Two-column simulated moving-bed process for binary separation

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


A two-column simulated moving-bed system has been developed for binary separation. The system combines a flexible node design, robust pump configuration, and cyclic flow-rate modulation to exploit the benefits of simulated counter-current operation. The feasibility of the proposed two-column system is demonstrated on the linear separation of two nucleosides by reversed phase. Emphasis is given to the potentialities of the process compared to single-column batch chromatography with recycling for the same amount of stationary phase. The performance of the proposed two-column process is verified with laboratory-scale experiments and detailed simulations for different difficulties in separation and desorbent-to-feed ratios.

Original languageEnglish
Pages (from-to)42-52
Number of pages11
JournalJournal Of Chromatography A
Issue number1-2
Publication statusPublished - 8 Feb 2008


  • Asynchronous port switching
  • Flow-rate modulation
  • Nucleoside separation
  • Optimization
  • Reversed phase
  • Simulated moving bed
  • Two-column chromatography


Dive into the research topics of 'Two-column simulated moving-bed process for binary separation'. Together they form a unique fingerprint.

Cite this