Tumor start-up: mitochondrial fusion makes it happen

Ana R. Rebelo; Marcia Garcez; Catarina C.F. Homem

doi:10.15252/embj.2020106927

Tumor start-up: mitochondrial fusion makes it happen

Ana R. Rebelo, Marcia Garcez, Catarina C.F. Homem

Research output: Contribution to journal › Comment/debate › peer-review

1 Citation (Scopus)

Abstract

Whether changes in cellular metabolism precede tumor formation and trigger malignant properties or simply serve as a bioenergetic adaptation of cancer during disease progression remains debated. Bonnay et al (2020) now show that a metabolic reprogramming toward increased oxidative phosphorylation is required for irreversible cell immortalization and subsequent tumor formation.

Original language	English
Article number	e106927
Journal	Embo Journal
Volume	39
Issue number	23
Early online date	31 Oct 2020
DOIs	https://doi.org/10.15252/embj.2020106927
Publication status	Published - 1 Dec 2020

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title = "Tumor start-up: mitochondrial fusion makes it happen",

abstract = "Whether changes in cellular metabolism precede tumor formation and trigger malignant properties or simply serve as a bioenergetic adaptation of cancer during disease progression remains debated. Bonnay et al (2020) now show that a metabolic reprogramming toward increased oxidative phosphorylation is required for irreversible cell immortalization and subsequent tumor formation.",

author = "Rebelo, {Ana R.} and Marcia Garcez and Homem, {Catarina C.F.}",

year = "2020",

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T2 - mitochondrial fusion makes it happen

AU - Rebelo, Ana R.

AU - Garcez, Marcia

AU - Homem, Catarina C.F.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Whether changes in cellular metabolism precede tumor formation and trigger malignant properties or simply serve as a bioenergetic adaptation of cancer during disease progression remains debated. Bonnay et al (2020) now show that a metabolic reprogramming toward increased oxidative phosphorylation is required for irreversible cell immortalization and subsequent tumor formation.

AB - Whether changes in cellular metabolism precede tumor formation and trigger malignant properties or simply serve as a bioenergetic adaptation of cancer during disease progression remains debated. Bonnay et al (2020) now show that a metabolic reprogramming toward increased oxidative phosphorylation is required for irreversible cell immortalization and subsequent tumor formation.

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U2 - 10.15252/embj.2020106927

DO - 10.15252/embj.2020106927

M3 - Comment/debate

C2 - 33128782

AN - SCOPUS:85094969323

SN - 0261-4189

VL - 39

JO - Embo Journal

JF - Embo Journal

IS - 23

M1 - e106927

ER -

Tumor start-up: mitochondrial fusion makes it happen

Abstract

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