Perfil epidemiológico dos isolamentos dos microrganismos ‘Problema’

Translated title of the contribution: The epidemiological profile of the Isolation of 'Problem' microorganisms

Pedro Atilano Carvalho, Ana Monteiro, Bruno Almeida, Filomena Horta Correia, Vera Resende, Carla Nunes, Sílvia Lopes

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: Infections are a major problem and the presence of drug-resistant microorganisms has significant clinical and economic impact. The present study aims to evaluate the epidemiological profile of "problem" microorganisms isolated in a hospital in the north of Portugal. MATERIAL AND METHODS: All isolated microorganisms were analyzed, between January 2014 and June 2015. Data obtained was then processed using statistical software. RESULTS: We analyzed 8146 microbiological isolations and found a prevalence of 23% of 'problem' microorganisms (in descending order of frequency: Enterococcus, Pseudomonas, Staphylococcus aureus e Streptococcus pneumonia), 57.55% of which isolated in male patients. The most frequent mechanism of drug resistance for the overall sample was the production of extended-spectrum beta-lactamase, and resistance to oxacillin for 'problem' microorganisms. DISCUSSION: In this sample, we observed a much higher prevalence of 'problem' microorganisms than that reported in other countries, which shows the need of improvement of surveillance mechanisms and treatment of these cases. Microorganisms that showed higher resistance were Staphylococcus aureus (resistant to oxacillin) and Enterococcus (resistant to vancomycin). Those were isolated in patients with a higher mean age compared to non-resistant microorganisms. Most of these microorganisms were isolated in hospitalized patients or intermediate and intensive care units, what relates them with healthcare associated infections. CONCLUSION: The prevalence of infection by 'problem' microorganisms during the studied period was 23%. The detection and control of the spread of these microorganisms are paramount due to its impact on health costs, morbidity and survival of patients.

Original languagePortuguese
Pages (from-to)600-605
Number of pages6
JournalActa medica portuguesa
Volume32
Issue number9
DOIs
Publication statusPublished - 2 Sep 2019

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Oxacillin
Staphylococcus aureus
Portugal
Enterococcus
beta-Lactamases
Cross Infection
Streptococcus pneumoniae
Pseudomonas
Infection
Drug Resistance
Health Care Costs
Intensive Care Units
Software
Economics
Morbidity
Survival
Pharmaceutical Preparations
Therapeutics
Vancomycin-Resistant Enterococci

Keywords

  • Drug Resistance, Microbial
  • Infection/epidemiology
  • Portugal

Cite this

Atilano Carvalho, P., Monteiro, A., Almeida, B., Correia, F. H., Resende, V., Nunes, C., & Lopes, S. (2019). Perfil epidemiológico dos isolamentos dos microrganismos ‘Problema’. Acta medica portuguesa, 32(9), 600-605. https://doi.org/10.20344/amp.10838
Atilano Carvalho, Pedro ; Monteiro, Ana ; Almeida, Bruno ; Correia, Filomena Horta ; Resende, Vera ; Nunes, Carla ; Lopes, Sílvia. / Perfil epidemiológico dos isolamentos dos microrganismos ‘Problema’. In: Acta medica portuguesa. 2019 ; Vol. 32, No. 9. pp. 600-605.
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Atilano Carvalho, P, Monteiro, A, Almeida, B, Correia, FH, Resende, V, Nunes, C & Lopes, S 2019, 'Perfil epidemiológico dos isolamentos dos microrganismos ‘Problema’', Acta medica portuguesa, vol. 32, no. 9, pp. 600-605. https://doi.org/10.20344/amp.10838

Perfil epidemiológico dos isolamentos dos microrganismos ‘Problema’. / Atilano Carvalho, Pedro; Monteiro, Ana; Almeida, Bruno; Correia, Filomena Horta; Resende, Vera; Nunes, Carla; Lopes, Sílvia.

In: Acta medica portuguesa, Vol. 32, No. 9, 02.09.2019, p. 600-605.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Perfil epidemiológico dos isolamentos dos microrganismos ‘Problema’

AU - Atilano Carvalho, Pedro

AU - Monteiro, Ana

AU - Almeida, Bruno

AU - Correia, Filomena Horta

AU - Resende, Vera

AU - Nunes, Carla

AU - Lopes, Sílvia

PY - 2019/9/2

Y1 - 2019/9/2

N2 - INTRODUCTION: Infections are a major problem and the presence of drug-resistant microorganisms has significant clinical and economic impact. The present study aims to evaluate the epidemiological profile of "problem" microorganisms isolated in a hospital in the north of Portugal. MATERIAL AND METHODS: All isolated microorganisms were analyzed, between January 2014 and June 2015. Data obtained was then processed using statistical software. RESULTS: We analyzed 8146 microbiological isolations and found a prevalence of 23% of 'problem' microorganisms (in descending order of frequency: Enterococcus, Pseudomonas, Staphylococcus aureus e Streptococcus pneumonia), 57.55% of which isolated in male patients. The most frequent mechanism of drug resistance for the overall sample was the production of extended-spectrum beta-lactamase, and resistance to oxacillin for 'problem' microorganisms. DISCUSSION: In this sample, we observed a much higher prevalence of 'problem' microorganisms than that reported in other countries, which shows the need of improvement of surveillance mechanisms and treatment of these cases. Microorganisms that showed higher resistance were Staphylococcus aureus (resistant to oxacillin) and Enterococcus (resistant to vancomycin). Those were isolated in patients with a higher mean age compared to non-resistant microorganisms. Most of these microorganisms were isolated in hospitalized patients or intermediate and intensive care units, what relates them with healthcare associated infections. CONCLUSION: The prevalence of infection by 'problem' microorganisms during the studied period was 23%. The detection and control of the spread of these microorganisms are paramount due to its impact on health costs, morbidity and survival of patients.

AB - INTRODUCTION: Infections are a major problem and the presence of drug-resistant microorganisms has significant clinical and economic impact. The present study aims to evaluate the epidemiological profile of "problem" microorganisms isolated in a hospital in the north of Portugal. MATERIAL AND METHODS: All isolated microorganisms were analyzed, between January 2014 and June 2015. Data obtained was then processed using statistical software. RESULTS: We analyzed 8146 microbiological isolations and found a prevalence of 23% of 'problem' microorganisms (in descending order of frequency: Enterococcus, Pseudomonas, Staphylococcus aureus e Streptococcus pneumonia), 57.55% of which isolated in male patients. The most frequent mechanism of drug resistance for the overall sample was the production of extended-spectrum beta-lactamase, and resistance to oxacillin for 'problem' microorganisms. DISCUSSION: In this sample, we observed a much higher prevalence of 'problem' microorganisms than that reported in other countries, which shows the need of improvement of surveillance mechanisms and treatment of these cases. Microorganisms that showed higher resistance were Staphylococcus aureus (resistant to oxacillin) and Enterococcus (resistant to vancomycin). Those were isolated in patients with a higher mean age compared to non-resistant microorganisms. Most of these microorganisms were isolated in hospitalized patients or intermediate and intensive care units, what relates them with healthcare associated infections. CONCLUSION: The prevalence of infection by 'problem' microorganisms during the studied period was 23%. The detection and control of the spread of these microorganisms are paramount due to its impact on health costs, morbidity and survival of patients.

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KW - Infection/epidemiology

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Atilano Carvalho P, Monteiro A, Almeida B, Correia FH, Resende V, Nunes C et al. Perfil epidemiológico dos isolamentos dos microrganismos ‘Problema’. Acta medica portuguesa. 2019 Sep 2;32(9):600-605. https://doi.org/10.20344/amp.10838