The Portuguese Experience with Ocriplasmin in Clinical Practice

Joao Figueira, David Martins, Bernardete Pessoa, Natalia Ferreira, Angelina Meireles, Antonio Sampaio, Angela Carneiro, Fernanda Vaz, Joao Nascimento, Natacha Moreno, Jose Roque, Manuel Domingues, Rita Flores, Carla Teixeira, Eduardo Conde, Filipe Henriques, Helena Proenca, Jose Pita Negrao, Marisa Barbosa, Rufino SilvaSara Vaz-Pereira, Pedro Pereira Neves, Nuno Gomes, Miguel Raimundo, Jetrea Study Grp

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Aim: Evaluate the real-life experience with ocriplasmin on vitreomacular traction (VMT) release and full-thickness macular hole (FTMH) closure in Portugal. Methods: Multicentric, retrospective study of 83 eyes of 78 patients who were treated with intravitreal ocriplasmin for VMT with and without FTMH. Primary outcomes were VMT release and FTMH closure. Secondary outcomes included visual acuity changes and structural features on spectral-domain ocular coherence tomography. Results: VMT resolved in 47 of the 83 eyes (56.6%) and 6 of the 12 FTMH were closed (50.0%). Mean best-corrected visual acuity (BCVA) improved from 65.1 at baseline to 70.8 ETDRS letters at the end of follow-up (p textless 0.0001) with a mean follow-up of 138.8 days. Improvement in BCVA was significantly better in eyes with VMT release (p = 0.021). Approximately 73% of patients had normal ellipsoid zone integrity at the end of follow-up, 87% had no neurosensorial detachment and 40% had no intra- or subretinal fluid. Conclusion: VMT release and FTMH closure were achieved in more than half of the treated eyes and were correlated with significant BCVA improvements and favorable baseline characteristics. In fact, if a careful patient selection is carried out, VMT resolution with ocriplasmin can be optimized, tailoring the best apprbach to each patient. (C) 2016 S. Karger AG, Basel
Original languageEnglish
Pages (from-to)186-192
Number of pages7
JournalOphthalmic research
Volume56
Issue number4
DOIs
Publication statusPublished - 2016

Keywords

  • Optical coherence tomography
  • Ocriplasmin
  • Vitreomacular traction
  • Macular hole

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