The RNase II/RNB family of exoribonucleases: putting the 'Dis' in disease

Filipa Reis; V. Pobre; Inês Silva; Michal Grzegorz Malecki; Cecilia Maria Arraiano

doi:10.1002/wrna.1180

The RNase II/RNB family of exoribonucleases: putting the 'Dis' in disease

Filipa Reis, V. Pobre, Inês Silva, Michal Grzegorz Malecki, Cecilia Maria Arraiano

Instituto de Tecnologia Química e Biológica António Xavier (ITQB)

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Important findings over the last years have shed new light onto the mechanistic details of RNA degradation by members of the RNase II/RNB family of exoribonucleases. Members of this family have been shown to be involved in growth, normal chloroplast biogenesis, mitotic control and cancer. Recently, different publications have linked human orthologs (Dis3 and Dis3L2) to important human diseases. This article describes the structural and biochemical characteristics of members of this family of enzymes, and the physiological implications that relate them with disease. (C) 2013 John Wiley & Sons, Ltd.

Original language	Unknown
Pages (from-to)	607-615
Journal	Wiley Interdisciplinary Reviews. RNA
Volume	4
Issue number	5
DOIs	https://doi.org/10.1002/wrna.1180
Publication status	Published - 1 Jan 2013

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10.1002/wrna.1180

Cite this

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AU - Arraiano, Cecilia Maria

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