Tidying-up the plant nuclear space: Domains, functions, and dynamics

Ana Paula Santos, Valérie Gaudin, Iva Mozgová, Frédéric Pontvianne, Daniel Schubert, Ahmet L. Tek, Martina Dvoøáèková, Chang Liu, Paul Fransz, Stefanie Rosa, Sara Farrona

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

Understanding how the packaging of chromatin in the nucleus is regulated and organized to guide complex cellular and developmental programmes, as well as responses to environmental cues is a major question in biology. Technological advances have allowed remarkable progress within this field over the last years. However, we still know very little about how the 3D genome organization within the cell nucleus contributes to the regulation of gene expression. The nuclear space is compartmentalized in several domains such as the nucleolus, chromocentres, telomeres, protein bodies, and the nuclear periphery without the presence of a membrane around these domains. The role of these domains and their possible impact on nuclear activities is currently under intense investigation. In this review, we discuss new data from research in plants that clarify functional links between the organization of different nuclear domains and plant genome function with an emphasis on the potential of this organization for gene regulation.

Original languageEnglish
Pages (from-to)5160-5178
Number of pages19
JournalJournal Of Experimental Botany
Volume71
Issue number17
DOIs
Publication statusPublished - 17 Aug 2020

Keywords

  • 3D chromatin organization
  • Chromocentres
  • Gene expression
  • Liquid-liquid phase separation (LLPS)
  • Nuclear bodies
  • Nuclear domains
  • Nuclear periphery
  • Nucleolus
  • Telomeres
  • Topologically associated domains (TADs)

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