Toward system-level understanding of baculovirus–host cell interactions: from molecular fundamental studies to large-scale proteomics approaches

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Abstract

Baculovirusesareinsectvirusesextensivelyexploitedaseukaryoticproteinexpressionvectors.Molecularbiologystudieshaveprovidedexcitingdiscoveriesonvirus–hostinter-actions,buttheapplicationofomichigh-throughputtechniquesonthebaculovirus–insectcellsystemhasbeenhamperedbythelackofhostgenomesequencing.Whileabroader,systems-levelanalysisofbiologicalresponsestoinfectionisurgentlyneeded,recentadvancesonproteomicstudieshaveyieldednewinsightsontheimpactofinfectiononthehostcell.Theseworksarereviewedandcriticallyassessedinthelightofcurrentbiologicalknowledgeofthemolecularbiologyofbaculovirusesandinsectcells.
Original languageEnglish
Pages (from-to)ART391
JournalFrontiers in Microbiology
Volume3
Issue numberNA
DOIs
Publication statusPublished - 1 Nov 2012

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