A variante genética c825t da subunidade β3 da proteína G associa‐se com a hipertensão arterial numa população portuguesa

Translated title of the contribution: The genetic variant C825T of the beta 3 subunit of G protein is associated with hypertension in a Portuguese population

Ana Célia Sousa, Roberto Palma dos Reis, Andreia Pereira, Sofia Borges, Sara Gouveia, Adelaide Spínola, Ana Isabel Freitas, Graça Guerra, Teresa Góis, Mariana Rodrigues, Eva Henriques, Ilídio Ornelas, Carolina Freitas, Décio Pereira, António Brehm, Maria Isabel Mendonça

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction: Hypertension is an important public health problem, affecting about 25% of the adult population worldwide.1 Genetic and environmental factors contribute to its pathogenesis. The T allele of the C825T polymorphism of the beta 3 subunit of G protein (rs5443) leads to the production of a truncated variant that enhances intracellular signaling and may interfere with the regulation of blood pressure. This genetic variant has been described as a risk factor for hypertension, although study results are controversial. Objective: The objective of this study was to analyze the association of the C825T polymorphism of the GNB3 gene with the occurrence of hypertension in a Portuguese population from the Madeira archipelago. Methods: A case‐control study was performed with 1641 Caucasian individuals (mean age 50.6±8.1 years), 848 with hypertension and 793 controls. Blood was collected from all participants for biochemical and genetic analysis, including genotyping of the C825T polymorphism. Logistic regression analysis was performed to determine which variables were significantly associated with the onset of hypertension. Statistical analyses were performed using IBM SPSS version 19.0 and p‐values <0.05 were considered statistically significant. Results: In our study, there was a significant association between the C825T polymorphism of the GNB3 gene and the occurrence of hypertension (odds ratio 1.275; 95% confidence interval 1.042‐1.559; p=0.018) in the dominant model, after multivariate analysis. Conclusion: We conclude that the C825T polymorphism of the beta 3 subunit of G protein is significantly and independently associated with the occurrence of hypertension in the study population.

Original languagePortuguese
Pages (from-to)499-507
Number of pages8
JournalRevista Portuguesa de Cardiologia
Volume37
Issue number6
DOIs
Publication statusPublished - Jun 2018

Keywords

  • Case‐control study
  • G protein
  • GNB3
  • Hypertension
  • Polymorphisms

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