Two-column simulated moving-bed process for binary separation

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16 Citations (Scopus)

Abstract

A two-column simulated moving-bed system has been developed for binary separation. The system combines a flexible node design, robust pump configuration, and cyclic flow-rate modulation to exploit the benefits of simulated counter-current operation. The feasibility of the proposed two-column system is demonstrated on the linear separation of two nucleosides by reversed phase. Emphasis is given to the potentialities of the process compared to single-column batch chromatography with recycling for the same amount of stationary phase. The performance of the proposed two-column process is verified with laboratory-scale experiments and detailed simulations for different difficulties in separation and desorbent-to-feed ratios.

Original languageEnglish
Pages (from-to)42-52
Number of pages11
JournalJournal Of Chromatography A
Volume1180
Issue number1-2
DOIs
Publication statusPublished - 8 Feb 2008

Keywords

  • Asynchronous port switching
  • Flow-rate modulation
  • Nucleoside separation
  • Optimization
  • Reversed phase
  • Simulated moving bed
  • Two-column chromatography

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