Thermodynamics and fluorescence emission studies on potential molecular chemosensors for ATP recognition in aqueous solution

M. Teresa Albelda, M. Alexandra Bernardo, Enrique Garcia-España, M. Luz Godino-Salido, Santiago V. Luis, Maria João Melo, Fernando Pina, Conxa Soriano

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)

Abstract

The interaction of the open-chain polyamine N-(3-aminopropyl)-N′-[3-(anthrylmethyl)aminopropyl]ethane-1,2-diamine (L) with the relevant anionic forms of adenosine 5′-triphosphate (ATP), adenosme 5′-diphosphate (ADP) and adenosine 5′-monophosphate (AMP) is described. Unambiguous criteria for defining thermodynamic selectivity based on the use of effective stability constants are presented. The interaction of L and several other topologically similar polyammonium receptors with ATP has been shown to occur through electrostatic and π-stacking intermolecular forces The π-stacking binding mode is modulated by the protonation degree of ATP as indicated by fluorescence emission titrations. Evidence for the use of these receptors as ATP luminescent chemosensors is advanced.

Original languageEnglish
Pages (from-to)2545-2549
Number of pages5
JournalJournal of the Chemical Society. Perkin Transactions 2
Issue number11
DOIs
Publication statusPublished - 1 Jan 1999

Fingerprint

Dive into the research topics of 'Thermodynamics and fluorescence emission studies on potential molecular chemosensors for ATP recognition in aqueous solution'. Together they form a unique fingerprint.

Cite this