Thioridazine: alternative and potentially effective therapy of the XDRTB patient

L. Amaral; M. Martins; M. Viveiros

doi:10.2174/157018011794183860

Thioridazine: alternative and potentially effective therapy of the XDRTB patient

L. Amaral, M. Martins, M. Viveiros

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Pulmonary tuberculosis infections caused by multi-drug resistant Mycobacterium tuberculosis has progressed to extensively drug resistant status (XDR-TB). XDR-TB is very difficult to treat successfully and results in high mortality. Globally, XDR-TB is now a major threat, especially to India and countries that were once part of the Soviet Union.

There is a potential alternative to current ineffective therapy that is solidly supported by in vitro, ex vivo and in vivo studies. It has reported successful therapies in 10 out of 12 non-responsive XDR-TB patients. That therapy is thioridazine, and it is the purpose of this mini-review to provide the rationale for thioridazine therapy, especially for compassionate reasons, when all other therapies have failed, depicting on extremely poor prognosis.

Original language	English
Pages (from-to)	130-132
Number of pages	3
Journal	Letters In Drug Design & Discovery
Volume	8
Issue number	2
DOIs	https://doi.org/10.2174/157018011794183860
Publication status	Published - Feb 2011

Keywords

Macrophage activation, MDR-TB
MDR-TB
Phenothiazines
Therapy
Thioridazine
XDR-TB
Pulmonary tuberculosis infections
Mycobacterium tuberculosis
Thioridazine therapy
Mycobacteria bind
Pneumocyte II
Isoniazid
Rifampicin
Kanamycin
Amikacin
Capreomycin
Psychosis
Syphilis
Narcotize
Colorless neuroleptic chlorpromazine
Neuroleptic thioridazine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/157018011794183860

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title = "Thioridazine: alternative and potentially effective therapy of the XDRTB patient",

abstract = "Pulmonary tuberculosis infections caused by multi-drug resistant Mycobacterium tuberculosis has progressed to extensively drug resistant status (XDR-TB). XDR-TB is very difficult to treat successfully and results in high mortality. Globally, XDR-TB is now a major threat, especially to India and countries that were once part of the Soviet Union.There is a potential alternative to current ineffective therapy that is solidly supported by in vitro, ex vivo and in vivo studies. It has reported successful therapies in 10 out of 12 non-responsive XDR-TB patients. That therapy is thioridazine, and it is the purpose of this mini-review to provide the rationale for thioridazine therapy, especially for compassionate reasons, when all other therapies have failed, depicting on extremely poor prognosis.",

keywords = "Macrophage activation, MDR-TB, MDR-TB, Phenothiazines, Therapy, Thioridazine, XDR-TB, Pulmonary tuberculosis infections, Mycobacterium tuberculosis, Thioridazine therapy, Mycobacteria bind, Pneumocyte II, Isoniazid, Rifampicin, Kanamycin, Amikacin, Capreomycin, Psychosis, Syphilis, Narcotize, Colorless neuroleptic chlorpromazine, Neuroleptic thioridazine",

author = "L. Amaral and M. Martins and M. Viveiros",

year = "2011",

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doi = "10.2174/157018011794183860",

language = "English",

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AU - Amaral, L.

AU - Martins, M.

AU - Viveiros, M.

PY - 2011/2

Y1 - 2011/2

N2 - Pulmonary tuberculosis infections caused by multi-drug resistant Mycobacterium tuberculosis has progressed to extensively drug resistant status (XDR-TB). XDR-TB is very difficult to treat successfully and results in high mortality. Globally, XDR-TB is now a major threat, especially to India and countries that were once part of the Soviet Union.There is a potential alternative to current ineffective therapy that is solidly supported by in vitro, ex vivo and in vivo studies. It has reported successful therapies in 10 out of 12 non-responsive XDR-TB patients. That therapy is thioridazine, and it is the purpose of this mini-review to provide the rationale for thioridazine therapy, especially for compassionate reasons, when all other therapies have failed, depicting on extremely poor prognosis.

AB - Pulmonary tuberculosis infections caused by multi-drug resistant Mycobacterium tuberculosis has progressed to extensively drug resistant status (XDR-TB). XDR-TB is very difficult to treat successfully and results in high mortality. Globally, XDR-TB is now a major threat, especially to India and countries that were once part of the Soviet Union.There is a potential alternative to current ineffective therapy that is solidly supported by in vitro, ex vivo and in vivo studies. It has reported successful therapies in 10 out of 12 non-responsive XDR-TB patients. That therapy is thioridazine, and it is the purpose of this mini-review to provide the rationale for thioridazine therapy, especially for compassionate reasons, when all other therapies have failed, depicting on extremely poor prognosis.

KW - Macrophage activation, MDR-TB

KW - MDR-TB

KW - Phenothiazines

KW - Therapy

KW - Thioridazine

KW - XDR-TB

KW - Pulmonary tuberculosis infections

KW - Mycobacterium tuberculosis

KW - Thioridazine therapy

KW - Mycobacteria bind

KW - Pneumocyte II

KW - Isoniazid

KW - Rifampicin

KW - Kanamycin

KW - Amikacin

KW - Capreomycin

KW - Psychosis

KW - Syphilis

KW - Narcotize

KW - Colorless neuroleptic chlorpromazine

KW - Neuroleptic thioridazine

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U2 - 10.2174/157018011794183860

DO - 10.2174/157018011794183860

M3 - Article

SN - 1570-1808

VL - 8

SP - 130

EP - 132

JO - Letters In Drug Design & Discovery

JF - Letters In Drug Design & Discovery

IS - 2

ER -

Thioridazine: alternative and potentially effective therapy of the XDRTB patient

Abstract

Keywords

UN SDGs

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