TY - JOUR
T1 - The Role of Bone Biopsy in the Management of CKD-MBD
AU - Ferreira, Ana Carina
AU - Cohen-Solal, Martine
AU - D'Haese, Patrick C
AU - Ferreira, Aníbal
PY - 2021/3/26
Y1 - 2021/3/26
N2 - A bone biopsy is still considered the gold standard for diagnosis of renal osteodystrophy. It allows to measure both static and dynamic parameters of bone remodeling and is the only method able to evaluate mineralization and allows analysis of both cortical and trabecular bone. Although bone volume can be measured indirectly by dual-energy X-ray absorptiometry, mineralization defects, bone metal deposits, cellular number/activity, and even turnover abnormalities are difficult to determine by techniques other than qualitative bone histomorphometry. In this review, we evaluate the role of bone biopsy in the clinical practice.
AB - A bone biopsy is still considered the gold standard for diagnosis of renal osteodystrophy. It allows to measure both static and dynamic parameters of bone remodeling and is the only method able to evaluate mineralization and allows analysis of both cortical and trabecular bone. Although bone volume can be measured indirectly by dual-energy X-ray absorptiometry, mineralization defects, bone metal deposits, cellular number/activity, and even turnover abnormalities are difficult to determine by techniques other than qualitative bone histomorphometry. In this review, we evaluate the role of bone biopsy in the clinical practice.
U2 - 10.1007/s00223-021-00838-z
DO - 10.1007/s00223-021-00838-z
M3 - Review article
C2 - 33772341
SN - 0171-967X
VL - 108
SP - 528
EP - 538
JO - Calcified Tissue International
JF - Calcified Tissue International
ER -