Human chromosomal fragile sites (CFSs) are heritable loci or regions of the human chromosomes prone to exhibit gaps, breaks and rearrangements. Determining the frequency of deletions and duplications in CFSs may contribute to explain the occurrence of human disease due to those rearrangements. In this study we analyzed the frequency of deletions and duplications in each human CFS. Statistical methods, namely data display, descriptive statistics and linear regression analysis were applied to analyze this dataset. We found that FRA15C, FRA16A and FRAXB are the most frequently involved CFSs in deletions and duplications occurring in the human genome.
|Title of host publication||International Conference of Computational Methods in Sciences and Engineering 2016, ICCMSE 2016|
|Publisher||American Institute of Physics|
|Publication status||Published - 6 Dec 2016|
|Event||International Conference of Computational Methods in Sciences and Engineering 2016, ICCMSE 2016 - Athens, Greece|
Duration: 17 Mar 2016 → 20 Mar 2016
|Conference||International Conference of Computational Methods in Sciences and Engineering 2016, ICCMSE 2016|
|Period||17/03/16 → 20/03/16|