TY - JOUR
T1 - The relationship of plasma fatty acid profile and metabolic biomarkers among postmenopausal obese and overweight women
AU - Sousa, S.
AU - Teixeira, D.
AU - Santos, C.
AU - Delerue-Matos, C.
AU - Calhau, C.
AU - Domingues, V.F.
N1 - Export Date: 3 May 2018
Correspondence Address: Domingues, V.F.; REQUIMTE/LAQV-GRAQ, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida, 431, Portugal; email: [email protected]
Funding details: UID/QUI/50006/2013, FCT, Fundação para a Ciência e a Tecnologia
Funding details: China National Funds for Distinguished Young Scientists
Funding details: NORTE-07-0124-FEDER-000069
Funding details: COMPETE, EGU, European Geosciences Union
Funding text: This work received financial support from the European Union ( FEDER funds through COMPETE) and National Funds ( Fundação para a Ciência e a Tecnologia ) through project UID/QUI/50006/2013 , and from the European Union (FEDER funds) under the framework of QREN through Project NORTE-07-0124-FEDER-000069 (ALIMENTO). Appendix A
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PY - 2018
Y1 - 2018
N2 - Aims: Considering some fatty acids (FA) have anti-inflammatory effects and by other hand obesity and menopause are associated with pro-inflammation, we aimed to investigate the impact of different FA on metabolic parameters among postmenopausal women obese/overweight. Additionally, since after menopause it takes some years for hormonal changes came to an end, the years past menopause (YPM) and the use of hormonal replacement therapy (HRT) were considered. Methods: Blood from 50 Portuguese Caucasian postmenopausal women was collected. FA plasma profile was evaluated by Gas Chromatography–FID (GC-FID). Metabolic parameters analyses were performed in a certified Clinical Analysis Laboratory. Regressions analyses were used to find correlations between FA and metabolic parameters. Results: FA were significantly correlated with several metabolic parameters. For women in menopause less than 6 years more correlations were obtained. Unsaturated cis FA (UFAcis), ω3, ω6, Polyunsaturated cis FA (PUFA) and Short-Chain FA (SCFA) were linked with anti-inflammatory activity whereas PUFAtrans, Monounsaturated cis FA (MUFAcis), Saturated FA(SFA) and ω9 were associated with pro-inflammatory pathways. Conclusion: FA have a role in both processes: protective and inflammatory, in postmenopausal obese/overweight women. Thus, the understanding of the inflammatory pathways can begin a new perspective in the follow-up for this high metabolic risk population. © 2018 Elsevier Ltd
AB - Aims: Considering some fatty acids (FA) have anti-inflammatory effects and by other hand obesity and menopause are associated with pro-inflammation, we aimed to investigate the impact of different FA on metabolic parameters among postmenopausal women obese/overweight. Additionally, since after menopause it takes some years for hormonal changes came to an end, the years past menopause (YPM) and the use of hormonal replacement therapy (HRT) were considered. Methods: Blood from 50 Portuguese Caucasian postmenopausal women was collected. FA plasma profile was evaluated by Gas Chromatography–FID (GC-FID). Metabolic parameters analyses were performed in a certified Clinical Analysis Laboratory. Regressions analyses were used to find correlations between FA and metabolic parameters. Results: FA were significantly correlated with several metabolic parameters. For women in menopause less than 6 years more correlations were obtained. Unsaturated cis FA (UFAcis), ω3, ω6, Polyunsaturated cis FA (PUFA) and Short-Chain FA (SCFA) were linked with anti-inflammatory activity whereas PUFAtrans, Monounsaturated cis FA (MUFAcis), Saturated FA(SFA) and ω9 were associated with pro-inflammatory pathways. Conclusion: FA have a role in both processes: protective and inflammatory, in postmenopausal obese/overweight women. Thus, the understanding of the inflammatory pathways can begin a new perspective in the follow-up for this high metabolic risk population. © 2018 Elsevier Ltd
KW - Fatty acids
KW - Inflammation
KW - Menopause
KW - Metabolic risk
KW - Obesity
KW - biological marker
KW - fatty acid
KW - monounsaturated fatty acid
KW - polyunsaturated fatty acid
KW - saturated fatty acid
KW - short chain fatty acid
KW - unsaturated fatty acid
KW - adult
KW - aged
KW - Article
KW - blood analysis
KW - body mass
KW - Caucasian
KW - clinical article
KW - disease association
KW - fatty acid analysis
KW - fatty acid blood level
KW - female
KW - follow up
KW - gas chromatography
KW - human
KW - obesity
KW - Portuguese (citizen)
KW - postmenopause
KW - priority journal
KW - women's health
U2 - 10.1016/j.obmed.2018.02.002
DO - 10.1016/j.obmed.2018.02.002
M3 - Article
SN - 2451-8476
VL - 10
SP - 8
EP - 15
JO - Obesity Medicine
JF - Obesity Medicine
ER -
