Ulcerative colitis in northern Portugal and Galicia in Spain

Manuel Barreiro-De Acosta, Fernando Magro, Daniel Carpio, Paula Lago, Ana Echarri, José Cotter, Santos Pereira, Raquel Gonçalves, Aurelio Lorenzo, Laura Carvalho, Javier Castro, Luisa Barros, Jorge Amil Dias, Susana Rodrigues, Francisco Portela, Camila Dias, Altamiro Da Costa-Pereira, María Victoria Alvaréz, Pedro Carpintero, Lucía DancausaMaría Luisa De Castro, Alberto Fernández Villaverde, Vicent Hernández, David Martínez Ares, Jesús Martínez Cadilla, Virginia Ollero, José Ignacio Rodríguez Prada, Eva Santos, Ramón Vázquez Dourado, Pablo Vega, Amadeu Corte Real Nunes, Ana Isabel Valente, Ana Isabel Vieira, Antónia Duarte, António Marques, Antonio Queiroz, Bernardino Ribeiro, Carolina Duesca, Celeste Fátima Viveiros, Cidalina Caetano, Claudia Sequeira, David Horta, Edgar Gencsi, Estela Monteiro, Filipe Gomes Silva, Glória Marinho, Helder Cardoso, Helena Vasconcelos, Helena Sousa, Henrique Morna, Horácio Lopes, Isabel Bastos, Isabel Medeiros, Isabel Seves, Isadora Rosa, João Baranda, João Ramos De Deus, J. Godinho Lopes, João Freitas, J. Pinto De Matos, Jorge Reis, Jorge Vieira, José Estevens, J. M. Ribeiro, Leopoldo Matos, Luís Correia, Luís Jasmins, Luis Lebre, Luísa Gloria, Lurdes Tavares, Marília Cravo, Margarida Marques, Marie Isabelle Cremers, Maria Do Rosário Maldonado, Manuel Correia, Maria De Lurdes Gonçalves, Mário César, Miguel Areia, Manuela Ferreira, Mário Júlio Campos, Marta Salgado, Nuno Almeida, Paulo Andrade, Paula Ministro, Paula Moura Santos, Paula Peixe, Paulo Caldeira, Paulo Freire, Pedro Martins, Ricardo Ferreira, Ricardo Freire, Rui Loureiro, Rui Sousa, Rute Cerqueira, Salazar Sousa, Salomé Costa Lima, Sara Folgado Alberto, Silvia Leite, Sofia Mendes, Sónia Barroso, Sandra Lopes, Sónia Nobre, Tiago Bana E Costa, Vítor Fernandes

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Background: Clinical and therapeutic patterns of ulcerative colitis (UC) are variable in different world regions. The purpose of this study was to examine two close independent southern European UC populations from 2 bordering countries and observe how demographic and clinical characteristics of patients can influence the severity of UC. Methods: A cross-sectional study was conducted during a 15-month period (September 2005 to December 2006) based on data of 2 Web registries of UC patients. Patients were stratified according to the Montreal Classification and disease severity was defined by the type of treatment taken. Results: A total of 1549 UC patients were included, 1008 (65%) from northern Portugal and 541 (35%) from Galicia (northwest Spain). A female predominance (57%) was observed in Portuguese patients (P < 0.001). The median age at diagnosis was 35 years and median years of disease was 7. The majority of patients (53%) were treated only with mesalamine, while 15% had taken immunosuppressant drugs, and 3% biologic treatment. Most patients in both groups were not at risk for aggressive therapy. Extensive colitis was a predictive risk factor for immunosuppression in northern Portugal and Galicia (odds ratio [OR] 2.737, 95% confidence interval [CI]: 1.846-4.058; OR 5.799, 95% CI: 3.433-9.795, respectively) and biologic treatment in Galicia (OR 6.329, 95% CI: 2.641-15.166). Younger patients presented a severe course at onset with more frequent use of immunosuppressors in both countries. Conclusions: In a large population of UC patients from two independent southern European countries, most patients did not require aggressive therapy, but extensive colitis was a clear risk factor for more severe disease.

Original languageEnglish
Pages (from-to)1227-1238
Number of pages12
JournalInflammatory Bowel Diseases
Volume16
Issue number7
DOIs
Publication statusPublished - 24 Jun 2010

Keywords

  • Biologic treatment
  • Clinical activity
  • Galicia
  • Immunosuppression
  • Montreal Classification
  • Portugal
  • Predictive factors
  • Southern Europe
  • Ulcerative colitis

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