TY - JOUR
T1 - The mechanism by which the phenothiazine thioridazine contributes to cure problematic drug-resistant forms of pulmonary tuberculosis: recent patents for "new use".
AU - Amaral, Leonard
AU - Martins, Ana
PY - 2013/1/1
Y1 - 2013/1/1
N2 - At this moment, over half million patients suffer from multi-drug resistant tuberculosis (MDRTB) according to the data from the WHO. A large majority is terminally ill with essentially incurable pulmonary tuberculosis. This herein mini-review provides the experimental and observational evidence that a specific phenothiazine, thioridazine, will contribute to cure any form of drug-resistant tuberculosis. This antipsychotic agent is no longer under patent protection for its initial use. The reader is informed on the recent developments in patenting this compound for "new use" with a special emphasis on the aspects of drug-resistance, and, given that economic motivation can stimulate the use of this drug as an antitubercular agent, future prospects are also discussed.
AB - At this moment, over half million patients suffer from multi-drug resistant tuberculosis (MDRTB) according to the data from the WHO. A large majority is terminally ill with essentially incurable pulmonary tuberculosis. This herein mini-review provides the experimental and observational evidence that a specific phenothiazine, thioridazine, will contribute to cure any form of drug-resistant tuberculosis. This antipsychotic agent is no longer under patent protection for its initial use. The reader is informed on the recent developments in patenting this compound for "new use" with a special emphasis on the aspects of drug-resistance, and, given that economic motivation can stimulate the use of this drug as an antitubercular agent, future prospects are also discussed.
M3 - Article
C2 - 24320229
VL - Epub ahead
SP - Epub ahed
JO - Recent Patents On Anti-Infective Drug Discovery
JF - Recent Patents On Anti-Infective Drug Discovery
SN - 1574-891X
IS - NA
ER -