Tocilizumab: is there life beyond anti-TNF blockade?

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9 Citations (Scopus)


P>Anti-TNF-alpha therapy has become the most effective biological treatment for rheumatoid arthritis. Despite having changed the prognosis of the disease establishing new targets for treatment strategy, there are several aspects that still remain unmatched. About 30% of the patients with rheumatoid arthritis have a less than satisfactory response to anti-TNF therapy, which has led the way for the pursuit of new targets and approaches to treatment. IL-6 is one of these alternative targets and data from the more recent clinical trials involving tocilizumab (an anti-IL-6 soluble receptor antibody) suggest advantages in relation to some clinical aspects which are not addressed by anti-TNF-alpha treatment.
Original languageEnglish
Pages (from-to)508-513
Number of pages6
JournalInternational Journal Of Clinical Practice
Issue number4
Publication statusPublished - 2011


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