Ulcerative colitis in northern Portugal and Galicia in Spain

Manuel Barreiro-De Acosta; Fernando Magro; Daniel Carpio; Paula Lago; Ana Echarri; José Cotter; Santos Pereira; Raquel Gonçalves; Aurelio Lorenzo; Laura Carvalho; Javier Castro; Luisa Barros; Jorge Amil Dias; Susana Rodrigues; Francisco Portela; Camila Dias; Altamiro Da Costa-Pereira; María Victoria Alvaréz; Pedro Carpintero; Lucía Dancausa; María Luisa De Castro; Alberto Fernández Villaverde; Vicent Hernández; David Martínez Ares; Jesús Martínez Cadilla; Virginia Ollero; José Ignacio Rodríguez Prada; Eva Santos; Ramón Vázquez Dourado; Pablo Vega; Amadeu Corte Real Nunes; Ana Isabel Valente; Ana Isabel Vieira; Antónia Duarte; António Marques; Antonio Queiroz; Bernardino Ribeiro; Carolina Duesca; Celeste Fátima Viveiros; Cidalina Caetano; Claudia Sequeira; David Horta; Edgar Gencsi; Estela Monteiro; Filipe Gomes Silva; Glória Marinho; Helder Cardoso; Helena Vasconcelos; Helena Sousa; Henrique Morna; Horácio Lopes; Isabel Bastos; Isabel Medeiros; Isabel Seves; Isadora Rosa; João Baranda; João Ramos De Deus; J. Godinho Lopes; João Freitas; J. Pinto De Matos; Jorge Reis; Jorge Vieira; José Estevens; J. M. Ribeiro; Leopoldo Matos; Luís Correia; Luís Jasmins; Luis Lebre; Luísa Gloria; Lurdes Tavares; Marília Cravo; Margarida Marques; Marie Isabelle Cremers; Maria Do Rosário Maldonado; Manuel Correia; Maria De Lurdes Gonçalves; Mário César; Miguel Areia; Manuela Ferreira; Mário Júlio Campos; Marta Salgado; Nuno Almeida; Paulo Andrade; Paula Ministro; Paula Moura Santos; Paula Peixe; Paulo Caldeira; Paulo Freire; Pedro Martins; Ricardo Ferreira; Ricardo Freire; Rui Loureiro; Rui Sousa; Rute Cerqueira; Salazar Sousa; Salomé Costa Lima; Sara Folgado Alberto; Silvia Leite; Sofia Mendes; Sónia Barroso; Sandra Lopes; Sónia Nobre; Tiago Bana E Costa; Vítor Fernandes

doi:10.1002/ibd.21170

Ulcerative colitis in northern Portugal and Galicia in Spain

Manuel Barreiro-De Acosta, Fernando Magro, Daniel Carpio, Paula Lago, Ana Echarri, José Cotter, Santos Pereira, Raquel Gonçalves, Aurelio Lorenzo, Laura Carvalho, Javier Castro, Luisa Barros, Jorge Amil Dias, Susana Rodrigues, Francisco Portela, Camila Dias, Altamiro Da Costa-Pereira, María Victoria Alvaréz, Pedro Carpintero, Lucía DancausaMaría Luisa De Castro, Alberto Fernández Villaverde, Vicent Hernández, David Martínez Ares, Jesús Martínez Cadilla, Virginia Ollero, José Ignacio Rodríguez Prada, Eva Santos, Ramón Vázquez Dourado, Pablo Vega, Amadeu Corte Real Nunes, Ana Isabel Valente, Ana Isabel Vieira, Antónia Duarte, António Marques, Antonio Queiroz, Bernardino Ribeiro, Carolina Duesca, Celeste Fátima Viveiros, Cidalina Caetano, Claudia Sequeira, David Horta, Edgar Gencsi, Estela Monteiro, Filipe Gomes Silva, Glória Marinho, Helder Cardoso, Helena Vasconcelos, Helena Sousa, Henrique Morna, Horácio Lopes, Isabel Bastos, Isabel Medeiros, Isabel Seves, Isadora Rosa, João Baranda, João Ramos De Deus, J. Godinho Lopes, João Freitas, J. Pinto De Matos, Jorge Reis, Jorge Vieira, José Estevens, J. M. Ribeiro, Leopoldo Matos, Luís Correia, Luís Jasmins, Luis Lebre, Luísa Gloria, Lurdes Tavares, Marília Cravo, Margarida Marques, Marie Isabelle Cremers, Maria Do Rosário Maldonado, Manuel Correia, Maria De Lurdes Gonçalves, Mário César, Miguel Areia, Manuela Ferreira, Mário Júlio Campos, Marta Salgado, Nuno Almeida, Paulo Andrade, Paula Ministro, Paula Moura Santos, Paula Peixe, Paulo Caldeira, Paulo Freire, Pedro Martins, Ricardo Ferreira, Ricardo Freire, Rui Loureiro, Rui Sousa, Rute Cerqueira, Salazar Sousa, Salomé Costa Lima, Sara Folgado Alberto, Silvia Leite, Sofia Mendes, Sónia Barroso, Sandra Lopes, Sónia Nobre, Tiago Bana E Costa, Vítor Fernandes

NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Background: Clinical and therapeutic patterns of ulcerative colitis (UC) are variable in different world regions. The purpose of this study was to examine two close independent southern European UC populations from 2 bordering countries and observe how demographic and clinical characteristics of patients can influence the severity of UC. Methods: A cross-sectional study was conducted during a 15-month period (September 2005 to December 2006) based on data of 2 Web registries of UC patients. Patients were stratified according to the Montreal Classification and disease severity was defined by the type of treatment taken. Results: A total of 1549 UC patients were included, 1008 (65%) from northern Portugal and 541 (35%) from Galicia (northwest Spain). A female predominance (57%) was observed in Portuguese patients (P < 0.001). The median age at diagnosis was 35 years and median years of disease was 7. The majority of patients (53%) were treated only with mesalamine, while 15% had taken immunosuppressant drugs, and 3% biologic treatment. Most patients in both groups were not at risk for aggressive therapy. Extensive colitis was a predictive risk factor for immunosuppression in northern Portugal and Galicia (odds ratio [OR] 2.737, 95% confidence interval [CI]: 1.846-4.058; OR 5.799, 95% CI: 3.433-9.795, respectively) and biologic treatment in Galicia (OR 6.329, 95% CI: 2.641-15.166). Younger patients presented a severe course at onset with more frequent use of immunosuppressors in both countries. Conclusions: In a large population of UC patients from two independent southern European countries, most patients did not require aggressive therapy, but extensive colitis was a clear risk factor for more severe disease.

Original language	English
Pages (from-to)	1227-1238
Number of pages	12
Journal	Inflammatory Bowel Diseases
Volume	16
Issue number	7
DOIs	https://doi.org/10.1002/ibd.21170
Publication status	Published - 24 Jun 2010

Keywords

Biologic treatment
Clinical activity
Galicia
Immunosuppression
Montreal Classification
Portugal
Predictive factors
Southern Europe
Ulcerative colitis

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Barreiro-De Acosta, M., Magro, F., Carpio, D., Lago, P., Echarri, A., Cotter, J., Pereira, S., Gonçalves, R., Lorenzo, A., Carvalho, L., Castro, J., Barros, L., Dias, J. A., Rodrigues, S., Portela, F., Dias, C., Da Costa-Pereira, A., Alvaréz, M. V., Carpintero, P., ... Fernandes, V. (2010). Ulcerative colitis in northern Portugal and Galicia in Spain. Inflammatory Bowel Diseases, 16(7), 1227-1238. https://doi.org/10.1002/ibd.21170

@article{fa58f93c10d448839c89b6a1efab3607,

title = "Ulcerative colitis in northern Portugal and Galicia in Spain",

abstract = "Background: Clinical and therapeutic patterns of ulcerative colitis (UC) are variable in different world regions. The purpose of this study was to examine two close independent southern European UC populations from 2 bordering countries and observe how demographic and clinical characteristics of patients can influence the severity of UC. Methods: A cross-sectional study was conducted during a 15-month period (September 2005 to December 2006) based on data of 2 Web registries of UC patients. Patients were stratified according to the Montreal Classification and disease severity was defined by the type of treatment taken. Results: A total of 1549 UC patients were included, 1008 (65%) from northern Portugal and 541 (35%) from Galicia (northwest Spain). A female predominance (57%) was observed in Portuguese patients (P < 0.001). The median age at diagnosis was 35 years and median years of disease was 7. The majority of patients (53%) were treated only with mesalamine, while 15% had taken immunosuppressant drugs, and 3% biologic treatment. Most patients in both groups were not at risk for aggressive therapy. Extensive colitis was a predictive risk factor for immunosuppression in northern Portugal and Galicia (odds ratio [OR] 2.737, 95% confidence interval [CI]: 1.846-4.058; OR 5.799, 95% CI: 3.433-9.795, respectively) and biologic treatment in Galicia (OR 6.329, 95% CI: 2.641-15.166). Younger patients presented a severe course at onset with more frequent use of immunosuppressors in both countries. Conclusions: In a large population of UC patients from two independent southern European countries, most patients did not require aggressive therapy, but extensive colitis was a clear risk factor for more severe disease.",

keywords = "Biologic treatment, Clinical activity, Galicia, Immunosuppression, Montreal Classification, Portugal, Predictive factors, Southern Europe, Ulcerative colitis",

author = "{Barreiro-De Acosta}, Manuel and Fernando Magro and Daniel Carpio and Paula Lago and Ana Echarri and Jos{\'e} Cotter and Santos Pereira and Raquel Gon{\c c}alves and Aurelio Lorenzo and Laura Carvalho and Javier Castro and Luisa Barros and Dias, {Jorge Amil} and Susana Rodrigues and Francisco Portela and Camila Dias and {Da Costa-Pereira}, Altamiro and Alvar{\'e}z, {Mar{\'i}a Victoria} and Pedro Carpintero and Luc{\'i}a Dancausa and {De Castro}, {Mar{\'i}a Luisa} and Villaverde, {Alberto Fern{\'a}ndez} and Vicent Hern{\'a}ndez and Ares, {David Mart{\'i}nez} and Cadilla, {Jes{\'u}s Mart{\'i}nez} and Virginia Ollero and Prada, {Jos{\'e} Ignacio Rodr{\'i}guez} and Eva Santos and Dourado, {Ram{\'o}n V{\'a}zquez} and Pablo Vega and Nunes, {Amadeu Corte Real} and Valente, {Ana Isabel} and Vieira, {Ana Isabel} and Ant{\'o}nia Duarte and Ant{\'o}nio Marques and Antonio Queiroz and Bernardino Ribeiro and Carolina Duesca and Viveiros, {Celeste F{\'a}tima} and Cidalina Caetano and Claudia Sequeira and David Horta and Edgar Gencsi and Estela Monteiro and Silva, {Filipe Gomes} and Gl{\'o}ria Marinho and Helder Cardoso and Helena Vasconcelos and Helena Sousa and Henrique Morna and Hor{\'a}cio Lopes and Isabel Bastos and Isabel Medeiros and Isabel Seves and Isadora Rosa and Jo{\~a}o Baranda and {De Deus}, {Jo{\~a}o Ramos} and Lopes, {J. Godinho} and Jo{\~a}o Freitas and {De Matos}, {J. Pinto} and Jorge Reis and Jorge Vieira and Jos{\'e} Estevens and Ribeiro, {J. M.} and Leopoldo Matos and Lu{\'i}s Correia and Lu{\'i}s Jasmins and Luis Lebre and Lu{\'i}sa Gloria and Lurdes Tavares and Mar{\'i}lia Cravo and Margarida Marques and Cremers, {Marie Isabelle} and Maldonado, {Maria Do Ros{\'a}rio} and Manuel Correia and {De Lurdes Gon{\c c}alves}, Maria and M{\'a}rio C{\'e}sar and Miguel Areia and Manuela Ferreira and Campos, {M{\'a}rio J{\'u}lio} and Marta Salgado and Nuno Almeida and Paulo Andrade and Paula Ministro and Santos, {Paula Moura} and Paula Peixe and Paulo Caldeira and Paulo Freire and Pedro Martins and Ricardo Ferreira and Ricardo Freire and Rui Loureiro and Rui Sousa and Rute Cerqueira and Salazar Sousa and Lima, {Salom{\'e} Costa} and Alberto, {Sara Folgado} and Silvia Leite and Sofia Mendes and S{\'o}nia Barroso and Sandra Lopes and S{\'o}nia Nobre and {Bana E Costa}, Tiago and V{\'i}tor Fernandes",

year = "2010",

month = jun,

day = "24",

doi = "10.1002/ibd.21170",

language = "English",

volume = "16",

pages = "1227--1238",

journal = "Inflammatory Bowel Diseases",

issn = "1078-0998",

publisher = "Lippincott, Williams & Wilkins",

number = "7",

}

Barreiro-De Acosta, M, Magro, F, Carpio, D, Lago, P, Echarri, A, Cotter, J, Pereira, S, Gonçalves, R, Lorenzo, A, Carvalho, L, Castro, J, Barros, L, Dias, JA, Rodrigues, S, Portela, F, Dias, C, Da Costa-Pereira, A, Alvaréz, MV, Carpintero, P, Dancausa, L, De Castro, ML, Villaverde, AF, Hernández, V, Ares, DM, Cadilla, JM, Ollero, V, Prada, JIR, Santos, E, Dourado, RV, Vega, P, Nunes, ACR, Valente, AI, Vieira, AI, Duarte, A, Marques, A, Queiroz, A, Ribeiro, B, Duesca, C, Viveiros, CF, Caetano, C, Sequeira, C, Horta, D, Gencsi, E, Monteiro, E, Silva, FG, Marinho, G, Cardoso, H, Vasconcelos, H, Sousa, H, Morna, H, Lopes, H, Bastos, I, Medeiros, I, Seves, I, Rosa, I, Baranda, J, De Deus, JR, Lopes, JG, Freitas, J, De Matos, JP, Reis, J, Vieira, J, Estevens, J, Ribeiro, JM, Matos, L, Correia, L, Jasmins, L, Lebre, L, Gloria, L, Tavares, L, Cravo, M, Marques, M, Cremers, MI, Maldonado, MDR, Correia, M, De Lurdes Gonçalves, M, César, M, Areia, M, Ferreira, M, Campos, MJ, Salgado, M, Almeida, N, Andrade, P, Ministro, P, Santos, PM, Peixe, P, Caldeira, P, Freire, P, Martins, P , Ferreira, R, Freire, R, Loureiro, R, Sousa, R, Cerqueira, R, Sousa, S, Lima, SC, Alberto, SF, Leite, S, Mendes, S, Barroso, S, Lopes, S, Nobre, S, Bana E Costa, T & Fernandes, V 2010, 'Ulcerative colitis in northern Portugal and Galicia in Spain', Inflammatory Bowel Diseases, vol. 16, no. 7, pp. 1227-1238. https://doi.org/10.1002/ibd.21170

TY - JOUR

T1 - Ulcerative colitis in northern Portugal and Galicia in Spain

AU - Barreiro-De Acosta, Manuel

AU - Magro, Fernando

AU - Carpio, Daniel

AU - Lago, Paula

AU - Echarri, Ana

AU - Cotter, José

AU - Pereira, Santos

AU - Gonçalves, Raquel

AU - Lorenzo, Aurelio

AU - Carvalho, Laura

AU - Castro, Javier

AU - Barros, Luisa

AU - Dias, Jorge Amil

AU - Rodrigues, Susana

AU - Portela, Francisco

AU - Dias, Camila

AU - Da Costa-Pereira, Altamiro

AU - Alvaréz, María Victoria

AU - Carpintero, Pedro

AU - Dancausa, Lucía

AU - De Castro, María Luisa

AU - Villaverde, Alberto Fernández

AU - Hernández, Vicent

AU - Ares, David Martínez

AU - Cadilla, Jesús Martínez

AU - Ollero, Virginia

AU - Prada, José Ignacio Rodríguez

AU - Santos, Eva

AU - Dourado, Ramón Vázquez

AU - Vega, Pablo

AU - Nunes, Amadeu Corte Real

AU - Valente, Ana Isabel

AU - Vieira, Ana Isabel

AU - Duarte, Antónia

AU - Marques, António

AU - Queiroz, Antonio

AU - Ribeiro, Bernardino

AU - Duesca, Carolina

AU - Viveiros, Celeste Fátima

AU - Caetano, Cidalina

AU - Sequeira, Claudia

AU - Horta, David

AU - Gencsi, Edgar

AU - Monteiro, Estela

AU - Silva, Filipe Gomes

AU - Marinho, Glória

AU - Cardoso, Helder

AU - Vasconcelos, Helena

AU - Sousa, Helena

AU - Morna, Henrique

AU - Lopes, Horácio

AU - Bastos, Isabel

AU - Medeiros, Isabel

AU - Seves, Isabel

AU - Rosa, Isadora

AU - Baranda, João

AU - De Deus, João Ramos

AU - Lopes, J. Godinho

AU - Freitas, João

AU - De Matos, J. Pinto

AU - Reis, Jorge

AU - Vieira, Jorge

AU - Estevens, José

AU - Ribeiro, J. M.

AU - Matos, Leopoldo

AU - Correia, Luís

AU - Jasmins, Luís

AU - Lebre, Luis

AU - Gloria, Luísa

AU - Tavares, Lurdes

AU - Cravo, Marília

AU - Marques, Margarida

AU - Cremers, Marie Isabelle

AU - Maldonado, Maria Do Rosário

AU - Correia, Manuel

AU - De Lurdes Gonçalves, Maria

AU - César, Mário

AU - Areia, Miguel

AU - Ferreira, Manuela

AU - Campos, Mário Júlio

AU - Salgado, Marta

AU - Almeida, Nuno

AU - Andrade, Paulo

AU - Ministro, Paula

AU - Santos, Paula Moura

AU - Peixe, Paula

AU - Caldeira, Paulo

AU - Freire, Paulo

AU - Martins, Pedro

AU - Ferreira, Ricardo

AU - Freire, Ricardo

AU - Loureiro, Rui

AU - Sousa, Rui

AU - Cerqueira, Rute

AU - Sousa, Salazar

AU - Lima, Salomé Costa

AU - Alberto, Sara Folgado

AU - Leite, Silvia

AU - Mendes, Sofia

AU - Barroso, Sónia

AU - Lopes, Sandra

AU - Nobre, Sónia

AU - Bana E Costa, Tiago

AU - Fernandes, Vítor

PY - 2010/6/24

Y1 - 2010/6/24

N2 - Background: Clinical and therapeutic patterns of ulcerative colitis (UC) are variable in different world regions. The purpose of this study was to examine two close independent southern European UC populations from 2 bordering countries and observe how demographic and clinical characteristics of patients can influence the severity of UC. Methods: A cross-sectional study was conducted during a 15-month period (September 2005 to December 2006) based on data of 2 Web registries of UC patients. Patients were stratified according to the Montreal Classification and disease severity was defined by the type of treatment taken. Results: A total of 1549 UC patients were included, 1008 (65%) from northern Portugal and 541 (35%) from Galicia (northwest Spain). A female predominance (57%) was observed in Portuguese patients (P < 0.001). The median age at diagnosis was 35 years and median years of disease was 7. The majority of patients (53%) were treated only with mesalamine, while 15% had taken immunosuppressant drugs, and 3% biologic treatment. Most patients in both groups were not at risk for aggressive therapy. Extensive colitis was a predictive risk factor for immunosuppression in northern Portugal and Galicia (odds ratio [OR] 2.737, 95% confidence interval [CI]: 1.846-4.058; OR 5.799, 95% CI: 3.433-9.795, respectively) and biologic treatment in Galicia (OR 6.329, 95% CI: 2.641-15.166). Younger patients presented a severe course at onset with more frequent use of immunosuppressors in both countries. Conclusions: In a large population of UC patients from two independent southern European countries, most patients did not require aggressive therapy, but extensive colitis was a clear risk factor for more severe disease.

AB - Background: Clinical and therapeutic patterns of ulcerative colitis (UC) are variable in different world regions. The purpose of this study was to examine two close independent southern European UC populations from 2 bordering countries and observe how demographic and clinical characteristics of patients can influence the severity of UC. Methods: A cross-sectional study was conducted during a 15-month period (September 2005 to December 2006) based on data of 2 Web registries of UC patients. Patients were stratified according to the Montreal Classification and disease severity was defined by the type of treatment taken. Results: A total of 1549 UC patients were included, 1008 (65%) from northern Portugal and 541 (35%) from Galicia (northwest Spain). A female predominance (57%) was observed in Portuguese patients (P < 0.001). The median age at diagnosis was 35 years and median years of disease was 7. The majority of patients (53%) were treated only with mesalamine, while 15% had taken immunosuppressant drugs, and 3% biologic treatment. Most patients in both groups were not at risk for aggressive therapy. Extensive colitis was a predictive risk factor for immunosuppression in northern Portugal and Galicia (odds ratio [OR] 2.737, 95% confidence interval [CI]: 1.846-4.058; OR 5.799, 95% CI: 3.433-9.795, respectively) and biologic treatment in Galicia (OR 6.329, 95% CI: 2.641-15.166). Younger patients presented a severe course at onset with more frequent use of immunosuppressors in both countries. Conclusions: In a large population of UC patients from two independent southern European countries, most patients did not require aggressive therapy, but extensive colitis was a clear risk factor for more severe disease.

KW - Biologic treatment

KW - Clinical activity

KW - Galicia

KW - Immunosuppression

KW - Montreal Classification

KW - Portugal

KW - Predictive factors

KW - Southern Europe

KW - Ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=77953717409&partnerID=8YFLogxK

U2 - 10.1002/ibd.21170

DO - 10.1002/ibd.21170

M3 - Article

C2 - 19924807

AN - SCOPUS:77953717409

SN - 1078-0998

VL - 16

SP - 1227

EP - 1238

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

IS - 7

ER -

Ulcerative colitis in northern Portugal and Galicia in Spain

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