The role of RNase R in trans-translation and ribosomal quality control

Susana Domingues, Ricardo N. Moreira, Jose Eduardo Andrade, Ricardo F. Dos Santos, Cátia Bárria, Sandra C. Viegas, Cecília M. Arraiano

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Abstract Gene expression not only depends on the rate of transcription but is also largely controlled at the post-transcriptional level. Translation rate and mRNA decay greatly influence the final protein levels. Surveillance mechanisms are essential to ensure the quality of the RNA and proteins produced. Trans-translation is one of the most important systems in the quality control of bacterial translation. This process guarantees the destruction of abnormal proteins and also leads to degradation of the respective defective RNAs through the action of Ribonuclease R (RNase R). This exoribonuclease hydrolyzes RNAs starting from their 3′ end. Besides its involvement in trans-translation, RNase R also participates in the quality control of rRNA molecules involved in ribosomal biogenesis. RNase R is thus emerging as a key factor in ensuring translation accuracy. This review focuses on issues related to the quality control of translation, with special emphasis on the role of RNase R.

Original languageEnglish
Article number4615
Pages (from-to)113-118
Number of pages6
Publication statusPublished - 15 Sep 2015


  • Nonstop
  • Ribosome
  • RNA degradation
  • SmpB
  • SsrA
  • tmRNA


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