The relationship of plasma fatty acid profile and metabolic biomarkers among postmenopausal obese and overweight women

S. Sousa, D. Teixeira, C. Santos, C. Delerue-Matos, C. Calhau, V.F. Domingues

Research output: Contribution to journalArticle

Abstract

Aims: Considering some fatty acids (FA) have anti-inflammatory effects and by other hand obesity and menopause are associated with pro-inflammation, we aimed to investigate the impact of different FA on metabolic parameters among postmenopausal women obese/overweight. Additionally, since after menopause it takes some years for hormonal changes came to an end, the years past menopause (YPM) and the use of hormonal replacement therapy (HRT) were considered. Methods: Blood from 50 Portuguese Caucasian postmenopausal women was collected. FA plasma profile was evaluated by Gas Chromatography–FID (GC-FID). Metabolic parameters analyses were performed in a certified Clinical Analysis Laboratory. Regressions analyses were used to find correlations between FA and metabolic parameters. Results: FA were significantly correlated with several metabolic parameters. For women in menopause less than 6 years more correlations were obtained. Unsaturated cis FA (UFAcis), ω3, ω6, Polyunsaturated cis FA (PUFA) and Short-Chain FA (SCFA) were linked with anti-inflammatory activity whereas PUFAtrans, Monounsaturated cis FA (MUFAcis), Saturated FA(SFA) and ω9 were associated with pro-inflammatory pathways. Conclusion: FA have a role in both processes: protective and inflammatory, in postmenopausal obese/overweight women. Thus, the understanding of the inflammatory pathways can begin a new perspective in the follow-up for this high metabolic risk population. © 2018 Elsevier Ltd
Original languageEnglish
Pages (from-to)8-15
Number of pages8
JournalObesity Medicine
Volume10
DOIs
Publication statusPublished - 2018

Fingerprint

Metabolome
NSC 153174
Fatty Acids
Biomarkers
Menopause
Unsaturated Fatty Acids
Anti-Inflammatory Agents
Monounsaturated Fatty Acids
Volatile Fatty Acids
Hand
Obesity
Gases
Regression Analysis
Inflammation
Population

Keywords

  • Fatty acids
  • Inflammation
  • Menopause
  • Metabolic risk
  • Obesity
  • biological marker
  • fatty acid
  • monounsaturated fatty acid
  • polyunsaturated fatty acid
  • saturated fatty acid
  • short chain fatty acid
  • unsaturated fatty acid
  • adult
  • aged
  • Article
  • blood analysis
  • body mass
  • Caucasian
  • clinical article
  • disease association
  • fatty acid analysis
  • fatty acid blood level
  • female
  • follow up
  • gas chromatography
  • human
  • obesity
  • Portuguese (citizen)
  • postmenopause
  • priority journal
  • women's health

Cite this

@article{24a4b60870274cbca08346d24469bdcf,
title = "The relationship of plasma fatty acid profile and metabolic biomarkers among postmenopausal obese and overweight women",
abstract = "Aims: Considering some fatty acids (FA) have anti-inflammatory effects and by other hand obesity and menopause are associated with pro-inflammation, we aimed to investigate the impact of different FA on metabolic parameters among postmenopausal women obese/overweight. Additionally, since after menopause it takes some years for hormonal changes came to an end, the years past menopause (YPM) and the use of hormonal replacement therapy (HRT) were considered. Methods: Blood from 50 Portuguese Caucasian postmenopausal women was collected. FA plasma profile was evaluated by Gas Chromatography–FID (GC-FID). Metabolic parameters analyses were performed in a certified Clinical Analysis Laboratory. Regressions analyses were used to find correlations between FA and metabolic parameters. Results: FA were significantly correlated with several metabolic parameters. For women in menopause less than 6 years more correlations were obtained. Unsaturated cis FA (UFAcis), ω3, ω6, Polyunsaturated cis FA (PUFA) and Short-Chain FA (SCFA) were linked with anti-inflammatory activity whereas PUFAtrans, Monounsaturated cis FA (MUFAcis), Saturated FA(SFA) and ω9 were associated with pro-inflammatory pathways. Conclusion: FA have a role in both processes: protective and inflammatory, in postmenopausal obese/overweight women. Thus, the understanding of the inflammatory pathways can begin a new perspective in the follow-up for this high metabolic risk population. {\circledC} 2018 Elsevier Ltd",
keywords = "Fatty acids, Inflammation, Menopause, Metabolic risk, Obesity, biological marker, fatty acid, monounsaturated fatty acid, polyunsaturated fatty acid, saturated fatty acid, short chain fatty acid, unsaturated fatty acid, adult, aged, Article, blood analysis, body mass, Caucasian, clinical article, disease association, fatty acid analysis, fatty acid blood level, female, follow up, gas chromatography, human, obesity, Portuguese (citizen), postmenopause, priority journal, women's health",
author = "S. Sousa and D. Teixeira and C. Santos and C. Delerue-Matos and C. Calhau and V.F. Domingues",
note = "Export Date: 3 May 2018 Correspondence Address: Domingues, V.F.; REQUIMTE/LAQV-GRAQ, Instituto Superior de Engenharia do Porto, Instituto Polit{\'e}cnico do Porto, Rua Dr. Ant{\'o}nio Bernardino de Almeida, 431, Portugal; email: vfd@isep.ipp.pt Funding details: UID/QUI/50006/2013, FCT, Funda{\cc}{\~a}o para a Ci{\^e}ncia e a Tecnologia Funding details: China National Funds for Distinguished Young Scientists Funding details: NORTE-07-0124-FEDER-000069 Funding details: COMPETE, EGU, European Geosciences Union Funding text: This work received financial support from the European Union ( FEDER funds through COMPETE) and National Funds ( Funda{\cc}{\~a}o para a Ci{\^e}ncia e a Tecnologia ) through project UID/QUI/50006/2013 , and from the European Union (FEDER funds) under the framework of QREN through Project NORTE-07-0124-FEDER-000069 (ALIMENTO). Appendix A References: Bacon, J.L., The menopausal transition (2017) Obstet. Gynecol. Clin. North Am., 44, pp. 285-296; Becerra, N.L., Needleman, B., Noria, S., Bradley, D., Obstructive sleep apnea: is it a biomarker of metabolic health in obesity (2017) Obes. Med, 6, pp. 23-29; Bondia-Pons, I., Molt{\'o}-Puigmart{\'i}, C., Castellote, A.I., L{\'o}pez-Sabater, M.C., Determination of conjugated linoleic acid in human plasma by fast gas chromatography (2007) J. Chromatogr. A, 1157, pp. 422-429; Cooke, A.A., Connaughton, R.M., Lyons, C.L., McMorrow, A.M., Roche, H.M., Fatty acids and chronic low grade inflammation associated with obesity and the metabolic syndrome (2016) Eur. J. Pharmacol., 785, pp. 207-214; Dasgupta, A., Liver enzymes as alcohol biomarkers (2015) Alcohol and its Biomarkers, pp. 121-137; Derby, C.A., Crawford, S.L., Pasternak, R.C., Sowers, M., Sternfeld, B., Matthews, K.A., Lipid changes during the menopause transition in relation to age and weight: the study of Women's health across the nation (2009) Am. J. Epidemiol., 169, pp. 1352-1361; Ettinger, S., Nutritional Pathophysiology of Obesity and its Comorbidities a Case-study Approach (2017), Elsevier; Friedewald, W.T., Levy, R.I., Fredrickson, D.S., Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge (1972) Clin. Chem., 18, pp. 499-502; Garrel, G., Simon, V., Denoyelle, C., Ishaq, M., Rouch, C., Dairou, J., Magnan, C., Cohen-Tannoudji, J., Unsaturated fatty acids disrupt smad signaling in gonadotrope cells leading to inhibition of FSHβ gene expression (2014) Endocrinology, 155, pp. 592-604; Gibas-Dorna, M., Piątek, J., Kupsz, J., Bernatek, M., Krauss, H., Sowińska, A., Kołodziejski, P., Bojar, I., Relationship between adipokines and lipid profile in postmenopausal women with different apolipoprotein E genotypes (2016) Women Health, pp. 1-14; Gillingham, L.G., Harris-Janz, S., Jones, P.J.H., Dietary monounsaturated fatty acids are protective against metabolic syndrome and cardiovascular disease risk factors (2011) Lipids, 46, pp. 209-228; Glatz, J.F.C., Luiken, J.J.F.P., Fatty acids in cell signaling: historical perspective and future outlook (2014) Prostaglandins Leukot. Essent. Fat. Acids, 92, pp. 57-62; Goodman, N.F., Cobin, R.H., Ginzburg, S.B., Katz, I.A., Woode, D.E., AACE medical Guidelines for clinical practice for the diagnosis and treatment of menopause (2011) Endocr. Pract., 17, pp. 1-25; Hammad, S.S., Jones, P.J., Dietary fatty acid composition modulates obesity and interacts with obesity-related genes (2017) Lipids, 52, pp. 803-822; Hua, H., Liang, Q., Chen, J., Wang, Y., Development of a derivatization-free gc-fid method for evaluation of free fatty acid levels in plasma of diabetic nephropathy patients (2011) Chem. Res. Chin. Univ., 27, pp. 578-583; Kirwan, A.M., Lenighan, Y.M., O'Reilly, M.E., McGillicuddy, F.C., Roche, H.M., Nutritional modulation of metabolic inflammation (2017) Biochem. Soc. Trans., , BST20160465; Lee, A.R., Pechenino, A.S., Dong, H., Hammock, B.D., Knowlton, A.A., Aging, estrogen loss and epoxyeicosatrienoic acids (EETs) (2013) PLoS One, 8, pp. 1-8; Liu, P., Ji, Y., Yuen, T., Rendina-Ruedy, E., DeMambro, V.E., Dhawan, S., Abu-Amer, W., Zaidi, M., Blocking FSH induces thermogenic adipose tissue and reduces body fat (2017) Nature, 546, pp. 107-112; Masoodi, M., Kuda, O., Rossmeisl, M., Flachs, P., Kopecky, J., Lipid signaling in adipose tissue: connecting inflammation & metabolism (2014) Biochim. Biophys. Acta Mol. Cell Biol. Lipids; Mazidi, M., Gao, H., Shivappa, N., Wirth, M.D., Hebert, J.R., Kengne, A.P., The relationship of plasma Trans fatty acids with dietary inflammatory index among US adults (2017) Lipids Health Dis., 16, p. 147; Medeiros, N., Colato, A.S., de Abreu, F.G., de Lemos, L.S., Fraga, L.C., Funchal, C., Dani, C., Influence of different frequencies of deep water running on oxidative profile and insulin resistance in obese women (2016) Obes. Med, 2, pp. 37-40; Monteiro, R., Teixeira, D., Calhau, C., Estrogen signaling in metabolic inflammation (2014) Mediators Inflamm, 2014; Moon, S.-S., Relationship between serum uric acid level and nonalcoholic fatty liver disease in pre- and postmenopausal women (2013) Ann. Nutr. Metab., 62, pp. 158-163; Mozaffarian, D., Pischon, T., Hankinson, S.E., Rifai, N., Joshipura, K., Willett, W.C., Rimm, E.B., Dietary intake of trans fatty acids and systemic inflammation in women (2004) Am. J. Clin. Nutr., 79, pp. 606-612; Muhlhausler, B.S., Leghi, G.E., Polyunsaturated fatty acids, cholesterol, triglycerides and cardiometabolic disease (2016) Handbook of Cholesterol : Biology, Function and Role in Health and Diseases, pp. 335-354. , 18; Oh, E.J., Choi, J., Kim, S., Ahn, A., Park, C.K., Body volume, body fatness, and metabolic syndrome (2016) Women Health, 242, pp. 1-15; Paszkowski, T., Kłodnicka, M., Hormonal replacement therapy and obesity (2007) Menopause Rev. Menopauzalny, 6, pp. 106-109; Rosano, G.M.C., Vitale, C., Marazzi, G., Volterrani, M., Menopause and cardiovascular disease: the evidence (2007) Climacteric, 10, pp. 19-24; Rose, M., Veysey, M., Lucock, M., Niblett, S., King, K., Baines, S., Garg, M.L., Association between erythrocyte omega-3 polyunsaturated fatty acid levels and fatty liver index in older people is sex dependent (2016) J. Nutr. Intermed. Metab, 5, pp. 78-85; Saravanan, P., Davidson, N.C., Schmidt, E.B., Calder, P.C., Cardiovascular effects of marine omega-3 fatty acids (2010) Lancet, 376, pp. 540-550; Sepp{\"a}nen-Laakso, T., Laakso, I., Hiltunen, R., Analysis of fatty acids by gas chromatography, and its relevance to research on health and nutrition (2002) Anal. Chim. Acta, 465, pp. 39-62; Song, Y., Wang, E.S., Xing, L.L., Shi, S., Qu, F., Zhang, D., Li, J.Y., Huang, H.F., Follicle-stimulating hormone induces postmenopausal dyslipidemia through inhibiting hepatic cholesterol metabolism (2016) J. Clin. Endocrinol. Metab., 101, pp. 254-263; Tardivo, A.P., Nahas-Neto, J., Orsatti, C.L., Dias, F.B., Poloni, P.F., Schmitt, E.B., Nahas, E.A.P., Effects of omega-3 on metabolic markers in postmenopausal women with metabolic syndrome (2015) Climacteric, 18, pp. 290-298; Telle-Hansen, V.H., Christensen, J.J., Ulven, S.M., Holven, K.B., Does dietary fat affect inflammatory markers in overweight and obese individuals?-a review of randomized controlled trials from 2010 to 2016 (2017) Genes Nutr, 12, p. 26; Tsokos, M., Reichelt, U., Nierhaus, A., P{\"u}schel, K., Serum procalcitonin (PCT): a valuable biochemical parameter for the post-mortem diagnosis of sepsis (2001) Int. J. Legal Med, 114, pp. 237-243; Ubhayasekera, S.J.K.J., Staaf, J., Forslund, A., Bergsten, P., Bergquist, J., Free fatty acid determination in plasma by GC-MS after conversion to Weinreb amides (2013) Anal. Bioanal. Chem., 405, pp. 1929-1935; Vicente, S.E.D.C.F., Corgosinho, F.C., Campos, R.M.D.S., Masquio, D.C.L., Oliveira e Silva, L., Kravchychyn, A.C.P., Sanches, P.D.L., D{\^a}maso, A.R., The impact of adiponectin levels on biomarkers of inflammation among adolescents with obesity (2017) Obes. Med, 5, pp. 4-10; Vinolo, M.A.R., Rodrigues, H.G., Nachbar, R.T., Curi, R., Regulation of inflammation by short chain fatty acids (2011) Nutrients, 3, pp. 858-876; Wang, L., Sikand, G., Wong, N.D., Nutrition, diet quality, and cardiovascular health (2016) Molecular Basis of Nutrition and Aging, pp. 315-330. , Elsevier; Yamatani, H., Takahashi, K., Yoshida, T., Soga, T., Kurachi, H., Differences in the fatty acid metabolism of visceral adipose tissue in postmenopausal women. Menopause (2014) J. North Am. Menopause Soc., 21, pp. 170-176",
year = "2018",
doi = "10.1016/j.obmed.2018.02.002",
language = "English",
volume = "10",
pages = "8--15",
journal = "Obesity Medicine",
issn = "2451-8476",
publisher = "Elsevier Ltd.",

}

The relationship of plasma fatty acid profile and metabolic biomarkers among postmenopausal obese and overweight women. / Sousa, S.; Teixeira, D.; Santos, C.; Delerue-Matos, C.; Calhau, C.; Domingues, V.F.

In: Obesity Medicine, Vol. 10, 2018, p. 8-15.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The relationship of plasma fatty acid profile and metabolic biomarkers among postmenopausal obese and overweight women

AU - Sousa, S.

AU - Teixeira, D.

AU - Santos, C.

AU - Delerue-Matos, C.

AU - Calhau, C.

AU - Domingues, V.F.

N1 - Export Date: 3 May 2018 Correspondence Address: Domingues, V.F.; REQUIMTE/LAQV-GRAQ, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida, 431, Portugal; email: vfd@isep.ipp.pt Funding details: UID/QUI/50006/2013, FCT, Fundação para a Ciência e a Tecnologia Funding details: China National Funds for Distinguished Young Scientists Funding details: NORTE-07-0124-FEDER-000069 Funding details: COMPETE, EGU, European Geosciences Union Funding text: This work received financial support from the European Union ( FEDER funds through COMPETE) and National Funds ( Fundação para a Ciência e a Tecnologia ) through project UID/QUI/50006/2013 , and from the European Union (FEDER funds) under the framework of QREN through Project NORTE-07-0124-FEDER-000069 (ALIMENTO). Appendix A References: Bacon, J.L., The menopausal transition (2017) Obstet. Gynecol. Clin. North Am., 44, pp. 285-296; Becerra, N.L., Needleman, B., Noria, S., Bradley, D., Obstructive sleep apnea: is it a biomarker of metabolic health in obesity (2017) Obes. Med, 6, pp. 23-29; Bondia-Pons, I., Moltó-Puigmartí, C., Castellote, A.I., López-Sabater, M.C., Determination of conjugated linoleic acid in human plasma by fast gas chromatography (2007) J. Chromatogr. A, 1157, pp. 422-429; Cooke, A.A., Connaughton, R.M., Lyons, C.L., McMorrow, A.M., Roche, H.M., Fatty acids and chronic low grade inflammation associated with obesity and the metabolic syndrome (2016) Eur. J. Pharmacol., 785, pp. 207-214; Dasgupta, A., Liver enzymes as alcohol biomarkers (2015) Alcohol and its Biomarkers, pp. 121-137; Derby, C.A., Crawford, S.L., Pasternak, R.C., Sowers, M., Sternfeld, B., Matthews, K.A., Lipid changes during the menopause transition in relation to age and weight: the study of Women's health across the nation (2009) Am. J. Epidemiol., 169, pp. 1352-1361; Ettinger, S., Nutritional Pathophysiology of Obesity and its Comorbidities a Case-study Approach (2017), Elsevier; Friedewald, W.T., Levy, R.I., Fredrickson, D.S., Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge (1972) Clin. Chem., 18, pp. 499-502; Garrel, G., Simon, V., Denoyelle, C., Ishaq, M., Rouch, C., Dairou, J., Magnan, C., Cohen-Tannoudji, J., Unsaturated fatty acids disrupt smad signaling in gonadotrope cells leading to inhibition of FSHβ gene expression (2014) Endocrinology, 155, pp. 592-604; Gibas-Dorna, M., Piątek, J., Kupsz, J., Bernatek, M., Krauss, H., Sowińska, A., Kołodziejski, P., Bojar, I., Relationship between adipokines and lipid profile in postmenopausal women with different apolipoprotein E genotypes (2016) Women Health, pp. 1-14; Gillingham, L.G., Harris-Janz, S., Jones, P.J.H., Dietary monounsaturated fatty acids are protective against metabolic syndrome and cardiovascular disease risk factors (2011) Lipids, 46, pp. 209-228; Glatz, J.F.C., Luiken, J.J.F.P., Fatty acids in cell signaling: historical perspective and future outlook (2014) Prostaglandins Leukot. Essent. Fat. Acids, 92, pp. 57-62; Goodman, N.F., Cobin, R.H., Ginzburg, S.B., Katz, I.A., Woode, D.E., AACE medical Guidelines for clinical practice for the diagnosis and treatment of menopause (2011) Endocr. Pract., 17, pp. 1-25; Hammad, S.S., Jones, P.J., Dietary fatty acid composition modulates obesity and interacts with obesity-related genes (2017) Lipids, 52, pp. 803-822; Hua, H., Liang, Q., Chen, J., Wang, Y., Development of a derivatization-free gc-fid method for evaluation of free fatty acid levels in plasma of diabetic nephropathy patients (2011) Chem. Res. Chin. Univ., 27, pp. 578-583; Kirwan, A.M., Lenighan, Y.M., O'Reilly, M.E., McGillicuddy, F.C., Roche, H.M., Nutritional modulation of metabolic inflammation (2017) Biochem. Soc. Trans., , BST20160465; Lee, A.R., Pechenino, A.S., Dong, H., Hammock, B.D., Knowlton, A.A., Aging, estrogen loss and epoxyeicosatrienoic acids (EETs) (2013) PLoS One, 8, pp. 1-8; Liu, P., Ji, Y., Yuen, T., Rendina-Ruedy, E., DeMambro, V.E., Dhawan, S., Abu-Amer, W., Zaidi, M., Blocking FSH induces thermogenic adipose tissue and reduces body fat (2017) Nature, 546, pp. 107-112; Masoodi, M., Kuda, O., Rossmeisl, M., Flachs, P., Kopecky, J., Lipid signaling in adipose tissue: connecting inflammation & metabolism (2014) Biochim. Biophys. Acta Mol. Cell Biol. Lipids; Mazidi, M., Gao, H., Shivappa, N., Wirth, M.D., Hebert, J.R., Kengne, A.P., The relationship of plasma Trans fatty acids with dietary inflammatory index among US adults (2017) Lipids Health Dis., 16, p. 147; Medeiros, N., Colato, A.S., de Abreu, F.G., de Lemos, L.S., Fraga, L.C., Funchal, C., Dani, C., Influence of different frequencies of deep water running on oxidative profile and insulin resistance in obese women (2016) Obes. Med, 2, pp. 37-40; Monteiro, R., Teixeira, D., Calhau, C., Estrogen signaling in metabolic inflammation (2014) Mediators Inflamm, 2014; Moon, S.-S., Relationship between serum uric acid level and nonalcoholic fatty liver disease in pre- and postmenopausal women (2013) Ann. Nutr. Metab., 62, pp. 158-163; Mozaffarian, D., Pischon, T., Hankinson, S.E., Rifai, N., Joshipura, K., Willett, W.C., Rimm, E.B., Dietary intake of trans fatty acids and systemic inflammation in women (2004) Am. J. Clin. Nutr., 79, pp. 606-612; Muhlhausler, B.S., Leghi, G.E., Polyunsaturated fatty acids, cholesterol, triglycerides and cardiometabolic disease (2016) Handbook of Cholesterol : Biology, Function and Role in Health and Diseases, pp. 335-354. , 18; Oh, E.J., Choi, J., Kim, S., Ahn, A., Park, C.K., Body volume, body fatness, and metabolic syndrome (2016) Women Health, 242, pp. 1-15; Paszkowski, T., Kłodnicka, M., Hormonal replacement therapy and obesity (2007) Menopause Rev. Menopauzalny, 6, pp. 106-109; Rosano, G.M.C., Vitale, C., Marazzi, G., Volterrani, M., Menopause and cardiovascular disease: the evidence (2007) Climacteric, 10, pp. 19-24; Rose, M., Veysey, M., Lucock, M., Niblett, S., King, K., Baines, S., Garg, M.L., Association between erythrocyte omega-3 polyunsaturated fatty acid levels and fatty liver index in older people is sex dependent (2016) J. Nutr. Intermed. Metab, 5, pp. 78-85; Saravanan, P., Davidson, N.C., Schmidt, E.B., Calder, P.C., Cardiovascular effects of marine omega-3 fatty acids (2010) Lancet, 376, pp. 540-550; Seppänen-Laakso, T., Laakso, I., Hiltunen, R., Analysis of fatty acids by gas chromatography, and its relevance to research on health and nutrition (2002) Anal. Chim. Acta, 465, pp. 39-62; Song, Y., Wang, E.S., Xing, L.L., Shi, S., Qu, F., Zhang, D., Li, J.Y., Huang, H.F., Follicle-stimulating hormone induces postmenopausal dyslipidemia through inhibiting hepatic cholesterol metabolism (2016) J. Clin. Endocrinol. Metab., 101, pp. 254-263; Tardivo, A.P., Nahas-Neto, J., Orsatti, C.L., Dias, F.B., Poloni, P.F., Schmitt, E.B., Nahas, E.A.P., Effects of omega-3 on metabolic markers in postmenopausal women with metabolic syndrome (2015) Climacteric, 18, pp. 290-298; Telle-Hansen, V.H., Christensen, J.J., Ulven, S.M., Holven, K.B., Does dietary fat affect inflammatory markers in overweight and obese individuals?-a review of randomized controlled trials from 2010 to 2016 (2017) Genes Nutr, 12, p. 26; Tsokos, M., Reichelt, U., Nierhaus, A., Püschel, K., Serum procalcitonin (PCT): a valuable biochemical parameter for the post-mortem diagnosis of sepsis (2001) Int. J. Legal Med, 114, pp. 237-243; Ubhayasekera, S.J.K.J., Staaf, J., Forslund, A., Bergsten, P., Bergquist, J., Free fatty acid determination in plasma by GC-MS after conversion to Weinreb amides (2013) Anal. Bioanal. Chem., 405, pp. 1929-1935; Vicente, S.E.D.C.F., Corgosinho, F.C., Campos, R.M.D.S., Masquio, D.C.L., Oliveira e Silva, L., Kravchychyn, A.C.P., Sanches, P.D.L., Dâmaso, A.R., The impact of adiponectin levels on biomarkers of inflammation among adolescents with obesity (2017) Obes. Med, 5, pp. 4-10; Vinolo, M.A.R., Rodrigues, H.G., Nachbar, R.T., Curi, R., Regulation of inflammation by short chain fatty acids (2011) Nutrients, 3, pp. 858-876; Wang, L., Sikand, G., Wong, N.D., Nutrition, diet quality, and cardiovascular health (2016) Molecular Basis of Nutrition and Aging, pp. 315-330. , Elsevier; Yamatani, H., Takahashi, K., Yoshida, T., Soga, T., Kurachi, H., Differences in the fatty acid metabolism of visceral adipose tissue in postmenopausal women. Menopause (2014) J. North Am. Menopause Soc., 21, pp. 170-176

PY - 2018

Y1 - 2018

N2 - Aims: Considering some fatty acids (FA) have anti-inflammatory effects and by other hand obesity and menopause are associated with pro-inflammation, we aimed to investigate the impact of different FA on metabolic parameters among postmenopausal women obese/overweight. Additionally, since after menopause it takes some years for hormonal changes came to an end, the years past menopause (YPM) and the use of hormonal replacement therapy (HRT) were considered. Methods: Blood from 50 Portuguese Caucasian postmenopausal women was collected. FA plasma profile was evaluated by Gas Chromatography–FID (GC-FID). Metabolic parameters analyses were performed in a certified Clinical Analysis Laboratory. Regressions analyses were used to find correlations between FA and metabolic parameters. Results: FA were significantly correlated with several metabolic parameters. For women in menopause less than 6 years more correlations were obtained. Unsaturated cis FA (UFAcis), ω3, ω6, Polyunsaturated cis FA (PUFA) and Short-Chain FA (SCFA) were linked with anti-inflammatory activity whereas PUFAtrans, Monounsaturated cis FA (MUFAcis), Saturated FA(SFA) and ω9 were associated with pro-inflammatory pathways. Conclusion: FA have a role in both processes: protective and inflammatory, in postmenopausal obese/overweight women. Thus, the understanding of the inflammatory pathways can begin a new perspective in the follow-up for this high metabolic risk population. © 2018 Elsevier Ltd

AB - Aims: Considering some fatty acids (FA) have anti-inflammatory effects and by other hand obesity and menopause are associated with pro-inflammation, we aimed to investigate the impact of different FA on metabolic parameters among postmenopausal women obese/overweight. Additionally, since after menopause it takes some years for hormonal changes came to an end, the years past menopause (YPM) and the use of hormonal replacement therapy (HRT) were considered. Methods: Blood from 50 Portuguese Caucasian postmenopausal women was collected. FA plasma profile was evaluated by Gas Chromatography–FID (GC-FID). Metabolic parameters analyses were performed in a certified Clinical Analysis Laboratory. Regressions analyses were used to find correlations between FA and metabolic parameters. Results: FA were significantly correlated with several metabolic parameters. For women in menopause less than 6 years more correlations were obtained. Unsaturated cis FA (UFAcis), ω3, ω6, Polyunsaturated cis FA (PUFA) and Short-Chain FA (SCFA) were linked with anti-inflammatory activity whereas PUFAtrans, Monounsaturated cis FA (MUFAcis), Saturated FA(SFA) and ω9 were associated with pro-inflammatory pathways. Conclusion: FA have a role in both processes: protective and inflammatory, in postmenopausal obese/overweight women. Thus, the understanding of the inflammatory pathways can begin a new perspective in the follow-up for this high metabolic risk population. © 2018 Elsevier Ltd

KW - Fatty acids

KW - Inflammation

KW - Menopause

KW - Metabolic risk

KW - Obesity

KW - biological marker

KW - fatty acid

KW - monounsaturated fatty acid

KW - polyunsaturated fatty acid

KW - saturated fatty acid

KW - short chain fatty acid

KW - unsaturated fatty acid

KW - adult

KW - aged

KW - Article

KW - blood analysis

KW - body mass

KW - Caucasian

KW - clinical article

KW - disease association

KW - fatty acid analysis

KW - fatty acid blood level

KW - female

KW - follow up

KW - gas chromatography

KW - human

KW - obesity

KW - Portuguese (citizen)

KW - postmenopause

KW - priority journal

KW - women's health

U2 - 10.1016/j.obmed.2018.02.002

DO - 10.1016/j.obmed.2018.02.002

M3 - Article

VL - 10

SP - 8

EP - 15

JO - Obesity Medicine

JF - Obesity Medicine

SN - 2451-8476

ER -