TY - JOUR
T1 - The in vitro activity of phenothiazines against Mycobacterium avium
T2 - potential of thioridazine for therapy of the co-infected AIDS patient
AU - Viveiros, Miguel
AU - Martins, Marta
AU - Couto, Isabel
AU - Kristiansen, Jette E.
AU - Molnar, Joseph
AU - Amaral, Leonard
PY - 2005/7
Y1 - 2005/7
N2 - Patients presenting with Acquired Immune Deficiency Syndrome (AIDS) are predisposed to co-infection with Mycobacterium avium. The management of such patients is problematic due to underlying immuno-incompetence and the high resistance of M. avium to most non-toxic compounds. Therefore, the need for effective agents is obvious. Because phenothiazines, especially the relatively mild thioridazine, have significant activity against Mycobacterium tuberculosis, we investigated the in vitro activity of chlorpromazine, thioridazine, promazine, promethazine and desipramine against a reference and clinical strains of M. avium. The results obtained show that whereas all of the phenothiazines employed in this study had an minimum inhibitory concentration (MIC) against the strains studied that ranged from ca. 10 to >50 mg/L, as was previously shown for M. tuberculosis, thioridazine was the most active of the group against M. avium.
AB - Patients presenting with Acquired Immune Deficiency Syndrome (AIDS) are predisposed to co-infection with Mycobacterium avium. The management of such patients is problematic due to underlying immuno-incompetence and the high resistance of M. avium to most non-toxic compounds. Therefore, the need for effective agents is obvious. Because phenothiazines, especially the relatively mild thioridazine, have significant activity against Mycobacterium tuberculosis, we investigated the in vitro activity of chlorpromazine, thioridazine, promazine, promethazine and desipramine against a reference and clinical strains of M. avium. The results obtained show that whereas all of the phenothiazines employed in this study had an minimum inhibitory concentration (MIC) against the strains studied that ranged from ca. 10 to >50 mg/L, as was previously shown for M. tuberculosis, thioridazine was the most active of the group against M. avium.
KW - AIDS
KW - Antimycobacterial activities in vitro
KW - Mycobacterium avium
KW - Phenothiazines
KW - Thioridazine
UR - http://www.scopus.com/inward/record.url?scp=21344462866&partnerID=8YFLogxK
UR - http://iv.iiarjournals.org/content/19/4/733.long
M3 - Article
C2 - 15999542
AN - SCOPUS:21344462866
SN - 0258-851X
VL - Vol. 19
SP - 733
EP - 736
JO - In Vivo
JF - In Vivo
IS - n.º 4
ER -