Trypanosoma brucei interaction with host: Mechanism of VSG release as target for drug discovery for african trypanosomiasis

Cláudia Jassica Gonçalves Moreno, Adriana Temporão, Taffarel Torres, Marcelo Sousa Silva

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The protozoan Trypanosoma brucei, responsible for animal and human trypanosomiasis, has a family of major surface proteases (MSPs) and phospholipase-C (PLC), both involved in some mechanisms of virulence during mammalian infections. During parasitism in the mammalian host, this protozoan is exclusively extracellular and presents a robust mechanism of antigenic variation that allows the persistence of infection. There has been incredible progress in our understanding of how variable surface glycoproteins (VSGs) are organised and expressed, and how expression is switched, particularly through recombination. The objective of this manuscript is to create a reflection about the mechanisms of antigenic variation in T. brucei, more specifically, in the process of variable surface glycoprotein (VSG) release. We firstly explore the mechanism of VSG release as a potential pathway and target for the development of anti-T. brucei drugs.

Original languageEnglish
Article number1484
JournalInternational Journal of Molecular Sciences
Volume20
Issue number6
DOIs
Publication statusPublished - 2 Mar 2019

Keywords

  • Antigenic variation
  • Major surface protease
  • Phospholipase-C
  • Trypanosoma brucei
  • Variable surface glycoprotein

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