The role of RNases in the regulation of small RNAs

Margarida Saramago; Cátia Bárria; Ricardo F. dos Santos; Inês J. Silva; Vânia Pobre; Susana Domingues; Jose Eduardo Andrade; Sandra C. Viegas; Cecília M. Arraiano

doi:10.1016/j.mib.2014.02.009

The role of RNases in the regulation of small RNAs

Margarida Saramago, Cátia Bárria, Ricardo F. dos Santos, Inês J. Silva, Vânia Pobre, Susana Domingues, Jose Eduardo Andrade, Sandra C. Viegas, Cecília M. Arraiano

Instituto de Tecnologia Química e Biológica António Xavier (ITQB)

Research output: Contribution to journal › Review article › peer-review

87 Citations (Scopus)

Abstract

Ribonucleases (RNases) are key factors in the control of biological processes, since they modulate the processing, degradation and quality control of RNAs. This review gives many illustrative examples of the role of RNases in the regulation of small RNAs (sRNAs). RNase E and PNPase have been shown to degrade the free pool of sRNAs. RNase E can also be recruited to cleave mRNAs when they are interacting with sRNAs. RNase III cleaves double-stranded structures, and can cut both the sRNA and its RNA target when they are hybridized. Overall, ribonucleases act as conductors in the control of sRNAs. Therefore, it is very important to further understand their role in the post-transcriptional control of gene expression.

Original language	English
Pages (from-to)	105-115
Number of pages	11
Journal	Current Opinion in Microbiology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1016/j.mib.2014.02.009
Publication status	Published - 2014

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abstract = "Ribonucleases (RNases) are key factors in the control of biological processes, since they modulate the processing, degradation and quality control of RNAs. This review gives many illustrative examples of the role of RNases in the regulation of small RNAs (sRNAs). RNase E and PNPase have been shown to degrade the free pool of sRNAs. RNase E can also be recruited to cleave mRNAs when they are interacting with sRNAs. RNase III cleaves double-stranded structures, and can cut both the sRNA and its RNA target when they are hybridized. Overall, ribonucleases act as conductors in the control of sRNAs. Therefore, it is very important to further understand their role in the post-transcriptional control of gene expression.",

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AU - Saramago, Margarida

AU - Bárria, Cátia

AU - dos Santos, Ricardo F.

AU - Silva, Inês J.

AU - Pobre, Vânia

AU - Domingues, Susana

AU - Andrade, Jose Eduardo

AU - Viegas, Sandra C.

AU - Arraiano, Cecília M.

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AB - Ribonucleases (RNases) are key factors in the control of biological processes, since they modulate the processing, degradation and quality control of RNAs. This review gives many illustrative examples of the role of RNases in the regulation of small RNAs (sRNAs). RNase E and PNPase have been shown to degrade the free pool of sRNAs. RNase E can also be recruited to cleave mRNAs when they are interacting with sRNAs. RNase III cleaves double-stranded structures, and can cut both the sRNA and its RNA target when they are hybridized. Overall, ribonucleases act as conductors in the control of sRNAs. Therefore, it is very important to further understand their role in the post-transcriptional control of gene expression.

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The role of RNases in the regulation of small RNAs

Abstract

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