Abstract
The mercapturate pathway is a unique metabolic circuitry that detoxifies electrophiles upon adducts formation with glutathione. Since its discovery over a century ago, most of the knowledge on the mercapturate pathway has been provided from biomonitoring studies on environmental exposure to toxicants. However, the mercapturate pathway-related metabolites that is formed in humans—the mercapturomic profile—in health and disease is yet to be established. In this paper, we put forward the hypothesis that these metabolites are key pathophysiologic factors behind the onset and development of non-communicable chronic inflammatory diseases. This review goes from the evidence in the formation of endogenous metabolites undergoing the mercapturate pathway to the methodologies for their assessment and their association with cancer and respiratory, neurologic and cardiometabolic diseases.
| Original language | English |
|---|---|
| Article number | 10 |
| Journal | High-Throughput |
| Volume | 8 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 Jun 2019 |
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Keywords
- Biomarkers
- Chronic inflammation
- Cysteine-S-conjugates
- Cysteinyl-leukotrienes
- Disulfides
- Dopamine
- Estrogen
- Mercapturate pathway
- Metabolomics
- N-acetyl-transferase 8
Cite this
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The mercapturomic profile of health and non-communicable diseases. / Gonçalves-Dias, Clara; Morello, Judit; Semedo, Valdir; Correia, M. João; Coelho, Nuno R.; Monteiro, Emilia C.; Antunes, Alexandra M.M.; Pereira, Sofia A.
In: High-Throughput, Vol. 8, No. 2, 10, 01.06.2019.Research output: Contribution to journal › Review article
TY - JOUR
T1 - The mercapturomic profile of health and non-communicable diseases
AU - Gonçalves-Dias, Clara
AU - Morello, Judit
AU - Semedo, Valdir
AU - Correia, M. João
AU - Coelho, Nuno R.
AU - Monteiro, Emilia C.
AU - Antunes, Alexandra M.M.
AU - Pereira, Sofia A.
N1 - info:eu-repo/grantAgreement/FCT/PD/PD%2FBD%2F105892%2F2014/PT# info:eu-repo/grantAgreement/FCT/5876/147260/PT# iNOVA4Health–UID/Multi/04462/2013, a program financially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement is acknowledged (Ref: 201601-02-021). Authors supported by Fundação para a Ciência e a Tecnologia (FCT–Portugal): for V.S.; PD/BD/105892/2014 for C.G.-D.;RNEM-LISBOA-01-0145-FEDER-022125022125 for J.M.; SFRH/BD/130911/2017 for M.J.C.; D/BD/114257/2016 for N.R.C.; Programa Operacional Potencial Humano and the European Social Fund (IF/01091/2013) for A.M.M.A.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - The mercapturate pathway is a unique metabolic circuitry that detoxifies electrophiles upon adducts formation with glutathione. Since its discovery over a century ago, most of the knowledge on the mercapturate pathway has been provided from biomonitoring studies on environmental exposure to toxicants. However, the mercapturate pathway-related metabolites that is formed in humans—the mercapturomic profile—in health and disease is yet to be established. In this paper, we put forward the hypothesis that these metabolites are key pathophysiologic factors behind the onset and development of non-communicable chronic inflammatory diseases. This review goes from the evidence in the formation of endogenous metabolites undergoing the mercapturate pathway to the methodologies for their assessment and their association with cancer and respiratory, neurologic and cardiometabolic diseases.
AB - The mercapturate pathway is a unique metabolic circuitry that detoxifies electrophiles upon adducts formation with glutathione. Since its discovery over a century ago, most of the knowledge on the mercapturate pathway has been provided from biomonitoring studies on environmental exposure to toxicants. However, the mercapturate pathway-related metabolites that is formed in humans—the mercapturomic profile—in health and disease is yet to be established. In this paper, we put forward the hypothesis that these metabolites are key pathophysiologic factors behind the onset and development of non-communicable chronic inflammatory diseases. This review goes from the evidence in the formation of endogenous metabolites undergoing the mercapturate pathway to the methodologies for their assessment and their association with cancer and respiratory, neurologic and cardiometabolic diseases.
KW - Biomarkers
KW - Chronic inflammation
KW - Cysteine-S-conjugates
KW - Cysteinyl-leukotrienes
KW - Disulfides
KW - Dopamine
KW - Estrogen
KW - Mercapturate pathway
KW - Metabolomics
KW - N-acetyl-transferase 8
UR - http://www.scopus.com/inward/record.url?scp=85067895174&partnerID=8YFLogxK
U2 - 10.3390/ht8020010
DO - 10.3390/ht8020010
M3 - Review article
VL - 8
JO - High-Throughput
JF - High-Throughput
SN - 2571-5135
IS - 2
M1 - 10
ER -