The impact of HIV-1 within-host evolution on transmission dynamics

Kristof Theys, Pieter Libin, Andrea Clemencia Pineda-Peña, Ann Nowé, Anne Mieke Vandamme, Ana B. Abecasis

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)

Abstract

The adaptive potential of HIV-1 is a vital mechanism to evade host immune responses and antiviral treatment. However, high evolutionary rates during persistent infection can impair transmission efficiency and alter disease progression in the new host, resulting in a delicate trade-off between within-host virulence and between-host infectiousness. This trade-off is visible in the disparity in evolutionary rates at within-host and between-host levels, and preferential transmission of ancestral donor viruses. Understanding the impact of within-host evolution for epidemiological studies is essential for the design of preventive and therapeutic measures. Herein, we review recent theoretical and experimental work that generated new insights into the complex link between within-host evolution and between-host fitness, revealing temporal and selective processes underlying the structure and dynamics of HIV-1 transmission.

Original languageEnglish
Pages (from-to)92-101
Number of pages10
JournalCurrent Opinion in Virology
Volume28
DOIs
Publication statusPublished - 1 Feb 2018

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