Transmission potential of antimony-resistant leishmania field isolates

Veronika Seblova, Bruno Oury, Naouel Eddaikra, Khatima Aït-Oudhia, Francine Pratlong, Elodie Gazanion, Carla Maia, Petr Volf, Denis Sereno

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We studied the development of antimony-resistant Leishmania infantum in natural vectors Lutzomyia longipalpis and Phlebotomus perniciosus to ascertain the risk of parasite transmission by sand flies. All three resistant strains produced fully mature late-stage infections in sand flies; moreover, the resistant phenotype was maintained after the passage through the vector. These results highlight the risk of circulation of resistant Leishmania strains and question the use of human drugs for treatment of dogs as Leishmania reservoirs. Copyright

Original languageEnglish
Pages (from-to)6273-6276
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume58
Issue number10
DOIs
Publication statusPublished - 1 Oct 2014

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