Toward system-level understanding of baculovirus–host cell interactions: from molecular fundamental studies to large-scale proteomics approaches

Nuno Carinhas; Manuel José Teixeira Carrondo; Paula Maria Alves

doi:10.3389/fmicb.2012.00391

Toward system-level understanding of baculovirus–host cell interactions: from molecular fundamental studies to large-scale proteomics approaches

Nuno Carinhas, Manuel José Teixeira Carrondo, Paula Maria Alves

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Baculovirusesareinsectvirusesextensivelyexploitedaseukaryoticproteinexpressionvectors.Molecularbiologystudieshaveprovidedexcitingdiscoveriesonvirus–hostinter-actions,buttheapplicationofomichigh-throughputtechniquesonthebaculovirus–insectcellsystemhasbeenhamperedbythelackofhostgenomesequencing.Whileabroader,systems-levelanalysisofbiologicalresponsestoinfectionisurgentlyneeded,recentadvancesonproteomicstudieshaveyieldednewinsightsontheimpactofinfectiononthehostcell.Theseworksarereviewedandcriticallyassessedinthelightofcurrentbiologicalknowledgeofthemolecularbiologyofbaculovirusesandinsectcells.

Original language	English
Pages (from-to)	ART391
Journal	Frontiers in Microbiology
Volume	3
Issue number	NA
DOIs	https://doi.org/10.3389/fmicb.2012.00391
Publication status	Published - 1 Nov 2012

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title = "Toward system-level understanding of baculovirus–host cell interactions: from molecular fundamental studies to large-scale proteomics approaches",

abstract = "Baculovirusesareinsectvirusesextensivelyexploitedaseukaryoticproteinexpressionvectors.Molecularbiologystudieshaveprovidedexcitingdiscoveriesonvirus–hostinter-actions,buttheapplicationofomichigh-throughputtechniquesonthebaculovirus–insectcellsystemhasbeenhamperedbythelackofhostgenomesequencing.Whileabroader,systems-levelanalysisofbiologicalresponsestoinfectionisurgentlyneeded,recentadvancesonproteomicstudieshaveyieldednewinsightsontheimpactofinfectiononthehostcell.Theseworksarereviewedandcriticallyassessedinthelightofcurrentbiologicalknowledgeofthemolecularbiologyofbaculovirusesandinsectcells.",

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AU - Carinhas, Nuno

AU - Carrondo, Manuel José Teixeira

AU - Alves, Paula Maria

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KW - cytoskeleton

KW - proteomics

KW - stress response

KW - apoptosis

KW - virus–host interactions

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JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

IS - NA

ER -

Toward system-level understanding of baculovirus–host cell interactions: from molecular fundamental studies to large-scale proteomics approaches

Abstract

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