The multiple functions of the numerous chlamydia trachomatis secreted proteins: The tip of the iceberg

Research output: Contribution to journalReview article

Abstract

Chlamydia trachomatis serovars are obligate intracellular bacterial pathogens mainly causing ocular and urogenital infections that affect millions of people worldwide and which can lead to blindness or sterility. They reside and multiply intracellularly within a membrane-bound vacuolar compartment, known as inclusion, and are characterized by a developmental cycle involving two morpho-logically and physiologically distinct chlamydial forms. Completion of the developmental cycle involves the secretion of > 70 C. trachomatis proteins that function in the host cell cytoplasm and nucleus, in the inclusion membrane and lumen, and in the extracellular milieu. These proteins can, for example, interfere with the host cell cytoskeleton, vesicular and non-vesicular transport, metabolism, and immune signalling. Generally, this promotes C. trachomatis invasion into, and escape from, host cells, the acquisition of nutrients by the chlamydiae, and evasion of cell-autonomous, humoral and cellular innate immunity. Here, we present an in-depth review on the current knowledge and outstanding questions about these C. trachomatis secreted proteins.

Original languageEnglish
Pages (from-to)414-449
Number of pages36
JournalMicrobial Cell
Volume6
Issue number9
DOIs
Publication statusPublished - 1 Sep 2019

Fingerprint

Chlamydia trachomatis
Membranes
Proteins
Pathogens
Eye Infections
Metabolism
Nutrients
Chlamydia
Blindness
Cytoskeleton
Cell Nucleus
Innate Immunity
Cellular Immunity
Infertility
Cytoplasm
Food

Keywords

  • Chlamydia trachomatis
  • Effectors
  • Host-pathogen interactions
  • Protein secretion
  • Type III secretion

Cite this

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title = "The multiple functions of the numerous chlamydia trachomatis secreted proteins: The tip of the iceberg",
abstract = "Chlamydia trachomatis serovars are obligate intracellular bacterial pathogens mainly causing ocular and urogenital infections that affect millions of people worldwide and which can lead to blindness or sterility. They reside and multiply intracellularly within a membrane-bound vacuolar compartment, known as inclusion, and are characterized by a developmental cycle involving two morpho-logically and physiologically distinct chlamydial forms. Completion of the developmental cycle involves the secretion of > 70 C. trachomatis proteins that function in the host cell cytoplasm and nucleus, in the inclusion membrane and lumen, and in the extracellular milieu. These proteins can, for example, interfere with the host cell cytoskeleton, vesicular and non-vesicular transport, metabolism, and immune signalling. Generally, this promotes C. trachomatis invasion into, and escape from, host cells, the acquisition of nutrients by the chlamydiae, and evasion of cell-autonomous, humoral and cellular innate immunity. Here, we present an in-depth review on the current knowledge and outstanding questions about these C. trachomatis secreted proteins.",
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author = "Bugalh{\~a}o, {Joana N.} and Mota, {Lu{\'i}s Jaime}",
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The multiple functions of the numerous chlamydia trachomatis secreted proteins: The tip of the iceberg. / Bugalhão, Joana N.; Mota, Luís Jaime.

In: Microbial Cell, Vol. 6, No. 9, 01.09.2019, p. 414-449.

Research output: Contribution to journalReview article

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