The relationship of plasma fatty acid profile and metabolic biomarkers among postmenopausal obese and overweight women

S. Sousa, D. Teixeira, C. Santos, C. Delerue-Matos, C. Calhau, V.F. Domingues

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Aims: Considering some fatty acids (FA) have anti-inflammatory effects and by other hand obesity and menopause are associated with pro-inflammation, we aimed to investigate the impact of different FA on metabolic parameters among postmenopausal women obese/overweight. Additionally, since after menopause it takes some years for hormonal changes came to an end, the years past menopause (YPM) and the use of hormonal replacement therapy (HRT) were considered. Methods: Blood from 50 Portuguese Caucasian postmenopausal women was collected. FA plasma profile was evaluated by Gas Chromatography–FID (GC-FID). Metabolic parameters analyses were performed in a certified Clinical Analysis Laboratory. Regressions analyses were used to find correlations between FA and metabolic parameters. Results: FA were significantly correlated with several metabolic parameters. For women in menopause less than 6 years more correlations were obtained. Unsaturated cis FA (UFAcis), ω3, ω6, Polyunsaturated cis FA (PUFA) and Short-Chain FA (SCFA) were linked with anti-inflammatory activity whereas PUFAtrans, Monounsaturated cis FA (MUFAcis), Saturated FA(SFA) and ω9 were associated with pro-inflammatory pathways. Conclusion: FA have a role in both processes: protective and inflammatory, in postmenopausal obese/overweight women. Thus, the understanding of the inflammatory pathways can begin a new perspective in the follow-up for this high metabolic risk population. © 2018 Elsevier Ltd
Original languageEnglish
Pages (from-to)8-15
Number of pages8
JournalObesity Medicine
Publication statusPublished - 2018


  • Fatty acids
  • Inflammation
  • Menopause
  • Metabolic risk
  • Obesity
  • biological marker
  • fatty acid
  • monounsaturated fatty acid
  • polyunsaturated fatty acid
  • saturated fatty acid
  • short chain fatty acid
  • unsaturated fatty acid
  • adult
  • aged
  • Article
  • blood analysis
  • body mass
  • Caucasian
  • clinical article
  • disease association
  • fatty acid analysis
  • fatty acid blood level
  • female
  • follow up
  • gas chromatography
  • human
  • obesity
  • Portuguese (citizen)
  • postmenopause
  • priority journal
  • women's health


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