Thioridazine cures extensively drug-resistant tuberculosis (XDR-TB) and the need for global trials is now!

Leonard Amaral, Martin J. Boeree, Stephen H. Gillespie, Zarir F. Udwadia, Dick van Soolingen

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Thioridazine (TDZ) has been shown to have in vitro activity against multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis, to promote the killing of intracellular MDR and XDR strains and to cure the mouse of antibiotic-susceptible and -resistant pulmonary tuberculosis (TB) infections. Recently, TDZ was used to cure 10 of 12 XDR-TB patients in Buenos Aires, Argentina. At the time of writing, it is being used for the therapy of non-antibiotic-responsive terminal XDR-TB patients in Mumbai, India, on the basis of compassionate therapy and although it is too early to determine a cure, the patients have improved appetite, weight gain, are afebrile and free of night sweats, and their radiological picture shows great improvement. Because XDR-TB is essentially a terminal disease in many areas of the world and no new effective agents have yet to yield successful clinical trials, global clinical trials for the therapy of XDR-TB are urgently required.
Original languageEnglish
Pages (from-to)524-6
JournalInternational Journal Of Antimicrobial Agents
Volume35
Issue number6
DOIs
Publication statusPublished - 1 Jan 2010

UN Sustainable Development Goals (SDGs)

  • SDG 3 - Good Health and Well-Being

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