The sensory system of the esophagus-what do we know?

Christina Brock, Hans Gregersen, C. Prakash Gyawali, Christian Lottrup, Manuele Furnari, Edoardo Savarino, Luís Novais, Jens Brondum Frokjaer, Serhat Bor, Asbjorn Mohr Drewes

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

The nervous innervation and complex mechanical function of the esophagus make sensory evaluation difficult. However, during the last decades, several new techniques have made it possible to gain insight into pain processing of nociceptive signals. The current review highlights the sensory innervation and possibilities for quantitative sensory testing, the mechanosensory properties, the potential of high-resolution manometry and imaging, and the sensory system in special conditions, such as Barrett's esophagus. It is mandatory to understand the complex pathophysiology of the esophagus to enhance our understanding of esophageal disorders, but it also increases the complexity of future experimental and clinical studies. The new methods, as outlined in the current review, provide the possibility for researchers to enhance the quality of interdisciplinary research and to gain more knowledge about sensory symptoms and treatment possibilities.

Original languageEnglish
Title of host publication13TH OESO WORLD CONFERENCE: THE ESOPHAGIOME I
EditorsR Giuli, H Gregersen
PublisherBLACKWELL SCIENCE PUBL
Pages91-103
Number of pages13
DOIs
Publication statusPublished - 2016
Event13th OESO World Conference - , Monaco
Duration: 31 Aug 20153 Sep 2015

Publication series

NameAnnals of the New York Academy of Sciences
PublisherBLACKWELL SCIENCE PUBL
Volume1380
ISSN (Print)0077-8923

Conference

Conference13th OESO World Conference
CountryMonaco
Period31/08/153/09/15

Keywords

  • esophagus
  • pain
  • neurophysiology
  • imaging
  • brain
  • NONEROSIVE REFLUX DISEASE
  • ENTERIC NERVOUS-SYSTEM
  • FUNCTIONAL CHEST-PAIN
  • GASTROESOPHAGEAL-REFLUX
  • BARRETTS-ESOPHAGUS
  • ACID SENSITIVITY
  • SMOOTH-MUSCLE
  • GASTROINTESTINAL-TRACT
  • CHRONIC-PANCREATITIS
  • DISORDERS

Cite this

Brock, C., Gregersen, H., Gyawali, C. P., Lottrup, C., Furnari, M., Savarino, E., Novais, L., Frokjaer, J. B., Bor, S., & Drewes, A. M. (2016). The sensory system of the esophagus-what do we know? In R. Giuli, & H. Gregersen (Eds.), 13TH OESO WORLD CONFERENCE: THE ESOPHAGIOME I (pp. 91-103). (Annals of the New York Academy of Sciences; Vol. 1380). BLACKWELL SCIENCE PUBL. https://doi.org/10.1111/nyas.13205