The role of the retinal pigment epithelium and Müller cells secretome in neovascular retinal pathologies

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2 Citations (Scopus)

Abstract

Secreted trophic factors are key to maintain the structural and functional integrity of the retina, as they regulate cellular pathways responsible for survival, function, and response to injury. Nevertheless, these same factors can also be involved in retinal pathologies, as a consequence of the impairment of the secretory function of cells. The cells considered as major contributors to the retinal secretome are the retinal pigmented epithelium (RPE) and Müller cells. Their role in the pathophysiology of the most common neovascular pathologies in the retina - Age-related Macular Degeneration (AMD), Diabetic Retinopathy (DR), and Retinopathy of Prematurity (ROP) - is highlighted in this short review, together with current trophic factor-based therapies, which are mainly focused on controlling inflammation, cell survival, and angiogenesis.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalBiochimie
Volume155
Issue numberSI
Early online date27 Jun 2018
DOIs
Publication statusPublished - Dec 2018

Fingerprint

Retinal Pigments
Retinal Pigment Epithelium
Pathology
Retina
Retinopathy of Prematurity
Cells
Macular Degeneration
Diabetic Retinopathy
Cell Survival
Epithelium
Inflammation
Wounds and Injuries
Therapeutics

Keywords

  • Retina
  • Retinal pigment epithelium (RPE)
  • Muller cells
  • Secretome
  • Neovascularization

Cite this

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title = "The role of the retinal pigment epithelium and M{\"u}ller cells secretome in neovascular retinal pathologies",
abstract = "Secreted trophic factors are key to maintain the structural and functional integrity of the retina, as they regulate cellular pathways responsible for survival, function, and response to injury. Nevertheless, these same factors can also be involved in retinal pathologies, as a consequence of the impairment of the secretory function of cells. The cells considered as major contributors to the retinal secretome are the retinal pigmented epithelium (RPE) and M{\"u}ller cells. Their role in the pathophysiology of the most common neovascular pathologies in the retina - Age-related Macular Degeneration (AMD), Diabetic Retinopathy (DR), and Retinopathy of Prematurity (ROP) - is highlighted in this short review, together with current trophic factor-based therapies, which are mainly focused on controlling inflammation, cell survival, and angiogenesis.",
keywords = "Retina, Retinal pigment epithelium (RPE), Muller cells, Secretome, Neovascularization",
author = "Ara{\'u}jo, {Rute S} and Santos, {Daniela F} and Silva, {Gabriela A}",
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year = "2018",
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T1 - The role of the retinal pigment epithelium and Müller cells secretome in neovascular retinal pathologies

AU - Araújo, Rute S

AU - Santos, Daniela F

AU - Silva, Gabriela A

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PY - 2018/12

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N2 - Secreted trophic factors are key to maintain the structural and functional integrity of the retina, as they regulate cellular pathways responsible for survival, function, and response to injury. Nevertheless, these same factors can also be involved in retinal pathologies, as a consequence of the impairment of the secretory function of cells. The cells considered as major contributors to the retinal secretome are the retinal pigmented epithelium (RPE) and Müller cells. Their role in the pathophysiology of the most common neovascular pathologies in the retina - Age-related Macular Degeneration (AMD), Diabetic Retinopathy (DR), and Retinopathy of Prematurity (ROP) - is highlighted in this short review, together with current trophic factor-based therapies, which are mainly focused on controlling inflammation, cell survival, and angiogenesis.

AB - Secreted trophic factors are key to maintain the structural and functional integrity of the retina, as they regulate cellular pathways responsible for survival, function, and response to injury. Nevertheless, these same factors can also be involved in retinal pathologies, as a consequence of the impairment of the secretory function of cells. The cells considered as major contributors to the retinal secretome are the retinal pigmented epithelium (RPE) and Müller cells. Their role in the pathophysiology of the most common neovascular pathologies in the retina - Age-related Macular Degeneration (AMD), Diabetic Retinopathy (DR), and Retinopathy of Prematurity (ROP) - is highlighted in this short review, together with current trophic factor-based therapies, which are mainly focused on controlling inflammation, cell survival, and angiogenesis.

KW - Retina

KW - Retinal pigment epithelium (RPE)

KW - Muller cells

KW - Secretome

KW - Neovascularization

U2 - 10.1016/j.biochi.2018.06.019

DO - 10.1016/j.biochi.2018.06.019

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