@article{a936dabd25974a4f84925d341a05ef89,
title = "Toxicokinetics of waterborne trivalent arsenic in the freshwater bivalve corbicula fluminea",
abstract = "Arsenite (AsIII) uptake and elimination kinetics were studied in a freshwater bivalve, Corbicula fluminea, exposed to several nominal concentrations of AsIII (0, 100, 300, 500, and 1000 μg L -1) in a static 28-day assay, followed by a depuration stage of 14 days. At the end of each sampling time (days 0, 7, 28, and 42) whole-body portions were surveyed for total As concentrations and, complimentarily, surveyed for whole-body metallothionein (MT) induction to assess its role as a defense mechanism against exposure to AsIII. Histochemical evaluation of the digestive gland was performed to verify As deposition and elimination in the tissue. Results show a significant increase in whole-body total As after 28 days of exposure for all treatments, followed by a decrease at the end of the depuration phase. Biodynamic kinetic models for As uptake and elimination were obtained from bioaccumulation data during the exposure phase, for all As treatments, by estimating uptake and elimination rate constants. Bioconcentration factors (BCFs) were estimated by the ratio of these constants. Results revealed that exposure to higher concentrations of AsIII causes a decrease in BCFs, suggesting that C. fluminea triggers effective regulatory mechanisms when exposed to higher concentrations of the metalloid. Significant induction of MT was detected during the exposure phase, followed by a decrease in MT concentration to control levels after depuration for all treatments. No significant differences in MT concentrations were observed between treatments. This finding may confirm the role of MT as part of the As regulation process, but its independence relative to concentrations of As III in water suggests that MT induction is not dose dependent. The histochemical evaluation provided clear evidence that As was effectively accumulated in the digestive gland during exposure and eliminated during depuration. The present work demonstrated that C. fluminea is capable of regulating As, even at exposures as high as 1000 μg L-1 of waterborne AsIII. {\textcopyright} 2008 Springer Science+Business Media, LLC.",
keywords = "arsenic, fresh water, metallothionein, arsenite, bivalve, coccolith, concentration (composition), defense mechanism, dose-response relationship, modeling, pollution exposure, toxicity, article, bioaccumulation, concentration (parameters), Corbicula, Corbicula fluminea, environmental exposure, exocrine gland, freshwater environment, histochemistry, nonhuman, priority journal, regulatory mechanism, toxicokinetics, water pollution, water sampling, Algorithms, Animals, Arsenicals, Digestive System, Fresh Water, Metallothionein, Models, Biological, Water Pollutants, Chemical, Bivalvia",
author = "Costa, {Pedro M.} and H.M. Santos and I. Peres and M.H. Costa and Capelo-Martinez, {J. L.} and M.S. Diniz",
note = "Cited By :9 Export Date: 7 May 2017 CODEN: AECTC Correspondence Address: Costa, P. M.; IMAR-Instituto Do Mar, Departamento de Ci{\^e}ncias e Engenharia Do Ambiente, Universidade Nova de Lisboa, Quinta da Torre, Caparica 2829-516, Portugal; email: pmcosta@fct.unl.pt Chemicals/CAS: arsenic, 7440-38-2; Arsenicals; Metallothionein, 9038-94-2; Water Pollutants, Chemical References: Amiard, J.-C., Amiard-Triquet, C., Barka, S., Pellerin, J., Rainbow, P.S., Metallothioneins in aquatic invertebrates: Their role in metal detoxification and their use as biomarkers Aquatic Toxicology, 76 (2), pp. 160-202. , DOI 10.1016/j.aquatox.2005.08.015, PII S0166445X05003279; Apeti, D.A., Johnson, E., Robinson, L., A model for bioaccumulation of metals in Crassostrea virginica from Apalachicola Bay, Florida Am J Environ Sci, 1, pp. 239-248; Aposhian, H.V., Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity Annu Rev Pharmacol Toxicol, 37, pp. 397-419. , 10.1146/annurev.pharmtox.37.1.397; Aposhian, H.V., Aposhian, M.M., Arsenic toxicology: Five questions Chemical Research in Toxicology, 19 (1), pp. 1-15. , DOI 10.1021/tx050106d; Bailer, A.J., Walker, S.E., Venis, K., Estimating and testing bioconcentration factors Environ Toxicol Chem, 19, pp. 2338-2340. , 10.1897/1551-5028(2000)019<2338:EATBF>2.3.CO;2; Baudrimont, M., Metivaud, J., Maury-Brachet, R., Ribeyre, F., Boudou, A., Bioaccumulation and metallothionein response in the asiatic clam (Corbicula fluminea) after experimental exposure to cadmium and inorganic mercury Environmental Toxicology and Chemistry, 16 (10), pp. 2096-2105. , DOI 10.1897/1551-5028(1997)016<2096:BAMRIT>2.3.CO;2; Baudrimont, M., Lemaire-Gony, S., Ribeyre, F., Metivaud, J., Boudou, A., Seasonal variations of metallothionein concentrations in the Asiatic clam (Corbicula fluminea) Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology, 118 (3), pp. 361-367. , DOI 10.1016/S0742-8413(97)00157-6, PII S0742841397001576; Baudrimont, M., Andres, S., Metivaud, J., Lapaquellerie, Y., Ribeyre, F., Maillet, N., Latouche, C., Boudou, A., Field transplantation of the freshwater bivalve Corbicula fluminea along a polymetallic contamination gradient (River Lot, France): II. Metallothionein response to metal exposure Environmental Toxicology and Chemistry, 18 (11), pp. 2472-2477. , DOI 10.1897/1551-5028(1999)018<2472:FTOTFB>2.3.CO;2; Baudrimont, M., Andres, S., Durrieu, G., Boudou, A., The key role of metallothioneins in the bivalve Corbicula fluminea during the depuration phase, after in situ exposure to Cd and Zn Aquatic Toxicology, 63 (2), pp. 89-102. , DOI 10.1016/S0166-445X(02)00134-0, PII S0166445X02001340; Bissen, M., Frimmel, F.H., Arsenic - A review. Part I: Occurrence, toxicity, speciation, mobility Acta Hydrochimica et Hydrobiologica, 31 (1), pp. 9-18. , DOI 10.1002/aheh.200390025; Bissen, M., Frimmel, F.H., Arsenic - A review. Part II: Oxidation of arsenic and its removal in water treatment Acta Hydrochimica et Hydrobiologica, 31 (2), pp. 97-107. , DOI 10.1002/aheh.200300485; Bryan, G.W., Langston, W.J., Hummerstone, L.G., Burt, G.R., A Guide to the assessment of heavy-metal contamination in estuaries using biological indicators Mar Biol Assoc UK, , Occasional Publication No. 4; Cervantes, C., Ji, G., Ramirez, J.L., Silver, S., Resistance to arsenic compounds in microorganisms FEMS Microbiol Rev, 15, pp. 355-367. , 10.1111/j.1574-6976.1994.tb00145.x; Couillard, Y., Campbell, P.G.C., Tessier, A., Response of metallothionein concentrations in a freshwater bivalve (Anodonta grandis) along an environmental cadmium gradient Mol Mar Biol Biotech, 2, pp. 299-313; De Kock, W.C., Kramer, K.J.M., Kramer, K.J.M., Active biomonitoring (ABM) by translocation of bivalve molluscs Biomonitoring of Coastal Waters and Estuaries, pp. 51-84. , CRC Press Boca Raton, FL; Diniz, M.S., Santos, H.M., Costa, P.M., Peres, I., Costa, M.H., Capelo, J.L., Metallothionein responses in the Asiatic clam (Corbicula fluminea) after exposure to trivalent arsenic Biomarkers, 12 (6), pp. 589-598. , DOI 10.1080/13547500701507701, PII 780335047; Duker, A.A., Carranza, E.J.M., Hale, M., Arsenic geochemistry and health Environment International, 31 (5), pp. 631-641. , DOI 10.1016/j.envint.2004.10.020, PII S0160412004001953; Feng, Z., Xia, Y., Tian, D., Wu, K., Schmitt, M., Kwok, R.K., Mumford, J.L., DNA damage in buccal epithelial cells from individuals chronically exposed to arsenic via drinking water in Inner Mongolia, China Anticancer Research, 21 (A), pp. 51-58; Fraysse, B., Baudin, J.-P., Garnier-Laplace, J., Adam, C., Boudou, A., Effects of Cd and Zn waterborne exposure on the uptake and depuration of 57Co, 110mAg and 134Cs by the Asiatic clam (Corbicula fluminea) and the zebra mussel (Dreissena polymorpha) - Whole organism study Environmental Pollution, 118 (3), pp. 297-306. , DOI 10.1016/S0269-7491(01)00305-0, PII S0269749101003050; Hindmarsh, J.T., Arsenic, its clinical and environmental significance Journal of Trace Elements in Experimental Medicine, 13 (1), pp. 165-172. , DOI 10.1002/(SICI)1520-670X(2000)13:1<165::AID-JTRA17>3.0.CO;2-R; Hossain, F., Sivakumar, B., Spatial pattern of arsenic contamination in shallow wells of Bangladesh: Regional geology and nonlinear dynamics Stochastic Environmental Research and Risk Assessment, 20 (1-2), pp. 66-76. , DOI 10.1007/s00477-005-0012-7; Inza, B., Ribeyre, F., Maury-Brachet, R., Boudou, A., Tissue distribution of inorganic mercury, methylmercury and cadmium in the Asiatic clam (Corbicula fluminea) in relation to the contamination levels of the water column and sediment Chemosphere, 35 (12), pp. 2817-2836. , DOI 10.1016/S0045-6535(97)00342-1, PII S0045653597003421; Jiang, G., Gong, Z., Li, X.-F., Cullen, W.R., Le, X.C., Interaction of trivalent arsenicals with metallothionein Chem Res Toxicol, 16, pp. 873-880. , 10.1021/tx034053g; Jonhs, C., Luoma, S.N., Arsenic in benthic bivalves of San Francisco Bay and the Sacramento/San Joaquin River Sci Tot Environ, 97 (98), pp. 673-684. , 10.1016/0048-9697(90)90268-Y; Kaise, T., Horiguchi, Y., Fukui, S., Shiomi, K., Chino, M., Kikuchi, T., Acute toxicity and metabolism of arsenocholine in mice Appl Organomet Chem, 6, pp. 369-373. , 10.1002/aoc.590060410; Liao, C.-M., Ling, M.P., Assessment of human health risks for arsenic bioaccumulation in tilapia (Oreochromis mossambicus) and large-scale mullet (Liza macrolepis) from blackfoot disease area in Taiwan Archives of Environmental Contamination and Toxicology, 45 (2), pp. 264-272. , DOI 10.1007/s00244-003-0107-4; Lillie, R.D., Histopathologic Technic and Practical Histochemistry, , McGraw-Hill New York; Luoma, S.N., Rainbow, P.S., Why is metal bioaccumulation so variable? Biodynamics as a unifying concept Environmental Science and Technology, 39 (7), pp. 1921-1931. , DOI 10.1021/es048947e; Mandal, B.K., Suzuki, K.T., Arsenic round the world: A review Talanta, 58 (1), pp. 201-235. , DOI 10.1016/S0039-9140(02)00268-0, PII S0039914002002680; Martoja, R., Martoja, M., Initiation Aux Tecniques de l'Histologie Animal, , Masson Paris; McGeer, J.C., Brix, K.V., Skeaff, J.M., Deforest, D.K., Brigham, S.I., Adams, W.J., Green, A., Inverse relationship between bioconcentration factor and exposure concentration for metals: Implications for hazard assessment of metals in the aquatic environment Environmental Toxicology and Chemistry, 22 (5), pp. 1017-1037. , DOI 10.1897/1551-5028(2003)022<1017:IRBBFA>2.0.CO;2; Mouthon, J., Sur la presence en France et au Portugal de Corbicula (Bivalvia, Corbiculidae) originaire d'Asie Basteria, 45, pp. 109-116; Ngu, T.T., Stillman, M.J., Arsenic binding to human metallothionein Journal of the American Chemical Society, 128 (38), pp. 12473-12483. , DOI 10.1021/ja062914c; Orescanin, V., Lovrencic, I., Mikelic, L., Barisic, D., Matasin, Z., Lulic, S., Pezelj, D., Biomonitoring of heavy metals and arsenic on the east coast of the Middle Adriatic Sea using Mytilus galloprovincialis Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 245 (2), pp. 495-500. , DOI 10.1016/j.nimb.2005.11.050, PII S0168583X05019683; Palecek, E., Pechan, Z., Estimation of nanogram quantities of proteins by pulse polarographic techniques Anal Biochem, 42, pp. 59-71. , 10.1016/0003-2697(71)90010-8; Ravera, O., Monitoring of the aquatic environment by species accumulator of pollutants: A review J Limnol, 60 (S1), pp. 63-78; Roesijadi, G., Metallothionein and its role in toxic metal regulation Comp Biochem Physiol, 113, pp. 117-123; Romero-Isart, N., Vasak, M., Advances in the structure and chemistry of metallothioneins Journal of Inorganic Biochemistry, 88 (3-4), pp. 388-396. , DOI 10.1016/S0162-0134(01)00347-6, PII S0162013401003476; Santos, H.M., Diniz, M.S., Costa, P.M., Peres, I., Costa, M.H., Alves, S., Capelo, J.L., Toxicological effects and bioaccumulation in the freshwater clam (Corbicula fluminea) following exposure to trivalent arsenic Environmental Toxicology, 22 (5), pp. 502-509. , DOI 10.1002/tox.20303; Sebesvari, Z., Friederike Ettwig, K., Emons, H., Biomonitoring of tin and arsenic in different compartments of a limnic ecosystem with emphasis on Corbicula fluminea and Dikerogammarus villosus Journal of Environmental Monitoring, 7 (3), pp. 203-207. , DOI 10.1039/b410717a; Sheskin, F.J., Handbook of Parametric and Nonparametric Statistical Procedures. 2nd Ed, , Chapman & Hall Boca Raton, FL; Thompson, J.A.J., Cosson, R.P., An improved electrochemical method for the quantification of metallothioneins in marine organisms Mar Environ Res, 11, pp. 137-152. , 10.1016/0141-1136(84)90027-8; Toyama, M., Yamashita, M., Hirayama, N., Murooka, Y., Interactions of arsenic with human metallothionein-2 J Biochem Tokyo, 132, pp. 217-221; Valette-Silver, N.J., Riedel, G.F., Crecelius, E.A., Windom, H., Smith, R.G., Dolvin, S.S., Elevated arsenic concentrations in bivalves from the southeast coasts of the USA Marine Environmental Research, 48 (4-5), pp. 311-333. , DOI 10.1016/S0141-1136(99)00057-4, PII S0141113699000574; Viarengo, A., Nott, J.A., Mechanisms of heavy metal cation homeostasis in marine invertebrates Comp Bioch Phys, 104, pp. 355-372; Viarengo, A., Moore, M.N., Mancinelli, G., Metallothioneins and lysosomes in metal toxicity and accumulation in marine mussels: The effect of cadmium in the presence and absence of phenanthrene Marine Biology, 94 (2), pp. 251-257. , DOI 10.1007/BF00392937; Viarengo, A., Burlando, B., Dondero, F., Marro, A., Fabbri, R., Metallothionein as a tool in biomonitoring programmes Biomarkers, 4, pp. 455-466. , 10.1080/135475099230615",
year = "2009",
month = aug,
doi = "10.1007/s00244-008-9267-6",
language = "English",
volume = "57",
pages = "338--347",
journal = "Archives of Environmental Contamination and Toxicology",
issn = "0090-4341",
publisher = "Springer Science Business Media",
number = "2",
}
