The Relevance of Prandial State for Peripheral Insulin-Dependent Glucose Uptake: A Relevância do Estado Prandial para o Aporte Periférico de Glucose por via Insulinodependente

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Insulin action is an essential process for carbohydrates metabolism and for glucose homeostasis in particular. Recently, it has been recognized the vital importance of the prandial state for insulin action, been given a higher relevance to the postprandial state in comparison with the fasted state. In fact, if the pancreas is essential for insulin secretion on one hand, on the other it has been also described an hepatic pathway that contributes to increase insulin action following a meal. Impairment of this hepatic pathway leads to or aggravates insulin resistance, which is in accordance with those reports claiming that the metabolic anomalies observed in the course towards diabetes are first seen in the postprandial state.
In this review it will be provided a brief overview of the major mechanisms of insulin hypoglycemic action in a whole-body perspective, giving particular emphasis to the differences in insulin action between fasted and postprandial states. In particular, it will be discussed how different meal compositions affect postprandial insulin sensitivity and what is the relevance of the hepatic insulin sensitizing substance (HISS)-dependent mechanism for insulin action.
Until now, approaches to the treatment of insulin resistance have been focused almost exclusively on insulin, being based on studies performed in a steady-state (fasted state). It is expected that the present review may serve as a starting point for new approaches and therapeutics for reversion of insulin resistance conditions.
Original languageUnknown
Pages (from-to)96
Number of pages13
JournalRevista Portuguesa de Endocrinologia, Diabetes e Metabolismo
Issue number2
Publication statusPublished - 2011


  • Insulin
  • insulin action
  • insulin receptor
  • insulin signalling pathway
  • glucose uptake

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