TY - JOUR
T1 - Two-column simulated moving-bed process for binary separation
AU - Rodrigues, Rui C. R.
AU - Canhoto, Tiago J. S. B.
AU - Araújo, João M. M.
AU - Mota, José P. B.
N1 - Support from FCT/MCES (Portugal), through project POCTI/EQU/39391/2001 and PhD grants (SFRH/BD) 13721/2003 and 19267/2004, is gratefully acknowledged.
PY - 2008/2/8
Y1 - 2008/2/8
N2 - A two-column simulated moving-bed system has been developed for binary separation. The system combines a flexible node design, robust pump configuration, and cyclic flow-rate modulation to exploit the benefits of simulated counter-current operation. The feasibility of the proposed two-column system is demonstrated on the linear separation of two nucleosides by reversed phase. Emphasis is given to the potentialities of the process compared to single-column batch chromatography with recycling for the same amount of stationary phase. The performance of the proposed two-column process is verified with laboratory-scale experiments and detailed simulations for different difficulties in separation and desorbent-to-feed ratios.
AB - A two-column simulated moving-bed system has been developed for binary separation. The system combines a flexible node design, robust pump configuration, and cyclic flow-rate modulation to exploit the benefits of simulated counter-current operation. The feasibility of the proposed two-column system is demonstrated on the linear separation of two nucleosides by reversed phase. Emphasis is given to the potentialities of the process compared to single-column batch chromatography with recycling for the same amount of stationary phase. The performance of the proposed two-column process is verified with laboratory-scale experiments and detailed simulations for different difficulties in separation and desorbent-to-feed ratios.
KW - Asynchronous port switching
KW - Flow-rate modulation
KW - Nucleoside separation
KW - Optimization
KW - Reversed phase
KW - Simulated moving bed
KW - Two-column chromatography
UR - http://www.scopus.com/inward/record.url?scp=38349023166&partnerID=8YFLogxK
U2 - 10.1016/j.chroma.2007.11.106
DO - 10.1016/j.chroma.2007.11.106
M3 - Article
C2 - 18154982
AN - SCOPUS:38349023166
SN - 0021-9673
VL - 1180
SP - 42
EP - 52
JO - Journal Of Chromatography A
JF - Journal Of Chromatography A
IS - 1-2
ER -