TY - JOUR
T1 - The role of low-energy electron interactions in cis-pt(Co)2 br2 fragmentation
AU - Cipriani, Maicol
AU - Svavarsson, Styrmir
AU - da Silva, Filipe Ferreira
AU - Lu, Hang
AU - McElwee-White, Lisa
AU - Ingólfsson, Oddur
N1 - Funding Information:
Funding: This project was conducted within the framework of ELENA, a Horizon 2020 research and innovation program under Marie Sklodowska-Curie Innovative Training Network, under the grant agreement No. 722149. M.C. and O.I. acknowledge support from the Icelandic Center of Research (RANNIS), grant no. 13049305(1−3). M.C. acknowledges a doctoral grant from the University of Iceland Research Fund. H.L. and L.M.-W. thank the National Science Foundation for support under grants CHE-1607547 and CHE-1904802. F.F.d.S. acknowledges the Portuguese National Funding Agency for Science Research and Technology (FCT-MCTES), through the research grants PTDC/FIS-AQM/31215/2017 and UIDB/00068/2020 (CEFITEC).
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/8/20
Y1 - 2021/8/20
N2 - Platinum coordination complexes have found wide applications as chemotherapeutic anticancer drugs in synchronous combination with radiation (chemoradiation) as well as precursors in focused electron beam induced deposition (FEBID) for nano-scale fabrication. In both applications, low-energy electrons (LEE) play an important role with regard to the fragmentation pathways. In the former case, the high-energy radiation applied creates an abundance of reactive photo-and secondary electrons that determine the reaction paths of the respective radiation sensitizers. In the latter case, low-energy secondary electrons determine the deposition chemistry. In this contribution, we present a combined experimental and theoretical study on the role of LEE interactions in the fragmentation of the Pt(II) coordination compound cis-PtBr2 (CO)2. We discuss our results in conjunction with the widely used cancer therapeutic Pt(II) coordination compound cis-Pt(NH3)2 Cl2 (cisplatin) and the carbonyl analog Pt(CO)2 Cl2, and we show that efficient CO loss through dissociative electron attachment dominates the reactivity of these carbonyl complexes with low-energy electrons, while halogen loss through DEA dominates the reactivity of cis-Pt(NH3)2 Cl2.
AB - Platinum coordination complexes have found wide applications as chemotherapeutic anticancer drugs in synchronous combination with radiation (chemoradiation) as well as precursors in focused electron beam induced deposition (FEBID) for nano-scale fabrication. In both applications, low-energy electrons (LEE) play an important role with regard to the fragmentation pathways. In the former case, the high-energy radiation applied creates an abundance of reactive photo-and secondary electrons that determine the reaction paths of the respective radiation sensitizers. In the latter case, low-energy secondary electrons determine the deposition chemistry. In this contribution, we present a combined experimental and theoretical study on the role of LEE interactions in the fragmentation of the Pt(II) coordination compound cis-PtBr2 (CO)2. We discuss our results in conjunction with the widely used cancer therapeutic Pt(II) coordination compound cis-Pt(NH3)2 Cl2 (cisplatin) and the carbonyl analog Pt(CO)2 Cl2, and we show that efficient CO loss through dissociative electron attachment dominates the reactivity of these carbonyl complexes with low-energy electrons, while halogen loss through DEA dominates the reactivity of cis-Pt(NH3)2 Cl2.
KW - Anticancer drugs
KW - Cisplatin
KW - Dissociative electron attachment
KW - Dissociative ionization
KW - Focused electron beam induced deposition
KW - Low-energy electrons
KW - Platinum (II) halo-carbonyl complexes
UR - http://www.scopus.com/inward/record.url?scp=85113211524&partnerID=8YFLogxK
U2 - 10.3390/ijms22168984
DO - 10.3390/ijms22168984
M3 - Article
C2 - 34445690
AN - SCOPUS:85113211524
VL - 22
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1422-0067
IS - 16
M1 - 8984
ER -
