Towards the development of multifunctional chitosan-based iron oxide nanoparticles: Optimization and modelling of doxorubicin release

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15 Citations (Scopus)

Abstract

In the present work composite nanoparticles with a magnetic core and a chitosan-based shell were produced as drug delivery systems for doxorubicin (DOX). The results show that composite nanoparticles with a hydrodynamic diameter within the nanometric range are able to encapsulate more DOX than polymeric nanoparticles alone corresponding also to a higher drug release. Moreover the synthesis method of the iron oxide nanoparticles influences the total amount of DOX released and a high content of iron oxide nanoparticles inhibits DOX release. The modelling of the experimental results revealed a release mechanism dominated by Fickian diffusion.

Original languageEnglish
Pages (from-to)212-221
Number of pages10
JournalCarbohydrate Polymers
Volume153
DOIs
Publication statusPublished - 20 Nov 2016

Keywords

  • Chitosan
  • Doxorubicin
  • Drug delivery
  • Iron oxide nanoparticles
  • Mathematical modelling
  • O-HTCC

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