and Job's plot experiments, while the coordination geometry was tentatively assigned as square pyramidal by spectroscopic studies.
AB - Herein, we report the synthesis and characterization of a chemosensor, 5-(diethylamino)-2-(2,3-dihydro-1H-perimidin-2-yl)phenol (HL), synthesized from a condensation between 4-(diethylamino)salicylaldehyde and 1,8-diaminonaphthalene. Upon investigation of the sensing properties of HL, it was found that this sensor may be employed for simple yet efficient detection of Cu2+ in aqueous methanol solutions. The selective and ratiometric response to Cu2+ yielded an outstandingly low limit of detection of 3.7 nM by spectrophotometry and is also useful as a naked-eye sensor from 2.5 μM. The system was studied by spectrophotometric pH titrations to determine Cu2+ binding constants and complex speciation. Binding of Cu2+ to HL occurs in 1:1 stoichiometry, in good agreement with high-resolution electrospray ionization mass spectrometry (ESI-HRMS) results, Cu2+ titrations, and Job's plot experiments, while the coordination geometry was tentatively assigned as square pyramidal by spectroscopic studies.
UR - http://www.scopus.com/inward/record.url?scp=85053109102&partnerID=8YFLogxK
U2 - 10.1021/acsomega.8b01483
DO - 10.1021/acsomega.8b01483
M3 - Article
AN - SCOPUS:85053109102
VL - 3
SP - 10471
EP - 10480
JO - ACS Omega
JF - ACS Omega
SN - 2470-1343
IS - 9
ER -