The role of the retinal pigment epithelium and Müller cells secretome in neovascular retinal pathologies

Rute S Araújo; Daniela F Santos; Gabriela A Silva

doi:10.1016/j.biochi.2018.06.019

The role of the retinal pigment epithelium and Müller cells secretome in neovascular retinal pathologies

Rute S Araújo, Daniela F Santos, Gabriela A Silva

Research output: Contribution to journal › Short survey › peer-review

24 Citations (Scopus)

Abstract

Secreted trophic factors are key to maintain the structural and functional integrity of the retina, as they regulate cellular pathways responsible for survival, function, and response to injury. Nevertheless, these same factors can also be involved in retinal pathologies, as a consequence of the impairment of the secretory function of cells. The cells considered as major contributors to the retinal secretome are the retinal pigmented epithelium (RPE) and Müller cells. Their role in the pathophysiology of the most common neovascular pathologies in the retina - Age-related Macular Degeneration (AMD), Diabetic Retinopathy (DR), and Retinopathy of Prematurity (ROP) - is highlighted in this short review, together with current trophic factor-based therapies, which are mainly focused on controlling inflammation, cell survival, and angiogenesis.

Original language	English
Pages (from-to)	104-108
Number of pages	5
Journal	Biochimie
Volume	155
Issue number	SI
Early online date	27 Jun 2018
DOIs	https://doi.org/10.1016/j.biochi.2018.06.019
Publication status	Published - Dec 2018

Keywords

Retina
Retinal pigment epithelium (RPE)
Muller cells
Secretome
Neovascularization

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.biochi.2018.06.019

Cite this

@article{09deff4961da4a62abf5813824b88176,

title = "The role of the retinal pigment epithelium and M{\"u}ller cells secretome in neovascular retinal pathologies",

abstract = "Secreted trophic factors are key to maintain the structural and functional integrity of the retina, as they regulate cellular pathways responsible for survival, function, and response to injury. Nevertheless, these same factors can also be involved in retinal pathologies, as a consequence of the impairment of the secretory function of cells. The cells considered as major contributors to the retinal secretome are the retinal pigmented epithelium (RPE) and M{\"u}ller cells. Their role in the pathophysiology of the most common neovascular pathologies in the retina - Age-related Macular Degeneration (AMD), Diabetic Retinopathy (DR), and Retinopathy of Prematurity (ROP) - is highlighted in this short review, together with current trophic factor-based therapies, which are mainly focused on controlling inflammation, cell survival, and angiogenesis.",

keywords = "Retina, Retinal pigment epithelium (RPE), Muller cells, Secretome, Neovascularization",

author = "Ara{\'u}jo, {Rute S} and Santos, {Daniela F} and Silva, {Gabriela A}",

note = "Copyright {\textcopyright} 2018. Published by Elsevier B.V.",

year = "2018",

month = dec,

doi = "10.1016/j.biochi.2018.06.019",

language = "English",

volume = "155",

pages = "104--108",

journal = "Biochimie",

issn = "0300-9084",

publisher = "Elsevier Science B.V., Amsterdam.",

number = "SI",

}

TY - JOUR

T1 - The role of the retinal pigment epithelium and Müller cells secretome in neovascular retinal pathologies

AU - Araújo, Rute S

AU - Santos, Daniela F

AU - Silva, Gabriela A

PY - 2018/12

Y1 - 2018/12

N2 - Secreted trophic factors are key to maintain the structural and functional integrity of the retina, as they regulate cellular pathways responsible for survival, function, and response to injury. Nevertheless, these same factors can also be involved in retinal pathologies, as a consequence of the impairment of the secretory function of cells. The cells considered as major contributors to the retinal secretome are the retinal pigmented epithelium (RPE) and Müller cells. Their role in the pathophysiology of the most common neovascular pathologies in the retina - Age-related Macular Degeneration (AMD), Diabetic Retinopathy (DR), and Retinopathy of Prematurity (ROP) - is highlighted in this short review, together with current trophic factor-based therapies, which are mainly focused on controlling inflammation, cell survival, and angiogenesis.

AB - Secreted trophic factors are key to maintain the structural and functional integrity of the retina, as they regulate cellular pathways responsible for survival, function, and response to injury. Nevertheless, these same factors can also be involved in retinal pathologies, as a consequence of the impairment of the secretory function of cells. The cells considered as major contributors to the retinal secretome are the retinal pigmented epithelium (RPE) and Müller cells. Their role in the pathophysiology of the most common neovascular pathologies in the retina - Age-related Macular Degeneration (AMD), Diabetic Retinopathy (DR), and Retinopathy of Prematurity (ROP) - is highlighted in this short review, together with current trophic factor-based therapies, which are mainly focused on controlling inflammation, cell survival, and angiogenesis.

KW - Retina

KW - Retinal pigment epithelium (RPE)

KW - Muller cells

KW - Secretome

KW - Neovascularization

U2 - 10.1016/j.biochi.2018.06.019

DO - 10.1016/j.biochi.2018.06.019

M3 - Short survey

C2 - 29960032

SN - 0300-9084

VL - 155

SP - 104

EP - 108

JO - Biochimie

JF - Biochimie

IS - SI

ER -

The role of the retinal pigment epithelium and Müller cells secretome in neovascular retinal pathologies

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this