Two comparative clinical studies were carried out in patients with active ulcer confirmed by endoscopy in order to investigate the efficacy of dosmalfate compared to sucralfate in the healing and symptom relief of peptic ulcers. In the first study, the efficacy and tolerability of 1.5 g dosmalfate taken twice daily were compared with those of sucralfate in 183 patients with gastric ulcer during a treatment period of 28-56 days. In the second study, the same doses of dosmalfate were similarly compared with sucralfate in 305 patients with duodenal ulcer. Results from both studies confirmed that at the indicated doses dosmalfate had comparable efficacy in both healing and relieving symptoms of peptic ulcer (gastric or duodenal) than sucralfate. The clinical and biochemical tolerability of both drugs were excellent.(C) 2000 Prous Science.
|Number of pages||7|
|Journal||Drugs of Today|
|Issue number||SUPPL. A|
|Publication status||Published - 15 Jul 2000|