Triacylglycerols accumulation and glycolipids secretion by the oleaginous yeast Rhodotorula babjevae Y-SL7: Structural identification and biotechnological applications

Mohamed Guerfali, Ines Ayadi, Nadia Mohamed, Wajdi Ayadi, Hafedh Belghith, Maria Rosário Bronze, Maria H.L. Ribeiro, Ali Gargouri

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The newly isolated oleaginous yeast, Rhodotorula babjevae Y-SL7, was shown to accumulate high intracellular content of microbial oil (mainly triacylglycerols) and to secret, under the same culture conditions, an atypical glycolipid. This unusual behavior was induced when the strain was subjected to nitrogen limitation and high amount of carbon. A series of analytical methods was adopted in order to structurally characterize the secreted glycolipid. The latter consists of a mixture of 9 molecules formed by a polyol head group, bound through the carboxyl end of an acetylated 3-hydroxy fatty acid with C18 or C16 chain length. In addition of their physicochemical properties such as emulsifying activity on hydrophobic substrates, Y-SL7 glycolipids have shown a therapeutically promising cytotoxic effect against different cancer cell lines. In fact, Y-SL7 strain can be used for the production of triacylglycerols as energetic molecules and for the secretion of a biosurfactant of therapeutic and environmental interest.

Original languageEnglish
Pages (from-to)326-334
Number of pages9
JournalBioresource Technology
Volume273
DOIs
Publication statusPublished - 1 Feb 2019

Keywords

  • Biosurfactant
  • Cancer cell lines
  • Glycolipids
  • Microbial lipid
  • Rhodotorula babjevae

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