The role of the retinal pigment epithelium and Müller cells secretome in neovascular retinal pathologies

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Secreted trophic factors are key to maintain the structural and functional integrity of the retina, as they regulate cellular pathways responsible for survival, function, and response to injury. Nevertheless, these same factors can also be involved in retinal pathologies, as a consequence of the impairment of the secretory function of cells. The cells considered as major contributors to the retinal secretome are the retinal pigmented epithelium (RPE) and Müller cells. Their role in the pathophysiology of the most common neovascular pathologies in the retina - Age-related Macular Degeneration (AMD), Diabetic Retinopathy (DR), and Retinopathy of Prematurity (ROP) - is highlighted in this short review, together with current trophic factor-based therapies, which are mainly focused on controlling inflammation, cell survival, and angiogenesis.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalBiochimie
Volume155
Issue numberSI
Early online date27 Jun 2018
DOIs
Publication statusPublished - Dec 2018

Keywords

  • Retina
  • Retinal pigment epithelium (RPE)
  • Muller cells
  • Secretome
  • Neovascularization

Fingerprint Dive into the research topics of 'The role of the retinal pigment epithelium and Müller cells secretome in neovascular retinal pathologies'. Together they form a unique fingerprint.

Cite this