The role of endoribonucleases in the regulation of RNase R

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

RNase R is an important exoribonuclease involved in the maturation and degradation of RNA. RNase R is co-transcribed with other genes in the same operon. In this report, we show that under physiological conditions maturation of these co-transcripts and the levels of RNase R are mainly dependent on the endoribonuclease RNase E. The presence of the full-length RNase E is necessary for the decay of intermediary products that arise from the maturation of transcripts from the rnr operon. RNase G and RNase III do not seem to have a primary role in the processing of the rnr transcripts. However, the accumulation of intermediary transcripts in an rng mutant suggests that RNase G may act in the degradation of the transcripts already cleaved by RNase E. These results demonstrated that other ribonucleases can act as an additional level of regulation in the control of the expression of RNase R.

Original languageEnglish
Pages (from-to)731-737
Number of pages7
JournalBiochemical And Biophysical Research Communications
Volume343
Issue number3
DOIs
Publication statusPublished - 12 May 2006

Keywords

  • Degradosome
  • Post-transcriptional regulation
  • ribonuclease
  • RNA degradation
  • RNase E
  • RNase G
  • RNase R

Fingerprint

Dive into the research topics of 'The role of endoribonucleases in the regulation of RNase R'. Together they form a unique fingerprint.

Cite this