Tick Vaccines and Concealed versus Exposed Antigens

Research output: Contribution to journalComment/debatepeer-review

3 Citations (Scopus)
20 Downloads (Pure)

Abstract

Anti-tick vaccines development mainly depends on the identification of suitable antigens, which ideally should have different features. These should be key molecules in tick biology, encoded by a single gene, expressed across life stages and tick tissues, capable of inducing B and T cells to promote an immunological response without allergenic, hemolytic, and toxic effects; and should not be homologous to the mammalian host. The discussion regarding this subject and the usefulness of “exposed” and “concealed” antigens was effectively explored in the publication by Nuttall et al. (2006). The present commentary intends to debate the relevance of such study in the field of tick immunological control.

Original languageEnglish
Article number374
Number of pages10
JournalPathogens
Volume12
Issue number3
DOIs
Publication statusPublished - Mar 2023

Keywords

  • tick control
  • vaccine
  • “concealed” antigen
  • “exposed” antigen

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