Towards the development of multifunctional chitosan-based iron oxide nanoparticles: Optimization and modelling of doxorubicin release

Paula I P Soares; Ana Isabel Sousa; Isabel M M Ferreira; Carlos M M Novo; João Paulo Borges

doi:10.1016/j.carbpol.2016.07.109

Towards the development of multifunctional chitosan-based iron oxide nanoparticles: Optimization and modelling of doxorubicin release

Paula I P Soares, Ana Isabel Sousa, Isabel M M Ferreira, Carlos M M Novo, João Paulo Borges

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

In the present work composite nanoparticles with a magnetic core and a chitosan-based shell were produced as drug delivery systems for doxorubicin (DOX). The results show that composite nanoparticles with a hydrodynamic diameter within the nanometric range are able to encapsulate more DOX than polymeric nanoparticles alone corresponding also to a higher drug release. Moreover the synthesis method of the iron oxide nanoparticles influences the total amount of DOX released and a high content of iron oxide nanoparticles inhibits DOX release. The modelling of the experimental results revealed a release mechanism dominated by Fickian diffusion.

Original language	English
Pages (from-to)	212-221
Number of pages	10
Journal	Carbohydrate Polymers
Volume	153
DOIs	https://doi.org/10.1016/j.carbpol.2016.07.109
Publication status	Published - 20 Nov 2016

Keywords

Chitosan
Doxorubicin
Drug delivery
Iron oxide nanoparticles
Mathematical modelling
O-HTCC

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10.1016/j.carbpol.2016.07.109Licence: CC BY-NC-ND

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title = "Towards the development of multifunctional chitosan-based iron oxide nanoparticles: Optimization and modelling of doxorubicin release",

abstract = "In the present work composite nanoparticles with a magnetic core and a chitosan-based shell were produced as drug delivery systems for doxorubicin (DOX). The results show that composite nanoparticles with a hydrodynamic diameter within the nanometric range are able to encapsulate more DOX than polymeric nanoparticles alone corresponding also to a higher drug release. Moreover the synthesis method of the iron oxide nanoparticles influences the total amount of DOX released and a high content of iron oxide nanoparticles inhibits DOX release. The modelling of the experimental results revealed a release mechanism dominated by Fickian diffusion.",

keywords = "Chitosan, Doxorubicin, Drug delivery, Iron oxide nanoparticles, Mathematical modelling, O-HTCC",

author = "Soares, {Paula I P} and Sousa, {Ana Isabel} and Ferreira, {Isabel M M} and Novo, {Carlos M M} and Borges, {Jo{\~a}o Paulo}",

note = "Sem PDF. info:eu-repo/grantAgreement/FCT/5876/147333/PT# info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F81711%2F2011/PT# This work is funded by FEDER funds through the COMPETE 2020 Program and National Funds through FCT-Portuguese Foundation for Science and Technology under the project number POCI-01-0145-FEDER-007688, Reference UID/CTM/50025. P.I.P. Soares acknowledges FCT for PhD grant SFRH/BD/81711/2011.",

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doi = "10.1016/j.carbpol.2016.07.109",

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T2 - Optimization and modelling of doxorubicin release

AU - Soares, Paula I P

AU - Sousa, Ana Isabel

AU - Ferreira, Isabel M M

AU - Novo, Carlos M M

AU - Borges, João Paulo

N1 - Sem PDF. info:eu-repo/grantAgreement/FCT/5876/147333/PT# info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F81711%2F2011/PT# This work is funded by FEDER funds through the COMPETE 2020 Program and National Funds through FCT-Portuguese Foundation for Science and Technology under the project number POCI-01-0145-FEDER-007688, Reference UID/CTM/50025. P.I.P. Soares acknowledges FCT for PhD grant SFRH/BD/81711/2011.

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Y1 - 2016/11/20

N2 - In the present work composite nanoparticles with a magnetic core and a chitosan-based shell were produced as drug delivery systems for doxorubicin (DOX). The results show that composite nanoparticles with a hydrodynamic diameter within the nanometric range are able to encapsulate more DOX than polymeric nanoparticles alone corresponding also to a higher drug release. Moreover the synthesis method of the iron oxide nanoparticles influences the total amount of DOX released and a high content of iron oxide nanoparticles inhibits DOX release. The modelling of the experimental results revealed a release mechanism dominated by Fickian diffusion.

AB - In the present work composite nanoparticles with a magnetic core and a chitosan-based shell were produced as drug delivery systems for doxorubicin (DOX). The results show that composite nanoparticles with a hydrodynamic diameter within the nanometric range are able to encapsulate more DOX than polymeric nanoparticles alone corresponding also to a higher drug release. Moreover the synthesis method of the iron oxide nanoparticles influences the total amount of DOX released and a high content of iron oxide nanoparticles inhibits DOX release. The modelling of the experimental results revealed a release mechanism dominated by Fickian diffusion.

KW - Chitosan

KW - Doxorubicin

KW - Drug delivery

KW - Iron oxide nanoparticles

KW - Mathematical modelling

KW - O-HTCC

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VL - 153

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EP - 221

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

ER -

Towards the development of multifunctional chitosan-based iron oxide nanoparticles: Optimization and modelling of doxorubicin release

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Keywords

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