TY - JOUR
T1 - Triacylglycerols accumulation and glycolipids secretion by the oleaginous yeast Rhodotorula babjevae Y-SL7
T2 - Structural identification and biotechnological applications
AU - Guerfali, Mohamed
AU - Ayadi, Ines
AU - Mohamed, Nadia
AU - Ayadi, Wajdi
AU - Belghith, Hafedh
AU - Bronze, Maria Rosário
AU - Ribeiro, Maria H.L.
AU - Gargouri, Ali
PY - 2019/2/1
Y1 - 2019/2/1
N2 - The newly isolated oleaginous yeast, Rhodotorula babjevae Y-SL7, was shown to accumulate high intracellular content of microbial oil (mainly triacylglycerols) and to secret, under the same culture conditions, an atypical glycolipid. This unusual behavior was induced when the strain was subjected to nitrogen limitation and high amount of carbon. A series of analytical methods was adopted in order to structurally characterize the secreted glycolipid. The latter consists of a mixture of 9 molecules formed by a polyol head group, bound through the carboxyl end of an acetylated 3-hydroxy fatty acid with C18 or C16 chain length. In addition of their physicochemical properties such as emulsifying activity on hydrophobic substrates, Y-SL7 glycolipids have shown a therapeutically promising cytotoxic effect against different cancer cell lines. In fact, Y-SL7 strain can be used for the production of triacylglycerols as energetic molecules and for the secretion of a biosurfactant of therapeutic and environmental interest.
AB - The newly isolated oleaginous yeast, Rhodotorula babjevae Y-SL7, was shown to accumulate high intracellular content of microbial oil (mainly triacylglycerols) and to secret, under the same culture conditions, an atypical glycolipid. This unusual behavior was induced when the strain was subjected to nitrogen limitation and high amount of carbon. A series of analytical methods was adopted in order to structurally characterize the secreted glycolipid. The latter consists of a mixture of 9 molecules formed by a polyol head group, bound through the carboxyl end of an acetylated 3-hydroxy fatty acid with C18 or C16 chain length. In addition of their physicochemical properties such as emulsifying activity on hydrophobic substrates, Y-SL7 glycolipids have shown a therapeutically promising cytotoxic effect against different cancer cell lines. In fact, Y-SL7 strain can be used for the production of triacylglycerols as energetic molecules and for the secretion of a biosurfactant of therapeutic and environmental interest.
KW - Biosurfactant
KW - Cancer cell lines
KW - Glycolipids
KW - Microbial lipid
KW - Rhodotorula babjevae
UR - http://www.scopus.com/inward/record.url?scp=85056466569&partnerID=8YFLogxK
U2 - 10.1016/j.biortech.2018.11.036
DO - 10.1016/j.biortech.2018.11.036
M3 - Article
C2 - 30448685
AN - SCOPUS:85056466569
VL - 273
SP - 326
EP - 334
JO - Bioresource Technology
JF - Bioresource Technology
SN - 0960-8524
ER -