TY - JOUR
T1 - Thermal and magnetic properties of iron oxide colloids
T2 - influence of surfactants
AU - Soares, P
AU - Lochte, Frederik
AU - Echeverria, Maria del Coro
AU - Pereira, Laura C. J.
AU - Coutinho, Joana T.
AU - Ferreira, Isabel M. M.
AU - Novo, Carlos M. M.
AU - Borges, Joao P. M. R.
N1 - Sem PDF.
This work is funded by FEDER funds through the COMPETE 2020 Programme and National Funds through FCT-Portuguese Foundation for Science and Technology under the project UID/CTM/50025/2013. PIPS and JTC acknowledge FCT for PhD grants, SFRH/BD/81711/2011 and SFRH/BD/84628/2012, respectively. The authors wish to thank Dr Cesar Laia for the dynamic light scattering measurements.
PY - 2015/10/23
Y1 - 2015/10/23
N2 - Iron oxide nanoparticles (NPs) have been extensively studied in the last few decades for several biomedical applications such as magnetic resonance imaging, magnetic drug delivery and hyperthermia. Hyperthermia is a technique used for cancer treatment which consists in inducing a temperature of about 41-45 degrees C in cancerous cells through magnetic NPs and an external magnetic field. Chemical precipitation was used to produce iron oxide NPs 9 nm in size coated with oleic acid and trisodium citrate. The influence of both stabilizers on the heating ability and in vitro cytotoxicity of the produced iron oxide NPs was assessed. Physicochemical characterization of the samples confirmed that the used surfactants do not change the particles' average size and that the presence of the surfactants has a strong effect on both the magnetic properties and the heating ability. The heating ability of Fe3O4 NPs shows a proportional increase with the increase of iron concentration, although when coated with trisodium citrate or oleic acid the heating ability decreases. Cytotoxicity assays demonstrated that both pristine and trisodium citrate Fe3O4 samples do not reduce cell viability. However, oleic acid Fe3O4 strongly reduces cell viability, more drastically in the SaOs-2 cell line. The produced iron oxide NPs are suitable for cancer hyperthermia treatment and the use of a surfactant brings great advantages concerning the dispersion of NPs, also allowing better control of the hyperthermia temperature.
AB - Iron oxide nanoparticles (NPs) have been extensively studied in the last few decades for several biomedical applications such as magnetic resonance imaging, magnetic drug delivery and hyperthermia. Hyperthermia is a technique used for cancer treatment which consists in inducing a temperature of about 41-45 degrees C in cancerous cells through magnetic NPs and an external magnetic field. Chemical precipitation was used to produce iron oxide NPs 9 nm in size coated with oleic acid and trisodium citrate. The influence of both stabilizers on the heating ability and in vitro cytotoxicity of the produced iron oxide NPs was assessed. Physicochemical characterization of the samples confirmed that the used surfactants do not change the particles' average size and that the presence of the surfactants has a strong effect on both the magnetic properties and the heating ability. The heating ability of Fe3O4 NPs shows a proportional increase with the increase of iron concentration, although when coated with trisodium citrate or oleic acid the heating ability decreases. Cytotoxicity assays demonstrated that both pristine and trisodium citrate Fe3O4 samples do not reduce cell viability. However, oleic acid Fe3O4 strongly reduces cell viability, more drastically in the SaOs-2 cell line. The produced iron oxide NPs are suitable for cancer hyperthermia treatment and the use of a surfactant brings great advantages concerning the dispersion of NPs, also allowing better control of the hyperthermia temperature.
KW - hyperthermia
KW - iron oxide nanoparticles
KW - magnetic characterization
UR - http://www.scopus.com/inward/record.url?scp=84947577938&partnerID=8YFLogxK
U2 - 10.1088/0957-4484/26/42/425704
DO - 10.1088/0957-4484/26/42/425704
M3 - Article
C2 - 26421876
AN - SCOPUS:84947577938
SN - 0957-4484
VL - 26
JO - Nanotechnology
JF - Nanotechnology
IS - 42
M1 - 425704
ER -
